scholarly journals Loureirin B activates GLP‐1R and promotes insulin secretion in Ins‐1 cells

2020 ◽  
Author(s):  
Yanting Ding ◽  
Sijing Xia ◽  
Han Zhang ◽  
Qin Chen ◽  
Bing Niu
Keyword(s):  
Insulin Secretion ◽  
Loureirin B

scholarly journals Insulin Secretion with the Effect of Loureirin B through KATP Channel–Dependent Pathway

2017 ◽  
Author(s):  
Yijie Sha ◽  
Yuelin Zhang ◽  
Jing Cao ◽  
Kai Qian ◽  
Bing Niu ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Computational Methods ◽  
Katp Channels ◽  
Glucose Levels ◽  
Significant Difference ◽  
Voltage Dependent ◽  
Decrease Blood Glucose ◽  
Voltage Dependent Calcium Channels ◽  
Increase Insulin Secretion ◽  
Loureirin B

The development of new diabetes drugs continues to be explored. Loureirin B, a flavonoid, extracted from Dracaena cochinchinensis, has been confirmed to increase insulin secretion and decrease blood glucose levels. For understanding the mechanism, a series of experiments had been employed based on computational methods and cell experiments. The insulin secretion significantly increased with the incubation of 0.01μM loureirin B for 4 hours. The viability of Ins-1 cells showed no significant difference with the treatment of loureirin B. Through computational methods, we hypothesized that loureirin B could interacts with KATP channels to promote insulin secretion. In cell experiments, it could be found that the current of KATP channel of Ins-1 cells was inhibited by the effect of loureirin B. After then, the voltage-dependent calcium channels were activated, the increase of Cx43 protein expression might mediate the Ca2+ to the intracellular. In summary, it could be concluded that loureirin B promoted insulin secretion mainly through inhibiting KATP current, the influx of Ca2+ to the Intracellular and the expression of Cx43.

Loureirin B promotes insulin secretion through inhibition of K ATP channel and influx of intracellular calcium

2017 ◽  
Vol 119 (2) ◽  
pp. 2012-2021 ◽  
Author(s):  
Yijie Sha ◽  
Yuelin Zhang ◽  
Jing Cao ◽  
Kai Qian ◽  
Bing Niu ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Intracellular Calcium ◽  
Loureirin B

Intraisiet somatostatin inhibits insulin secretion via SSTR5 in the isolated perfused mouse pancreas model

2001 ◽  
Vol 120 (5) ◽  
pp. A133-A133
Author(s):  
T TIRONE ◽  
S MOLDOVAN ◽  
M NORMAL ◽  
F DEMAYO ◽  
F CHARLESBRUNICARDI
Keyword(s):  
Insulin Secretion ◽  
Mouse Pancreas
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