scholarly journals PDE1 or PDE5 inhibition augments NO‐dependent hypoxic constriction of porcine coronary artery via elevating inosine 3′,5′‐cyclic monophosphate level

2020 ◽  
Vol 24 (24) ◽  
pp. 14514-14524
Author(s):  
Yan Nan ◽  
Xueqin Zeng ◽  
Zhiyi Jin ◽  
Na Li ◽  
Zhengju Chen ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Porcine Coronary Artery ◽  
Cyclic Monophosphate ◽  
Pde5 Inhibition

Two mechanisms mediate relaxation by bradykinin of pig coronary artery: NO-dependent and -independent responses

1991 ◽  
Vol 261 (3) ◽  
pp. H830-H835 ◽  
Author(s):  
C. L. Cowan ◽  
R. A. Cohen
Keyword(s):  
Nitric Oxide ◽  
Methylene Blue ◽  
Coronary Artery ◽  
Thromboxane A2 ◽  
Porcine Coronary Artery ◽  
Cyclic Monophosphate ◽  
Pig Coronary Artery ◽  
Endothelium Dependent Relaxation

The role of nitric oxide and guanosine 3',5'-cyclic monophosphate (cGMP) accumulation in the endothelium-dependent relaxation of the porcine coronary artery to bradykinin was investigated by comparing relaxation and cGMP accumulation in the presence or absence of NG-monomethyl-L-arginine (L-NMMA) and methylene blue. Rings were treated with indomethacin to eliminate the effects of prostaglandins. Relaxation to bradykinin of rings contracted with the thromboxane A2 mimetic U-46619 was not affected by L-NMMA and was only minimally inhibited by methylene blue. Rings contracted with elevated potassium (25 mM) also relaxed completely to bradykinin. However, L-NMMA or methylene blue effectively inhibited relaxation to bradykinin in rings contracted with potassium. cGMP accumulation was stimulated by bradykinin and inhibited by L-NMMA or methylene blue in rings contracted with either U-46619 or potassium. These results suggest that in the absence of nitric oxide-induced cGMP accumulation, a nonprostanoid mechanism exists that is capable of completely relaxing U-46619-contracted coronary artery. This mechanism is either inhibited in or unable to relax potassium-contracted rings. These results also demonstrate that nitric oxide mediates the bradykinin-induced cGMP accumulation that is largely responsible for the relaxation during contraction with potassium.

Role of nitric oxide in adenosine receptor-mediated relaxation of porcine coronary artery

1995 ◽  
Vol 269 (5) ◽  
pp. H1672-H1678 ◽  
Author(s):  
W. Abebe ◽  
T. Hussain ◽  
H. Olanrewaju ◽  
S. J. Mustafa
Keyword(s):  
Nitric Oxide ◽  
Coronary Artery ◽  
Porcine Coronary Artery ◽  
Cyclic Monophosphate ◽  
Enhanced Production ◽  
Cgs 21680 ◽  
Synthase Inhibitor ◽  
Ly 83583

In the present study, using porcine coronary artery rings in vitro, we examined the role of the nitric oxide (NO) pathway in endothelium-dependent vasorelaxant effects of the 5'-uronamide adenosine agonists, 5'-(N-ethylcarboxamido)adenosine (NECA) and 2-[p-(2-carboxyethyl)]phenylethyl-amino-5'-N-ethylcarboxamidoadenosine (CGS-21680) as opposed to the endothelium-independent actions of the C2- and N6-substituted analogues, 2-chloroadenosine (CAD) and N6-cyclopentyladenosine (CPA). The NO synthase inhibitor, NG-monomethyl-L-arginine (L-NMMA, 30 microM), and the NO-destroying agent, 6-anilino-5,8-quinolinedione (LY-83583, 10 microM), attenuated the relaxations of endothelium-intact but not -denuded rings to NECA and CGS-21680. The effect of L-NMMA on NECA-induced relaxation was reversed by L-arginine (100 microM), a substrate for NO synthesis. In the endothelium-intact tissues, both NECA and CGS-21680 elicited enhanced production of nitrite, a stable metabolite of NO. This was also attenuated by L-NMMA or endothelium removal. Furthermore, NECA (10 microM) induced augmentation of guanosine 3',5'-cyclic monophosphate (cGMP) production in the intact arteries, which was also inhibited by L-NMMA, LY-83583, or endothelium removal. In contrast, vasorelaxant responses generated by CAD and CPA were not altered by either L-NMMA or LY-83583. Both agents (10 microM) were also unable to alter nitrite and/or guanosine 3',5'-cyclic monophosphate (cGMP) levels of the coronary artery.(ABSTRACT TRUNCATED AT 250 WORDS)

Characterization of Thromboxane A2/Prostaglandin H2 Receptors in Porcine Coronary Artery -The Inhibitory Effect of a Novel Dibenzoxepin Derivative, KW-3635

1992 ◽  
Vol 67 (05) ◽  
pp. 582-584 ◽  
Author(s):  
Ichiro Miki ◽  
Akio Ishii
Keyword(s):  
Coronary Artery ◽  
Binding Sites ◽  
Thromboxane A2 ◽  
Inhibitory Effect ◽  
Scatchard Analysis ◽  
Single Class ◽  
Porcine Coronary Artery ◽  
Equilibrium Binding ◽  
H2 Receptors

SummaryWe characterized the thromboxane A2/prostaglandin H2 receptors in porcine coronary artery. The binding of [3H]SQ 29,548, a thromboxane A2 antagonist, to coronary arterial membranes was saturable and displaceable. Scatchard analysis of equilibrium binding showed a single class of high affinity binding sites with a dissociation constant of 18.5 ±1.0 nM and the maximum binding of 80.7 ± 5.2 fmol/mg protein. [3H]SQ 29,548 binding was concentration-dependently inhibited by thromboxane A2 antagonists such as SQ 29,548, BM13505 and BM13177 or the thromboxane A2 agonists such as U46619 and U44069. KW-3635, a novel dibenzoxepin derivative, concentration-dependently inhibited the [3H]SQ 29,548 binding to thromboxane A2/prosta-glandin H2 receptors in coronary artery with an inhibition constant of 6.0 ± 0.69 nM (mean ± S.E.M.).

Effect of Local Paclitaxel Delivery Following Stenting on Restenosis and Morphology in the Porcine Coronary Artery

2008 ◽  
Vol 2 (1) ◽  
pp. 299-303
Author(s):  
Martin Oberhoff ◽  
Matthias Lerch ◽  
Christian Herdeg ◽  
Axel Kuttner ◽  
Stephen Schroder ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Porcine Coronary Artery

Nicorandil Stimulates Release Of Adenyl Purines From Porcine Coronary Artery

2000 ◽  
Vol 27 (9) ◽  
pp. 680-683
Author(s):  
Tetsuya Sasaki ◽  
Michio Hashimoto ◽  
Seishi Nosaka ◽  
Tomoki Hanada ◽  
Yuhei Saitoh ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Porcine Coronary Artery

scholarly journals COMPARISONS OF SAFETY PROFILE BETWEEN DURABLE AND BIODEGRADABLE POLYMER BASED DRUG ELUTING STENTS IN PORCINE CORONARY ARTERY MODEL

2012 ◽  
Vol 59 (13) ◽  
pp. E315
Author(s):  
Takeshi Ijichi ◽  
Gaku Nakazawa ◽  
Toshiro Shinke ◽  
Daisuke Matsumoto ◽  
Hiromasa Otake ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Biodegradable Polymer ◽  
Safety Profile ◽  
Drug Eluting Stents ◽  
Porcine Coronary Artery ◽  
Drug Eluting
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