scholarly journals 20( S )‐Protopanaxadiol inhibits epithelial‐mesenchymal transition by promoting retinoid X receptor alpha in human colorectal carcinoma cells

2020 ◽  
Vol 24 (24) ◽  
pp. 14349-14365
Author(s):  
Zeyuan Lu ◽  
Hongyan Liu ◽  
Wenwen Fu ◽  
Yuchen Wang ◽  
Jianan Geng ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Epithelial Mesenchymal Transition ◽  
Retinoid X Receptor ◽  
Carcinoma Cells ◽  
Mesenchymal Transition ◽  
Receptor Alpha ◽  
Human Colorectal Carcinoma ◽  
Retinoid X Receptor Alpha

scholarly journals Pien Tze Huang Overcomes Multidrug Resistance and Epithelial-Mesenchymal Transition in Human Colorectal Carcinoma Cells via Suppression of TGF-βPathway

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Aling Shen ◽  
Hongwei Chen ◽  
Youqin Chen ◽  
Jiumao Lin ◽  
Wei Lin ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Colorectal Carcinoma ◽  
Epithelial Mesenchymal Transition ◽  
Carcinoma Cells ◽  
Migration And Invasion ◽  
Dependent Manner ◽  
Mesenchymal Transition ◽  
Folk Remedy ◽  
Pien Tze Huang ◽  
Human Colorectal Carcinoma

The traditional Chinese medicine formula Pien Tze Huang (PZH) has long been used as a folk remedy for cancer. To elucidate the mode of action of PZH against cancer, in the present study we used a 5-FU resistant human colorectal carcinoma cell line (HCT-8/5-FU) to evaluate the effects of PZH on multidrug resistance (MDR) and epithelial-mesenchymal transition (EMT) as well as the activation of TGF-βpathway. We found that PZH dose-dependently inhibited the viability of HCT-8/5-FU cells which were insensitive to treatment of 5-FU and ADM, demonstrating the ability of PZH to overcome chemoresistance. Furthermore, PZH increased the intercellular accumulation of Rhodamine-123 and downregulated the expression of ABCG2 in HCT-8/5-FU cells. In addition, drug resistance induced the process of EMT in HCT-8 cells as evidenced by EMT-related morphological changes and alteration in the expression of EMT-regulatory factors, which however was neutralized by PZH treatment. Moreover, PZH inhibited MDR/EMT-enhanced migration and invasion capabilities of HCT-8 cells in a dose-dependent manner and suppressed MDR-induced activation of TGF-βsignaling in HCT-8/5-FU cells. Taken together, our study suggests that PZH can effectively overcome MDR and inhibit EMT in human colorectal carcinoma cells via suppression of the TGF-βpathway.

scholarly journals Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (61) ◽  
pp. 103900-103918 ◽  
Author(s):  
Jing-Jing Wang ◽  
Qing-Yun Chong ◽  
Xin-Bao Sun ◽  
Ming-Liang You ◽  
Vijay Pandey ◽  
...  
Keyword(s):  
Stem Cell ◽  
Colorectal Carcinoma ◽  
Cancer Stem Cell ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Human Colorectal Carcinoma

scholarly journals TNF-α Induces Epithelial–Mesenchymal Transition of Renal Cell Carcinoma Cells via a GSK3β-Dependent Mechanism

2012 ◽  
Vol 10 (8) ◽  
pp. 1109-1119 ◽  
Author(s):  
Ming-Yi Ho ◽  
Shye-Jye Tang ◽  
Mei-Jen Chuang ◽  
Tai-Lung Cha ◽  
Jing-Yao Li ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Epithelial Mesenchymal Transition ◽  
Carcinoma Cells ◽  
Mesenchymal Transition ◽  
Tnf Α ◽  
Dependent Mechanism
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