scholarly journals Hypoxic bone marrow mesenchymal cell‐extracellular vesicles containing miR‐328‐3p promote lung cancer progression via the NF2‐mediated Hippo axis

2020 ◽  
Author(s):  
Xi Liu ◽  
Feng Jiang ◽  
Zhilinag Wang ◽  
Lang Tang ◽  
Bin Zou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Bone Marrow ◽  
Extracellular Vesicles ◽  
Cancer Progression ◽  
Mesenchymal Cell ◽  
Bone Marrow Mesenchymal Cell

scholarly journals Microenvironmental Hypoxia Induces Dynamic Changes in Lung Cancer Synthesis and Secretion of Extracellular Vesicles

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2917
Author(s):  
Shun Wilford Tse ◽  
Chee Fan Tan ◽  
Jung Eun Park ◽  
JebaMercy Gnanasekaran ◽  
Nikhil Gupta ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Extracellular Vesicles ◽  
Cancer Progression ◽  
Membrane Trafficking ◽  
Epithelial Mesenchymal Transition ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Functional Clustering ◽  
Signalling Molecules ◽  
Proteomic Approach

Extracellular vesicles (EVs) mediate critical intercellular communication within healthy tissues, but are also exploited by tumour cells to promote angiogenesis, metastasis, and host immunosuppression under hypoxic stress. We hypothesize that hypoxic tumours synthesize hypoxia-sensitive proteins for packing into EVs to modulate their microenvironment for cancer progression. In the current report, we employed a heavy isotope pulse/trace quantitative proteomic approach to study hypoxia sensitive proteins in tumour-derived EVs protein. The results revealed that hypoxia stimulated cells to synthesize EVs proteins involved in enhancing tumour cell proliferation (NRSN2, WISP2, SPRX1, LCK), metastasis (GOLM1, STC1, MGAT5B), stemness (STC1, TMEM59), angiogenesis (ANGPTL4), and suppressing host immunity (CD70). In addition, functional clustering analyses revealed that tumour hypoxia was strongly associated with rapid synthesis and EV loading of lysosome-related hydrolases and membrane-trafficking proteins to enhance EVs secretion. Moreover, lung cancer-derived EVs were also enriched in signalling molecules capable of inducing epithelial-mesenchymal transition in recipient cancer cells to promote their migration and invasion. Together, these data indicate that lung-cancer-derived EVs can act as paracrine/autocrine mediators of tumorigenesis and metastasis in hypoxic microenvironments. Tumour EVs may, therefore, offer novel opportunities for useful biomarkers discovery and therapeutic targeting of different cancer types and at different stages according to microenvironmental conditions.

scholarly journals Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate

2017 ◽  
Vol 25 (3) ◽  
pp. 661-672 ◽  
Author(s):  
Yi Fan ◽  
Jun-ichi Hanai ◽  
Phuong T. Le ◽  
Ruiye Bi ◽  
David Maridas ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Parathyroid Hormone ◽  
Cell Fate ◽  
Mesenchymal Cell ◽  
Bone Marrow Mesenchymal Cell

scholarly journals Depletion of Cytosolic Phospholipase A2 in Bone Marrow–Derived Macrophages Protects against Lung Cancer Progression and Metastasis

2009 ◽  
Vol 69 (5) ◽  
pp. 1733-1738 ◽  
Author(s):  
Mary C.M. Weiser-Evans ◽  
Xue-Qing Wang ◽  
Jay Amin ◽  
Vicki Van Putten ◽  
Rashmi Choudhary ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Bone Marrow ◽  
Phospholipase A2 ◽  
Cancer Progression ◽  
Cytosolic Phospholipase A2 ◽  
Cytosolic Phospholipase
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