scholarly journals The neurofibromatosis type I gene promotes autophagy via mTORC1 signalling pathway to enhance new bone formation after fracture

2020 ◽  
Vol 24 (19) ◽  
pp. 11524-11534
Author(s):  
Qian Tan ◽  
Jiang‐Yan Wu ◽  
Yao‐Xi Liu ◽  
Kun Liu ◽  
Jin Tang ◽  
...  
Keyword(s):  
Bone Formation ◽  
Neurofibromatosis Type ◽  
Signalling Pathway ◽  
Type I ◽  
Neurofibromatosis Type I ◽  
New Bone Formation ◽  
I Gene

Neurofibromatosis type I gene mutation in a patient with features of LEOPARD syndrome

1996 ◽  
Vol 8 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Rina Wu ◽  
Eric Legius ◽  
Wim Robberecht ◽  
Monique Dumoulin ◽  
Jean-Jacques Cassiman ◽  
...  
Keyword(s):  
Gene Mutation ◽  
Neurofibromatosis Type ◽  
Type I ◽  
Neurofibromatosis Type I ◽  
Leopard Syndrome ◽  
I Gene

mTORC1 signaling is essential for neurofibromatosis type I gene modulated osteogenic differentiation of BMSCs

2018 ◽  
Vol 120 (3) ◽  
pp. 2886-2896 ◽  
Author(s):  
YiQiang Li ◽  
JingChun Li ◽  
QingHe Zhou ◽  
Yuanzhong Liu ◽  
WeiDong Chen ◽  
...  
Keyword(s):  
Osteogenic Differentiation ◽  
Neurofibromatosis Type ◽  
Type I ◽  
Neurofibromatosis Type I ◽  
Mtorc1 Signaling ◽  
I Gene

Can 18FDG-PET detect malignant transformation of neurofibromas in patients with neurofibromatosis type I?

2006 ◽  
Vol 37 (06) ◽  
Author(s):  
J Neinert ◽  
E Fastnacht ◽  
R Larisch ◽  
E Legius ◽  
R Engelskirchen ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Neurofibromatosis Type ◽  
Type I ◽  
Neurofibromatosis Type I ◽  
18Fdg Pet

Tissue Engineering of Bone by Osteoinductive Biomaterials

MRS Bulletin ◽  
1996 ◽  
Vol 21 (11) ◽  
pp. 36-39 ◽  
Author(s):  
Ugo Ripamonti ◽  
Nicolaas Duneas
Keyword(s):  
Tissue Engineering ◽  
Bone Formation ◽  
Type I Collagen ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Mesenchymal Cells ◽  
Tissue Response ◽  
Type I ◽  
New Bone Formation ◽  
Demineralized Bone

Recent advances in materials science and biotechnology have given birth to the new and exciting field of tissue engineering, in which the two normally disparate fields are merging into a profitable matrimony. In particular the use of biomaterials capable of initiating new bone formation via a process called osteoinduction is leading to quantum leaps for the tissue engineering of bone.The classic work of Marshall R. Urist and A. Hari Reddi opened the field of osteoinductive biomaterials. Urist discovered that, upon implantation of devitalized, demineralized bone matrix in the muscle of experimental animals, new bone formation occurs within two weeks, a phenomenon he described as bone formation by induction. The tissue response elicited by implantation of demineralized bone matrix in muscle or under the skin includes activation and migration of undifferentiated mesenchymal cells by chemotaxis, anchoragedependent cell attachment to the matrix, mitosis and proliferation of mesenchymal cells, differentiation of cartilage, mineralization of the cartilage, vascular invasion of the cartilage, differentiation of osteoblasts and deposition of bone matrix, and finally mineralization of bone and differentiation of marrow in the newly developed ossicle.The osteoinductive ability of the extracellular matrix of bone is abolished by the dissociative extraction of the demineralized matrix, but is recovered when the extracted component, itself inactive, is reconstituted with the inactive residue—mainly insoluble collagenous bone matrix. This important experiment showed that the osteoinductive signal resides in the solubilized component but needs to be reconstituted with an appropriate carrier to restore the osteoinductive activity. In this case, the carrier is the insoluble collagenous bone matrix—mainly crosslinked type I collagen.

scholarly journals Folliculosebaceous Cystic Hamartoma in a Patient with Neurofibromatosis Type I

2011 ◽  
Vol 23 (Suppl 2) ◽  
pp. S185 ◽  
Author(s):  
Seongmin Noh ◽  
Ji Eun Kwon ◽  
Kwang Gil Lee ◽  
Mi Ryung Roh
Keyword(s):  
Neurofibromatosis Type ◽  
Type I ◽  
Neurofibromatosis Type I ◽  
Cystic Hamartoma
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