scholarly journals Tumour‐derived exosomal miR‐3473b promotes lung tumour cell intrapulmonary colonization by activating the nuclear factor‐κB of local fibroblasts

2020 ◽  
Vol 24 (14) ◽  
pp. 7802-7813 ◽  
Author(s):  
Cancan Du ◽  
Xixi Duan ◽  
Xiaohan Yao ◽  
Jiajia Wan ◽  
Yanru Cheng ◽  
...  
Keyword(s):  
Tumour Cell ◽  
Nuclear Factor Κb ◽  
Lung Tumour ◽  
Nuclear Factor

scholarly journals Constitutive nuclear factor κB activity is required to elicit interferon-γ-induced expression of chemokine CXC ligand 9 (CXCL9) and CXCL10 in human tumour cell lines

2003 ◽  
Vol 376 (2) ◽  
pp. 393-402 ◽  
Author(s):  
Miki HIROI ◽  
Yoshihiro OHMORI
Keyword(s):  
Cell Lines ◽  
Tumour Cell ◽  
Nuclear Factor Κb ◽  
Interferon Γ ◽  
Nuclear Factor ◽  
Human Tumour ◽  
Induced Expression ◽  
Oral Squamous Carcinoma ◽  
Tumour Cell Lines ◽  
Human Tumour Cell Lines

CXC ligand 10 (CXCL10) and CXCL9 are chemoattractants for activated T cells and possess angiostatic activity. Both CXCL9 and CXCL10 have been considered as important components for the anti-tumour activities of interferon-γ (IFNγ) and interleukin-12 in animal models. In this article we show that the CXCL9 and CXCL10 genes in some types of human tumour cell lines are not inducible by IFNγ and we describe experiments designed to explore the molecular mechanisms involved in this impaired induction. The human oral squamous carcinoma line Ca9-22 and the glioma line A172 failed to express CXCL9 and CXCL10 mRNAs in response to IFNγ, whereas other carcinoma lines including HSC-2 did express these mRNAs. Production of these chemokine proteins was also impaired in Ca9-22 cells. The impaired expression was not due to any deficiency in the IFNγ/signal transducer and activator of transcription 1 (STAT1)-dependent signalling pathway. Instead, analysis of nuclear factor κB (NF-κB) activity revealed that the constitutive low level of NF-κB activity, which is seen in cells that express these chemokines, was absent in Ca9-22 and A172 cells. Activation of NF-κB in Ca9-22 cells restored the expression of IFNγ-stimulated CXCL9 and CXCL10 mRNAs. In contrast, inhibition of the constitutive NF-κB in HSC-2 cells by adenovirus-mediated gene transfer of a dominant-negative IκBα suppressed the IFNγ-induced expression of the CXCL9 and CXCL10 mRNAs. These results indicate that constitutive NF-κB activity, which is often associated with tumour development, is required for the induced expression of CXCL9 and CXCL10 genes in human tumour cell lines in response to IFNγ.

NLRP3 inflammasome expression in cultured hepatocytes is regulated by nuclear factor-κB (NF-κB)

2015 ◽  
Vol 53 (01) ◽  
Author(s):  
SG Boaru ◽  
E Borkham-Kamphorst ◽  
E Van de Leur ◽  
C Liedtke ◽  
R Weiskirchen
Keyword(s):  
Nlrp3 Inflammasome ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Cultured Hepatocytes

Nuclear Factor κB and Adenosine Receptors: Biochemical and Behavioral Profiling

2011 ◽  
Vol 999 (999) ◽  
pp. 1-8 ◽  
Author(s):  
Vickram Ramkumar ◽  
Krishna A. Jhaveri ◽  
Xiaobin Xie ◽  
Sarvesh Jajoo ◽  
Linda A. Toth
Keyword(s):  
Adenosine Receptors ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Behavioral Profiling
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