scholarly journals Peroxisome proliferator‐activated receptor gamma‐ligand‐binding domain mutations associated with familial partial lipodystrophy type 3 disrupt human trophoblast fusion and fibroblast migration

2020 ◽  
Vol 24 (13) ◽  
pp. 7660-7669
Author(s):  
Hussein Shoaito ◽  
Sabine Chauveau ◽  
Camille Gosseaume ◽  
William Bourguet ◽  
Corinne Vigouroux ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Human Trophoblast ◽  
Partial Lipodystrophy ◽  
Fibroblast Migration ◽  
Familial Partial Lipodystrophy ◽  
Type 3

Novel peroxisome proliferator-activated receptor gamma mutation in a family with familial partial lipodystrophy type 3

2015 ◽  
Vol 84 (1) ◽  
pp. 141-148 ◽  
Author(s):  
Konstanze Miehle ◽  
Joseph Porrmann ◽  
Diana Mitter ◽  
Michael Stumvoll ◽  
Christiane Glaser ◽  
...  
Keyword(s):  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Partial Lipodystrophy ◽  
Familial Partial Lipodystrophy ◽  
Type 3

scholarly journals Docking of Phytochemicals to the Peroxisome Proliferator-Activated Receptor-Gamma Ligand Binding Domain

2012 ◽  
Vol 69 (2) ◽  
Author(s):  
Cristina COMAN ◽  
Carmen SOCACIU
Keyword(s):  
Hydrogen Bond ◽  
Ligand Binding ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Peroxisome Proliferator ◽  
Amino Acid Residues ◽  
Theoretical Level ◽  
Hydrogen Atoms ◽  
Peroxisome Proliferator Activated Receptor ◽  
Hydrogen Bond Interactions

In this study, the interaction between the phytochemical molecules - piperine and pipernonaline - and the ligand binding domain of the peroxisome proliferator-activated receptor-γ is investigated at a theoretical level by using the AutoDock software, which is a program that allows docking of molecular ligands to receptor macromolecules. The docking results show that the ligandreceptor complexes are formed through hydrogen bond interactions. The hydrogen bonds involve oxygen atoms in the piperine and pipernonaline ligands as hydrogen bond acceptors and hydrogen atoms from =NH or -NH groups of the amino acid residues in the receptor as hydrogen bond donors.  2

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