scholarly journals Mindin serves as a tumour suppressor gene during colon cancer progression through MAPK/ERK signalling pathway in mice

2020 ◽  
Vol 24 (15) ◽  
pp. 8391-8404
Author(s):  
Xiao‐Shen Cheng ◽  
Ya‐Ni Huo ◽  
Yan‐Yun Fan ◽  
Chuan‐Xing Xiao ◽  
Xiao‐Mei Ouyang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Progression ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Signalling Pathway ◽  
Colon Cancer Progression

scholarly journals Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer

2006 ◽  
Vol 95 (10) ◽  
pp. 1419-1423 ◽  
Author(s):  
C Rimkus ◽  
M Martini ◽  
J Friederichs ◽  
R Rosenberg ◽  
D Doll ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Prognostic Significance ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Candidate Tumour Suppressor

Alterations in tumour suppressor gene p53 correlate with inhibition of thrombospondin-1 gene expression in colon cancer cells

1998 ◽  
Vol 433 (5) ◽  
pp. 415-418 ◽  
Author(s):  
Tetsuji Tokunaga ◽  
M. Nakamura ◽  
Yoshiro Oshika ◽  
Takashi Tsuchida ◽  
Michitake Kazuno ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Colon Cancer Cells ◽  
Thrombospondin 1

Microallelotyping defines the sequence and tempo of alleiic losses at tumour suppressor gene loci during colorectal cancer progression

1995 ◽  
Vol 1 (9) ◽  
pp. 902-909 ◽  
Author(s):  
C. Richard Boland ◽  
Juichi Sato ◽  
Henry D. Appelman ◽  
Robert S. Bresalier ◽  
Andrew P. Feinberg
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Colorectal Cancer Progression

scholarly journals TP53 and C-MYC Co-Alterations – A Hallmark of Oral Cancer Progression / SIMULTANA ALTERACIJA TP53 I C-MYC GENA – OBELEŽJE PROGRESIJE ORALNIH KARCINOMA

2013 ◽  
Vol 32 (4) ◽  
pp. 380-388 ◽  
Author(s):  
Nasta Tanić ◽  
Jelena Milašin ◽  
Tatjana Dramićanin ◽  
Maja Bošković ◽  
Miroslav Vukadinović ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Progression ◽  
Squamous Cell ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Pcr Analysis ◽  
Squamous Cell Carci ◽  
Myc Oncogene ◽  
Specific Pcr

Summary Background: Head and neck squamous cell carcinoma, including oral cancer, is the sixth most common cancer worldwide. Despite advances in surgery and treatment, the 5-year survival rate has not improved significantly. There- fore, reliable molecular markers for oral cancer progression are badly needed. Methods: We conducted a copy number analysis to esti- mate amplification status of c-myc, cycD1 and EGFR onco- genes, mutational PCR-SSCP analysis to determine activa- tion of H-ras oncogene and inactivation of TP55 tumour suppressor gene and methylation specific PCR analysis to evaluate hypermethylation of p16 and MGMT genes. Results: c-myc oncogene was amplified in 56.7%, cycD1 in 20% and EGFR in 16.7% of Oral Squamous Cell Carci- noma (OSCC) cases while H-ras was activated in 33.3% of samples. Amplification of c-myc was significantly associat- ed with the tumour grade 2. Interestingly, EGFR and H-ras alterations were mutually exclusive. p16 and MGMT were inactivated by hypermethylation in 30% and 13.3% of cases. Co-alteration of cycD1 and p16 were not observed in any of the analyzed samples. TP53 was inactivated in 56.7% of samples and was significantly associated with progression of OSCC, grade 2 and stage 2. Moreover, TP55 and c-myc oncogene were simultaneously altered in grade 2 OSCC. Conclusions: The most promising marker of OSCC pro- gression remains the TP53 tumour suppressor, which is the most frequently mutated gene in oral cancers. Since there is synergism between TP55 and c-myc, it seems that co- alteration of these two genes could be also a good marker of OSCC progression from gradel to grade 2 tumours.

104 Loss of speckle-type POZ protein (SPOP) during prostate cancer progression indicates its role as tumour suppressor gene

2014 ◽  
Vol 13 (1) ◽  
pp. e104
Author(s):  
Briones J. Rubio ◽  
I. Casanova-Salas ◽  
M. García-Flores ◽  
A. Calatrava ◽  
J. Casanova ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Prostate Cancer Progression
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