scholarly journals Differential expression of microRNA in serum fractions and association of Argonaute 1 microRNAs with heart failure

2020 ◽  
Vol 24 (12) ◽  
pp. 6586-6595
Author(s):  
Eti Meiri ◽  
Natalia Volinsky ◽  
Nir Dromi ◽  
Sharon Kredo‐Russo ◽  
Hila Benjamin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Differential Expression ◽  
Serum Fractions ◽  
Argonaute 1

scholarly journals P301Inflammatory signaling is activated in association with differential expression of lncRNAs in heart failure with preserved systolic function

2018 ◽  
Vol 114 (suppl_1) ◽  
pp. S77-S77
Author(s):  
K Iwai ◽  
K Watanabe ◽  
Y Igarashi ◽  
T Morita ◽  
H Yano ◽  
...  
Keyword(s):  
Heart Failure ◽  
Differential Expression ◽  
Systolic Function

scholarly journals Role of microRNA in metabolic shift during heart failure

2017 ◽  
Vol 312 (1) ◽  
pp. H33-H45 ◽  
Author(s):  
Mark V. Pinti ◽  
Quincy A. Hathaway ◽  
John M. Hollander
Keyword(s):  
Heart Failure ◽  
Energy Metabolism ◽  
Differential Expression ◽  
Survival Rates ◽  
Disease States ◽  
Posttranscriptional Gene Regulation ◽  
Transport Chain ◽  
Mirna Species ◽  
Pathological Environment

Heart failure (HF) is an end point resulting from a number of disease states. The prognosis for HF patients is poor with survival rates precipitously low. Energy metabolism is centrally linked to the development of HF, and it involves the proteomic remodeling of numerous pathways, many of which are targeted to the mitochondrion. microRNAs (miRNA) are noncoding RNAs that influence posttranscriptional gene regulation. miRNA have garnered considerable attention for their ability to orchestrate changes to the transcriptome, and ultimately the proteome, during HF. Recently, interest in the role played by miRNA in the regulation of energy metabolism at the mitochondrion has emerged. Cardiac proteome remodeling during HF includes axes impacting hypertrophy, oxidative stress, calcium homeostasis, and metabolic fuel transition. Although it is established that the pathological environment of hypoxia and hemodynamic stress significantly contribute to the HF phenotype, it remains unclear as to the mechanistic underpinnings driving proteome remodeling. The aim of this review is to present evidence highlighting the role played by miRNA in these processes as a means for linking pathological stimuli with proteomic alteration. The differential expression of proteins of substrate transport, glycolysis, β-oxidation, ketone metabolism, the citric acid cycle (CAC), and the electron transport chain (ETC) are paralleled by the differential expression of miRNA species that modulate these processes. Identification of miRNAs that translocate to cardiomyocyte mitochondria (miR-181c, miR-378) influencing the expression of the mitochondrial genome-encoded transcripts as well as suggested import modulators are discussed. Current insights, applications, and challenges of miRNA-based therapeutics are also described.

Differential expression of tumoral necrosis factor α and interleukin 6 in patients with severe heart failure

2004 ◽  
Vol 10 (4) ◽  
pp. S53
Author(s):  
Ricardo M. Rocha ◽  
Denilson C. Albuquerque ◽  
Elias P. Gouvea ◽  
Roberto Esporcatte ◽  
Gustavo Luiz G. Almeida ◽  
...  
Keyword(s):  
Heart Failure ◽  
Differential Expression ◽  
Interleukin 6 ◽  
Severe Heart Failure ◽  
Factor Α ◽  
Necrosis Factor

Differential expression of potassium channels and abnormal conduction in experimental tachycardia-induced heart failure

2012 ◽  
Vol 385 (5) ◽  
pp. 473-480 ◽  
Author(s):  
Christoph Birner ◽  
Oliver Husser ◽  
Andreas Jeron ◽  
Munhie Rihm ◽  
Sabine Fredersdorf ◽  
...  
Keyword(s):  
Heart Failure ◽  
Potassium Channels ◽  
Differential Expression

scholarly journals Differential DNA Methylation Correlates with Differential Expression of Angiogenic Factors in Human Heart Failure

PLoS ONE ◽  
2010 ◽  
Vol 5 (1) ◽  
pp. e8564 ◽  
Author(s):  
Mehregan Movassagh ◽  
Mun-Kit Choy ◽  
Martin Goddard ◽  
Martin R. Bennett ◽  
Thomas A. Down ◽  
...  
Keyword(s):  
Heart Failure ◽  
Dna Methylation ◽  
Differential Expression ◽  
Human Heart ◽  
Angiogenic Factors ◽  
Human Heart Failure

scholarly journals Differential expression of Gs and Gi in mice with homocysteinemic heart failure

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Thomas Paul Vacek ◽  
Karni Singh Moshal ◽  
Utpal Sen ◽  
Neetu Tyagi ◽  
Mesia Steed ◽  
...  
Keyword(s):  
Heart Failure ◽  
Differential Expression
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