scholarly journals TGF‐β/Smad and JAK/STAT pathways are involved in the anti‐fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis

2020 ◽  
Vol 24 (9) ◽  
pp. 5224-5237 ◽  
Author(s):  
Shizan Xu ◽  
Yuqing Mao ◽  
Jianye Wu ◽  
Jiao Feng ◽  
Jingjing Li ◽  
...  
Keyword(s):  
Propylene Glycol ◽  
Hepatic Fibrosis ◽  
Sodium Sulphate ◽  
Propylene Glycol Alginate

scholarly journals Propylene glycol alginate sodium sulphate attenuates LPS-induced acute lung injury in a mouse model

2019 ◽  
Vol 25 (8) ◽  
pp. 513-521 ◽  
Author(s):  
Peng Zhao ◽  
Guoliang Liu ◽  
Yunfeng Cui ◽  
Xufang Sun
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Propylene Glycol ◽  
Inflammatory Cytokines ◽  
Sodium Sulphate ◽  
Aspartate Transaminase ◽  
Serum Alanine Aminotransferase ◽  
Nitrogen Levels ◽  
Cytokines And Chemokines ◽  
Propylene Glycol Alginate

Propylene glycol alginate sodium sulphate, a sulphated polysaccharide, has been used to treat hyperlipidaemia and ischaemia–reperfusion injury of liver. This study aimed to investigate the effect of propylene glycol alginate sodium sulphate on LPS-induced acute lung injury. Propylene glycol alginate sodium sulphate was injected intraperitoneally into male C57BL/6 mice with or without LPS administration. Survival rates were calculated. Serum, bronchoalveolar lavage fluid and lung tissues were collected to determine lung histology, wet/dry ratio, Evans blue albumin permeability, protein levels, the counts of immune cells and the levels of inflammatory cytokines and chemokines. Serum alanine aminotransferase, aspartate transaminase, creatinine and blood urea nitrogen levels were also measured. Additionally, NF-κB signalling was detected in the lung. Propylene glycol alginate sodium sulphate treatment significantly improved the survival of mice suffering from LPS. Lung histological injury, wet/dry ratio, Evans blue albumin permeability, neutrophils and the inflammatory cytokines and chemokines were significantly reduced by propylene glycol alginate sodium sulphate treatment. NF-κB signalling was significantly inhibited by propylene glycol alginate sodium sulphate in the lung of mice subjected to LPS. Furthermore, serum alanine aminotransferase, aspartate transaminase, creatinine and blood urea nitrogen levels were also significantly decreased after propylene glycol alginate sodium sulphate administration. This study suggests that NF-κB signalling and inhibition of pro-inflammatory cytokines, chemokines and neutrophil accumulation may be involved in the process of acute lung injury attenuation by propylene glycol alginate sodium sulphate.

Phase separation behavior and characterization of ovalbumin and propylene glycol alginate complex coacervates

2020 ◽  
Vol 108 ◽  
pp. 105978 ◽  
Author(s):  
Wenjie Zou ◽  
Fayez Khalaf Mourad ◽  
Xinyue Zhang ◽  
Dong U. Ahn ◽  
Zhaoxia Cai ◽  
...  
Keyword(s):  
Phase Separation ◽  
Propylene Glycol ◽  
Propylene Glycol Alginate ◽  
Phase Separation Behavior ◽  
Separation Behavior

Dietary effects of propylene glycol alginate in humans

1991 ◽  
Vol 8 (3) ◽  
pp. 225-236 ◽  
Author(s):  
D. M. W. Anderson ◽  
W. G. Brydon ◽  
M. A. Eastwood ◽  
D. M. Sedgwick
Keyword(s):  
Propylene Glycol ◽  
Dietary Effects ◽  
Propylene Glycol Alginate

The construction of resveratrol-loaded protein–polysaccharide–tea saponin complex nanoparticles for controlling physicochemical stability and in vitro digestion

2020 ◽  
Vol 11 (11) ◽  
pp. 9973-9983
Author(s):  
Yang Wei ◽  
Chang Li ◽  
Lei Dai ◽  
Liang Zhang ◽  
Jinfang Liu ◽  
...  
Keyword(s):  
Propylene Glycol ◽  
Ternary Complex ◽  
In Vitro Digestion ◽  
The Novel ◽  
Tea Saponin ◽  
Physicochemical Stability ◽  
Propylene Glycol Alginate

The novel zein–propylene glycol alginate (PGA)–tea saponin (TS) ternary complex nanoparticles were fabricated to deliver resveratrol.

Anticoagulant and FGF/FGFR signal activating activities of the heparinoid propylene glycol alginate sodium sulfate and its oligosaccharides

2016 ◽  
Vol 136 ◽  
pp. 641-648 ◽  
Author(s):  
Jian Wu ◽  
Meng Zhang ◽  
Yiran Zhang ◽  
Yangyang Zeng ◽  
Lijuan Zhang ◽  
...  
Keyword(s):  
Propylene Glycol ◽  
Sodium Sulfate ◽  
Propylene Glycol Alginate
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