scholarly journals Spatial relationship between telocytes, interstitial cells of Cajal and the enteric nervous system in the human ileum and colon

2020 ◽  
Vol 24 (6) ◽  
pp. 3399-3406 ◽  
Author(s):  
Béla Veress ◽  
Bodil Ohlsson
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Interstitial Cells Of Cajal ◽  
Spatial Relationship ◽  
Interstitial Cells ◽  
Cells Of Cajal

scholarly journals Neurons and a Subset of Interstitial Cells of Cajal in the Enteric Nervous System Highly Express Stam2 Gene

2011 ◽  
Vol 295 (1) ◽  
pp. 113-120 ◽  
Author(s):  
Katarina Kapuralin ◽  
Chris Van Ginneken ◽  
Marija Curlin ◽  
Jean-Pierre Timmermans ◽  
Srecko Gajovic
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Cells Of Cajal

scholarly journals Abnormalities of the intestinal pacemaker cells, enteric neurons, and smooth muscle in intestinal atresia

2019 ◽  
Vol 11 (03) ◽  
pp. 180-185 ◽  
Author(s):  
Radhika krishna OH ◽  
Mohammed Abdul Aleem ◽  
Geetha Kayla
Keyword(s):  
Nervous System ◽  
Small Bowel ◽  
Enteric Nervous System ◽  
Gastrointestinal Motility ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Enteric Neurons ◽  
Small Bowel Atresia ◽  
Bowel Atresia ◽  
Cells Of Cajal

Abstract BACKGROUND: Small bowel atresia is a congenital disorder that carves a substantial morbidity. Numerous postoperative gastrointestinal motility problems occur. The underlying cause of this motility disorder is still unclear. Interstitial cells of Cajal (ICC) play a major role in gastrointestinal motility. AIMS AND OBJECTIVES: To investigate the morphological changes of enteric nervous system and ICC in small bowel atresia. MATERIAL AND METHODS: Resected small bowel specimen from affected patients (n=15) were divided into three parts (proximal, distal, atretic). Standard histology and immunohistochemistry with anti C-KIT receptor antibody (CD117), calretinin and α-SMA was carried out. The density of myenteric ICCs in the proximal, atretic and distal parts was demonstrated by CD 117 while Calretinin was used for ganglion cells and nerve bundles, α-SMA highlighted muscle hypertrophy. RESULT AND CONCLUSION: The proximal and distal bowel revealed clear changes in the morphology and density of enteric nervous system and interstitial cells of Cajal..

Development of interstitial cells of Cajal in a full-term infant without an enteric nervous system

2001 ◽  
Vol 120 (2) ◽  
pp. 561-567 ◽  
Author(s):  
Jan D. Huizinga ◽  
Irene Berezin ◽  
Kanishka Sircar ◽  
Bryan Hewlett ◽  
Graeme Donnelly ◽  
...  
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Term Infant ◽  
Full Term ◽  
Full Term Infant ◽  
Cells Of Cajal

Innervation of interstitial cells of Cajal by vasoactive intestinal polypeptide containing nerves in canine colon

1990 ◽  
Vol 68 (7) ◽  
pp. 922-932 ◽  
Author(s):  
Irene Berezin ◽  
Jan D. Huizinga ◽  
Laura Farraway ◽  
Edwin E. Daniel
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Vasoactive Intestinal Polypeptide ◽  
Interstitial Cells Of Cajal ◽  
Circular Muscle ◽  
Interstitial Cells ◽  
Granular Vesicles ◽  
Cells Of Cajal ◽  
Large Granular Vesicles ◽  
Intestinal Polypeptide

The hypothesis was tested, through structural and functional studies, that interstitial cells of Cajal receive and can respond to direct innervation from nerves containing the vasoactive intestinal polypeptide neuromediator. The submucosal network of interstitial cells of Cajal has been postulated to provide pacemaking activity for the circular muscle and to be involved in neurotransmission from noradrenergic, noncholinergic nerves for which vasoactive intestinal polypeptide is a putative mediator. The distribution of vasoactive intestinal polypeptide and substance P immunoreactive material in nerve profiles of the enteric nervous system of the canine colon was examined. In addition, electrophysiological studies were done on the interstitial cells bordering the submucosal side of the circular muscle layer after they were electrically isolated using heptanol. The vasoactive intestinal polypeptide immunoreactivity, located exclusively in nerve large granular vesicles, was found throughout the enteric nervous system (myenteric plexus, submucous plexus, and circular muscle – submucosa interface). The highest proportion (38% compared with 22–24%) of profiles of large granular vesicles with vasoactive intestinal polypeptide immunoreactivity was found in nerve profiles of the circular muscle – submucosa interface. In contrast, substance P immunoreactivity was found in nerve profiles of myenteric plexus (33% of large granular vesicles were positive) but not associated with submucosal interstitial cell nerve network. The vasoactive intestinal polypeptide hyperpolarized interstitial cells by 9 mV when electrically isolated by 1 mM heptanol and markedly reduced (about 50%) their input membrane resistance. We conclude that the distribution of vasoactive intestinal polypeptide immunoreactivity and its action are consistent with a postulated role of the interstitial cells as a major site of neurally mediated inhibition of colonic pacemaker activity.Key words: enteric nervous system, interstitial cells of Cajal, inhibitory junction potential, nonadrenergic noncholinergic nerves.

Decreased density of interstitial cells of cajal and malformations of the enteric nervous system in patients with slow transit consitpation and megacolon

2001 ◽  
Vol 120 (5) ◽  
pp. A332
Author(s):  
Thilo Wedel ◽  
Juliane Spiegler ◽  
Stefan Schrader ◽  
Hanno Von Koschitzky ◽  
Uwe J. Roblick ◽  
...  
Keyword(s):  
Nervous System ◽  
Enteric Nervous System ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Slow Transit ◽  
Cells Of Cajal
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