scholarly journals Cyclin G2 regulates canonical Wnt signalling via interaction with Dapper1 to attenuate tubulointerstitial fibrosis in diabetic nephropathy

2020 ◽  
Vol 24 (5) ◽  
pp. 2749-2760 ◽  
Author(s):  
Chenyang Zhao ◽  
Jinlan Gao ◽  
Sen Li ◽  
Qi Liu ◽  
Xiaoyu Hou ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Wnt Signalling ◽  
Tubulointerstitial Fibrosis ◽  
Cyclin G2 ◽  
Canonical Wnt

scholarly journals Corrigendum to “Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling”

2019 ◽  
Vol 2019 ◽  
pp. 1-1
Author(s):  
Chenyang Zhao ◽  
Jinlan Gao ◽  
Sen Li ◽  
Qi Liu ◽  
Xiaoyu Hou ◽  
...  
Keyword(s):  
Wnt Signalling ◽  
Cyclin G2 ◽  
Canonical Wnt

CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy

FEBS Letters ◽  
2011 ◽  
Vol 585 (3) ◽  
pp. 531-538 ◽  
Author(s):  
Brian Rooney ◽  
Helen O‧Donovan ◽  
Andrew Gaffney ◽  
Marie Browne ◽  
Noel Faherty ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Mesangial Cells ◽  
Wnt Signalling ◽  
Canonical Wnt

scholarly journals Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Chenyang Zhao ◽  
Jinlan Gao ◽  
Sen Li ◽  
Qi Liu ◽  
Xiaoyu Hou ◽  
...  
Keyword(s):  
Cell Cycle Progression ◽  
Mesangial Cells ◽  
Protective Role ◽  
Wnt Signalling ◽  
Glomerular Mesangial Cells ◽  
Cycle Progression ◽  
Cyclin G2 ◽  
Canonical Wnt ◽  
Related Proteins ◽  
Insight Into

Recent data has shown that cyclin G2 (CCNG2) is an atypical cyclin that inhibits cell cycle progression and is often dysregulated in human cancers. The involvement of cyclin G2 in the occurrence and development of diabetic nephropathy (DN) has not been determined. In the present study, we conducted cyclin G2 knockout studies to determine whether this protein regulates glomerulosclerosis in DN mice. We found that cyclin G2 regulated the expression of renal glomerulosclerosis-related proteins via the canonical Wnt signalling pathway in glomerular mesangial cells. A cyclin G2 deficiency resulted in more severe renal injury in DN mice. These findings provided new insight into the pathogenesis of DN, revealing that cyclin G2 has a protective role in glomerulosclerosis and is a potential new target for the prevention and treatment of DN.

scholarly journals Association Analysis of Canonical Wnt Signalling Genes in Diabetic Nephropathy

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e23904 ◽  
Author(s):  
David H. Kavanagh ◽  
David A. Savage ◽  
Christopher C. Patterson ◽  
Amy Jayne McKnight ◽  
John K. Crean ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Association Analysis ◽  
Wnt Signalling ◽  
Canonical Wnt
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