scholarly journals Ethyl pyruvate attenuates ventilation‐induced diaphragm dysfunction through high‐mobility group box‐1 in a murine endotoxaemia model

2019 ◽  
Vol 23 (8) ◽  
pp. 5679-5691 ◽  
Author(s):  
Yung‐Yang Liu ◽  
Ning‐Hung Chen ◽  
Chih‐Hao Chang ◽  
Shih‐Wei Lin ◽  
Kuo‐Chin Kao ◽  
...  
Keyword(s):  
Ethyl Pyruvate ◽  
High Mobility ◽  
High Mobility Group ◽  
Diaphragm Dysfunction

scholarly journals Ethyl pyruvate attenuates murine allergic rhinitis partly by decreasing high mobility group box 1 release

2015 ◽  
Vol 240 (11) ◽  
pp. 1490-1499 ◽  
Author(s):  
Shan Chen ◽  
Yanjun Wang ◽  
Guoqing Gong ◽  
Jianjun Chen ◽  
Yongzhi Niu ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Ethyl Pyruvate ◽  
High Mobility ◽  
High Mobility Group

scholarly journals Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4/NF-κB Pathway after Traumatic Brain Injury in the Rat

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Xingfen Su ◽  
Handong Wang ◽  
Jinbing Zhao ◽  
Hao Pan ◽  
Lei Mao
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Ethyl Pyruvate ◽  
Apoptotic Cell ◽  
High Mobility ◽  
High Mobility Group ◽  
Male Rats ◽  
Vehicle Group ◽  
Secondary Brain Injury ◽  
Protective Effects

Ethyl pyruvate (EP) has demonstrated neuroprotective effects against acute brain injury through its anti-inflammatory action. The nuclear protein high-mobility group box 1 (HMGB1) can activate inflammatory pathways when released from dying cells. This study was designed to investigate the protective effects of EP against secondary brain injury in rats after Traumatic Brain Injury (TBI). Adult male rats were randomly divided into three groups: (1) Sham + vehicle group, (2) TBI + vehicle group, and (3) TBI + EP group (n=30per group). Right parietal cortical contusion was made by using a weight-dropping TBI method. In TBI + EP group, EP was administered intraperitoneally at a dosage of 75 mg/kg at 5 min, 1 and 6 h after TBI. Brain samples were harvested at 24 h after TBI. We found that EP treatment markedly inhibited the expressions of HMGB1 and TLR4, NF-κB DNA binding activity and inflammatory mediators, such as IL-1β, TNF-αand IL-6. Also, EP treatment significantly ameliorated beam walking performance, brain edema, and cortical apoptotic cell death. These results suggest that the protective effects of EP may be mediated by the reduction of HMGB1/TLR4/NF-κB-mediated inflammatory response in the injured rat brain.

scholarly journals Ethyl Pyruvate Attenuates Spinal Cord Ischemic Injury with a Wide Therapeutic Window through Inhibiting High-mobility Group Box 1 Release in Rabbits

2009 ◽  
Vol 110 (6) ◽  
pp. 1279-1286 ◽  
Author(s):  
Qiang Wang ◽  
Qian Ding ◽  
Yiming Zhou ◽  
Xingchun Gou ◽  
Lichao Hou ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Motor Neurons ◽  
Ethyl Pyruvate ◽  
High Mobility ◽  
Ischemic Injury ◽  
High Mobility Group ◽  
Therapeutic Window ◽  
Enzyme Linked Immunosorbent Assay ◽  
Spinal Cord Tissue ◽  
Spinal Cord Segment

Background Ethyl pyruvate (EP) has been reported to offer a protective effect against ischemic injury through its antiinflammatory action. The nuclear protein high-mobility group box 1 (HMGB1) can activate inflammatory pathways when released from ischemic cells. This study was designed to investigate the neuroprotective effect of EP against spinal cord ischemic injury and the potential role of HMGB1 in this process. Methods EP was administered at various time points before or after 20 min of spinal cord ischemia in male New Zealand rabbits. All animals were sacrificed at 72 h after reperfusion with modified Tarlov criteria, and the spinal cord segment (L4) was harvested for histopathological examination and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling staining. The HMGB1 levels in serum and spinal cord tissue were analyzed by enzyme-linked immunosorbent assay. Results The treatment of EP at 30 min before ischemia or at 6 h after reperfusion significantly improved the hind-limb motor function scores and increased the numbers of normal motor neurons, which was accompanied with reduction of the number of apoptotic neurons and levels of HMGB1 in serum and spinal cord tissue. The HMGB1 contents of spinal cord tissue correlated well with the numbers of apoptotic motor neurons in the anterior spinal cord at 72 h after reperfusion. Conclusion These results suggest that EP affords a strong protection against the transient spinal cord ischemic injury with a wide therapeutic window through inhibition of HMGB1 release.

The Effect of Ethyl Pyruvate on High Mobility Group Box I and Oxidative Stress in Induced Rheumatoid Arthritis in Rats

2019 ◽  
Vol 87 (June) ◽  
pp. 2547-2554
Author(s):  
HADEER S. SALAH, M.Sc. OMNIA S. EL-DEEB, M.D. ◽  
SAAD EL-DEEN A. ABO EL-NOEMAN, M.D NAGAH K. GAAFAR, M.D.
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Ethyl Pyruvate ◽  
High Mobility ◽  
High Mobility Group ◽  
And Oxidative Stress
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