scholarly journals A positive feedback loop between ZNF205‐AS1 and EGR4 promotes non‐small cell lung cancer growth

2018 ◽  
Vol 23 (2) ◽  
pp. 1495-1508 ◽  
Author(s):  
Susu He ◽  
Jian Lin ◽  
Youzu Xu ◽  
Ling Lin ◽  
Jiaxi Feng
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Small Cell ◽  
Cancer Growth ◽  
Small Cell Lung ◽  
Positive Feedback Loop

scholarly journals Correction: Active PLK1-driven metastasis is amplified by TGF-β signaling that forms a positive feedback loop in non-small cell lung cancer

Oncogene ◽  
2019 ◽  
Vol 39 (4) ◽  
pp. 951-951
Author(s):  
Sol-Bi Shin ◽  
Hay-Ran Jang ◽  
Rong Xu ◽  
Jae-Yeon Won ◽  
Hyungshin Yim
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Small Cell ◽  
Small Cell Lung ◽  
Positive Feedback Loop

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Positive feedback loop of lncRNA LINC01296/miR-598/Twist1 promotes non-small cell lung cancer tumorigenesis

2018 ◽  
Vol 234 (4) ◽  
pp. 4563-4571 ◽  
Author(s):  
Lijuan Xu ◽  
Bin Wei ◽  
Hongxia Hui ◽  
Yuan Sun ◽  
Yangqing Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Small Cell ◽  
Small Cell Lung ◽  
Positive Feedback Loop

scholarly journals MiR-199a-5p–HIF-1α-STAT3 Positive Feedback Loop Contributes to the Progression of Non-Small Cell Lung Cancer

2021 ◽  
Vol 8 ◽  
Author(s):  
Xingping Yang ◽  
Yuzhen Zheng ◽  
Jian Tan ◽  
Renjiang Tian ◽  
Piao Shen ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Small Cell ◽  
Luciferase Assay ◽  
Migration And Invasion ◽  
Small Cell Lung ◽  
Positive Feedback Loop

Background: Non-small cell lung cancer (NSCLC) is the most common malignancy worldwide. MiR-199a-5p has been reported to play important roles in multiple tumors, inclusive of NSCLC. However, little is definitively known pertaining to its explicit mechanism of action in NSCLC.Methods: The expressions of miR-199a-5p and hypoxia-inducible factor-1α (HIF-1α) mRNA were quantified employing qRT-PCR. H1299 and A549 cells were transiently transfected with miR-199a-5p mimics or inhibitors. Then, CCK-8 assays, flow cytometry analysis, and Transwell assay were performed for detecting cell proliferation, cell cycle, apoptosis, migration, and invasion of NSCLC cells, respectively. HIF-1α, signal transducer and activator of transcription 3 (STAT3), and p-STAT3 expressions were detected via Western blotting. Bioinformatic analysis and dual-luciferase assay were performed to investigate the interactions among miR-199a-5p, HIF-1α, and STAT3. Xenograft models were established with nude mice for further analyzing the bevacizumab resistance of NSCLC cells.Results: MiR-199a-5p expression was markedly attenuated in NSCLC tissues and cell lines. Overexpression of miR-199a-5p repressed the proliferation, migration, and invasion but induced the apoptosis of NSCLC cells. HIF-1α was identified as a direct target of miR-199a-5p. There was a positive feedback loop among miR-199a-5p, HIF-1α, and STAT3. Co-transfection of HIF-1α or STAT3 overexpression plasmids counteracted the effects of miR-199a-5p. In vivo experiments indicated that the feedback loop was in association with the bevacizumab resistance of NSCLC cells.Conclusion: MiR-199a-5p blocked the progression of NSCLC and sensitized NSCLC cells to bevacizumab by suppressing HIF-1α and STAT3, while the HIF-1α/STAT3 axis suppressed the expression of miR-199a-5p, which forms a positive feedback loop to promote the sustaining progression of NSCLC.

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