scholarly journals Fibroblast growth factor 21 facilitates peripheral nerve regeneration through suppressing oxidative damage and autophagic cell death

2018 ◽  
Vol 23 (1) ◽  
pp. 497-511 ◽  
Author(s):  
Yingfeng Lu ◽  
Rui Li ◽  
Junyi Zhu ◽  
Yanqing Wu ◽  
Duohui Li ◽  
...  
Keyword(s):  
Cell Death ◽  
Growth Factor ◽  
Oxidative Damage ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Fibroblast Growth Factor ◽  
Peripheral Nerve Regeneration ◽  
Autophagic Cell Death ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth

Acidic Fibroblast Growth Factor Enhances Peripheral Nerve Regeneration in Vivo

1989 ◽  
Vol 83 (6) ◽  
pp. 1020-1021 ◽  
Author(s):  
Peter G. Cordeiro ◽  
Brooke R. Seckel ◽  
Stuart A. Lipton ◽  
Patricia A. DʼAmore ◽  
John Wagner ◽  
...  
Keyword(s):  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Fibroblast Growth Factor ◽  
Peripheral Nerve Regeneration ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor

scholarly journals Fibroblast Growth Factor 13 Facilitates Peripheral Nerve Regeneration through Maintaining Microtubule Stability

2021 ◽  
Vol 2021 ◽  
pp. 1-15
Author(s):  
Rui Li ◽  
Xuetao Tao ◽  
Minghong Huang ◽  
Yan Peng ◽  
Jiahong Liang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Fibroblast Growth Factor ◽  
Nerve Repair ◽  
Peripheral Nerve Regeneration ◽  
Fibroblast Growth ◽  
Promising Alternative ◽  
Microtubule Stability

Peripheral nerve injury (PNI), resulting in the impairment of myelin sheaths and axons, seriously affects the transmission of sensory or motor nerves. Growth factors (GFs) provide a biological microenvironment for supporting nerve regrowth and have become a promising alternative for repairing PNI. As one number of intracellular growth factor family, fibroblast growth factor 13 (FGF13) was regard as a microtubule-stabilizing protein for regulating cytoskeletal plasticity and neuronal polarization. However, the therapeutic efficiency and underlying mechanism of FGF13 for treating PNI remained unknown. Here, the application of lentivirus that overexpressed FGF13 was delivered directly to the lesion site of transverse sciatic nerve for promoting peripheral nerve regeneration. Through behavioral analysis and histological and ultrastructure examinations, we found that FGF13 not only facilitated motor and sense functional recovery but also enhanced axon elongation and remyelination. Furthermore, pretreatment with FGF13 also promoted Schwann cell (SC) viability and upregulated the expression cellular microtubule-associated proteins in vitro PNI model. These data indicated FGF13 therapeutic effect was closely related to maintain cellular microtubule stability. Thus, this work provides the evident that FGF13-medicated microtubule stability is necessary for promoting peripheral nerve repair following PNI, highlighting the potential therapeutic value of FGF13 on ameliorating injured nerve recovery.

Fibroblast growth factor effects on peripheral nerve regeneration in a silicone chamber model

1988 ◽  
Vol 20 (3) ◽  
pp. 320-330 ◽  
Author(s):  
N. Danielsen ◽  
B. Pettmann ◽  
H. L. Vahlsing ◽  
M. Manthorpe ◽  
Silvio Varon
Keyword(s):  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Fibroblast Growth Factor ◽  
Peripheral Nerve Regeneration ◽  
Fibroblast Growth ◽  
Chamber Model

Acidic Fibroblast Growth Factor Enhances Peripheral Nerve Regeneration in Vivo

1989 ◽  
Vol 83 (6) ◽  
pp. 1013-1019 ◽  
Author(s):  
Peter G. Cordeiro ◽  
Brooke R. Seckel ◽  
Stuart A. Lipton ◽  
Patricia A. DʼAmore ◽  
John Wagner ◽  
...  
Keyword(s):  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Fibroblast Growth Factor ◽  
Peripheral Nerve Regeneration ◽  
Fibroblast Growth ◽  
Acidic Fibroblast Growth Factor
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