scholarly journals The potential contribution and role of a blood platelets in autoimmune thyroid diseases

2018 ◽  
Vol 22 (12) ◽  
pp. 6386-6390
Author(s):  
Małgorzata Tomczyńska ◽  
Ireneusz Salata ◽  
Michał Bijak ◽  
Joanna Saluk-Bijak
Keyword(s):  
Blood Platelets ◽  
Thyroid Diseases ◽  
Potential Contribution ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

scholarly journals The role of selenium in the pathogenesis of thyroid disease

2019 ◽  
Vol 14 (4) ◽  
pp. 192-205 ◽  
Author(s):  
Ekaterina A. Troshina ◽  
Evgeniya S. Senyushkina ◽  
Maria A. Terekhova
Keyword(s):  
Immune Response ◽  
Thyroid Disease ◽  
Animal Experiments ◽  
Optimal Level ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Increased Risk ◽  
Combined Deficiency

The past few years have been actively discussing the role of individual macro- and micronutrients as factors regulating the functional activity of organs and systems and reducing the risk of developing a number of diseases, including thyroid diseases. Selenium is one of the most important and intensively studied at present microelements. According to several studies, its low plasma level is associated with an increased risk of developing autoimmune thyroid diseases. In animal experiments, it was shown that a combined deficiency of selenium and iodine leads to more pronounced hypothyroidism than iodine deficiency alone. Some authors believe that cretinism in the newborn is a consequence of the combined deficiency of these two elements in the mother. It is also important that the optimal level of selenium is necessary both to initiate an immune response and to regulate an excessive immune response, as well as chronic inflammation. The review article discusses the relationship between selenium and thyroid pathology, discusses the role of selenium in the physiology of the thyroid gland and in the development of autoimmune diseases. The biochemical aspects of the pathogenesis of thyroid disease are presented.

A potential role of TNFR gene polymorphisms in autoimmune thyroid diseases in the Tunisian population

Cytokine ◽  
2008 ◽  
Vol 43 (2) ◽  
pp. 110-113 ◽  
Author(s):  
Maha Kammoun-Krichen ◽  
Noura Bougacha-Elleuch ◽  
Kaouthar Makni ◽  
Mouna Mnif ◽  
Joumaa Jouida ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Potential Role ◽  
Thyroid Diseases ◽  
Tunisian Population ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

scholarly journals Role of the T and B lymphocytes in pathogenesis of autoimmune thyroid diseases

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Marta Rydzewska ◽  
Michał Jaromin ◽  
Izabela Elżbieta Pasierowska ◽  
Karlina Stożek ◽  
Artur Bossowski
Keyword(s):  
B Lymphocytes ◽  
Thyroid Diseases ◽  
T And B Lymphocytes ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

scholarly journals The role of common genetic markers in susceptibility to type 1 diabetes and autoimmune thyroid diseases

2011 ◽  
Vol 14 (2) ◽  
pp. 23-31 ◽  
Author(s):  
Ekaterina Alexandrovna Repina
Keyword(s):  
Type 1 Diabetes ◽  
Genetic Markers ◽  
Current Data ◽  
Thyroid Diseases ◽  
Single Patient ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

This review generalizes current data on the genes responsible for combined susceptibility to type 1 diabetes and autoimmune thyroid diseases. Analysisof the role of common genetic markers facilitates understanding their contribution to the development of each of the two or several concomitantautoimmune diseases affecting a single patient

scholarly journals The Role of Medical Staff in Shaping the Nutrition Habits in Patients with Autoimmunization Thyroid Diseases in Poland.

2021 ◽  
Author(s):  
Ewa Czubek ◽  
Piotr Romaniuk ◽  
Klaudia Alcer ◽  
Mirjana Varjacic
Keyword(s):  
Thyroid Disease ◽  
Medical Staff ◽  
Autoimmune Thyroid Disease ◽  
Eating Behaviour ◽  
Medical Personnel ◽  
Well Being ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

Abstract Background: Autoimmune thyroid diseases are the most common diseases in humans. Their pathogenesis is complex. Patients are searching for ways of coping with them condition, including diet modifications. The aim of this study was to assess the role of medical personnel in shaping eating habits in patients with autoimmune thyroid disease based on experiences declared by patients. Methods: There were 208 people that took part in the study, of which 205 were qualified for final analysis. The results showed that patients most often choose online sources, while medical personnel rank second as the source of information on dietary recommendations.Results: People with thyroid disease are statistically more likely to use dietitian advice than people without thyroid disease. The highest percentage of respondents decided to modify their nutrition due to their own initiative. In addition, patients with autoimmune thyroid disease are statistically more likely to consider changing their diet to improve their well-being. The connection between the source of advice and modification of eating behaviour was also noted.Conclusion: Thanks to the joint effort of medical staff, patients can receive reliable knowledge about their disease, treatment and nutrition adapted to their needs.Trial registration: approved by the Bioethics Committee of Medical University of Silesia in Katowice (opinion no.: PCN/0022/KB1/80/2).

scholarly journals The Role of 18F-FDG PET/CT in the Management of the Autoimmune Thyroid Diseases

2019 ◽  
Vol 10 ◽  
Author(s):  
Bogdan Małkowski ◽  
Zbigniew Serafin ◽  
Rafał Glonek ◽  
Szymon Suwała ◽  
Rita Łopatto ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals The mutual cooperation of blood platelets and lymphocytes in the development of autoimmune thyroid diseases

2018 ◽  
Vol 65 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Małgorzata Tomczyńska ◽  
Joanna Saluk-Bijak
Keyword(s):  
Immune Cell ◽  
Blood Platelets ◽  
Lymphocyte Activation ◽  
Thyroid Diseases ◽  
Specific Cell ◽  
Lymphocyte Function ◽  
Autoimmune Thyroid Diseases ◽  
Mutual Cooperation ◽  
Autoimmune Thyroid ◽  
Cell Functions

Autoimmune thyroid diseases include several distinct clinical entities and mainly concern Graves` disease and Hashimoto's thyroiditis. An incompetent immune response directed against the body’s own tissues and the production of antibodies against specific cell antigens, accompanied by chronic inflammation occur in autoimmune thyroid diseases. The autoimmune process is induced by difficult to identify genetic and environmental factors, and generates the development of concomitant diseases of other systems. The inflammatory mediators, high level of thyroid hormones, lymphocyte activation and other immune cells play an important role in the chronic course of these diseases.  Autoimmune thyroid diseases are caused by disruptions of T-cells and other cells functions. The autoantibodies react with target antigens in different kinds of cells, including blood platelets. The autoimmune processes can cause the increased activity different kinds of cells including blood platelets and lymphocytes. The activity of blood platelets and lymphocytes is reciprocally regulated. It is suggested that blood platelets can influence lymphocyte function by direct contact through the receptors and via soluble mediators. The platelet–immune cell interactions represent a hallmark of immunity, as they can potently enhance immune cell functions.

scholarly journals TGF-β Physiology as a Novel Therapeutic Target Regarding Autoimmune Thyroid Diseases: Where Do We Stand and What to Expect

Medicina ◽  
2021 ◽  
Vol 57 (6) ◽  
pp. 621
Author(s):  
Efstratios Kardalas ◽  
Spyridoula Maraka ◽  
Maria Papagianni ◽  
George Paltoglou ◽  
Charalampos Siristatidis ◽  
...  
Keyword(s):  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Thyroid Autoimmunity ◽  
Treatment Options ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Activation Pathways ◽  
Novel Therapeutic

Transforming growth factor beta (TGF-β), as a master regulator of immune response, is deeply implicated in the complex pathophysiology and development of autoimmune thyroid diseases. Based on the close interplay between thyroid autoimmunity and TGF-β, scientific interest was shifted to the understanding of the possible role of this molecule regarding the diagnosis, prognosis, and therapy of these diseases. The main aim of this review is to present research data about possible treatment options based on the role of TGF-β in thyroid autoimmunity. Suggested TGF-β-mediated therapeutic strategies regarding autoimmune thyroid diseases include either the enhancement of its immunosuppressive role or inhibition of its facilitatory role in thyroid autoimmunity. For example, the application of hr-TGF-β can be used to bolster the inhibitory role of TGF-β regarding the development of thyroid diseases, whereas anti-TGF-β antibodies and similar molecules could impede its immune-promoting effects by blocking different levels of TGF-β biosynthesis and activation pathways. In conclusion, TGF-β could evolve to a promising, novel therapeutic tool for thyroid autoimmunity.

The role of hereditary and environmental factors in autoimmune thyroid diseases

2012 ◽  
Vol 153 (26) ◽  
pp. 1013-1022 ◽  
Author(s):  
Csaba Balázs
Keyword(s):  
Environmental Factors ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Thyroid Autoimmunity ◽  
Thyroid Diseases ◽  
Thyroid Peroxidase ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Histocompatibility Complex

Autoimmune thyroid diseases are the most common organ-specific autoimmune disorders affecting 5% to 10% of the population in Western countries. The clinical presentation varies from hyperthyroidism in Graves’ disease to hypothyroidism in Hashimoto’s thyroiditis. While the exact etiology of thyroid autoimmunity is not known, the interaction between genetic susceptibility and environmental factors appears to be of fundamental importance to initiate the process of thyroid autoimmunity. The identified autoimmune thyroid disease susceptibility genes include immune-modulating genes, such as the major histocompatibility complex, and thyroid-specific genes, including TSH receptor, thyroglobulin and thyroid peroxidase. The majority of the anti-TSH-receptor antibodies have a stimulating capacity and are responsible for hyperthyroidism. The anti-thyroglobulin- and anti-thyroid peroxidase antibodies belonging to the catalytic type of antibodies destroy the thyrocytes resulting in hypothyroidism. The appearance of anti-thyroid peroxidase antibodies precedes the induction of thyroiditis and the manifestation of hypothyroidism. The molecular analysis of thyroglobulin gene polymorphism is important in the mechanism of autoimmune thyroiditis. The autoantigen presentation by major histocompatibility complex molecules is a key point of the autoimmune mechanism. It has been shown that a HLA-DR variant containing arginine at position 74 of the DRβ1 chain confers a strong genetic susceptibility to autoimmune thyroid diseases, Graves’ disease and Hashimoto’s thyroiditis, while glutamine at position DRβ1-74 is protective. Human thyroglobulin 2098 peptide represents a strong and specific DRβ1-Arg74 binder, while a non-binding control peptide, thyroglobulin 2766 fails to induce this response. Moreover, thyroglobulin 2098 stimulated T-cells from individuals who were positive for thyroglobulin antibodies, demonstrating that thyroglobulin 2098 is an immunogenic peptide capable of being presented in vivo and activating T-cells in autoimmune thyroid diseases. Taken together these findings suggest that thyroglobulin 2098, a strong and specific binder to the disease-associated HLA-DRβ1-Arg74, is a major human T-cell epitope and it participates in the pathomechanism of the autoimmune thyroid disease. The exact nature of the role of environmental factors in the autoimmune thyroid disease is still not well known, but the importance of several factors such as iodine, drugs and infections has been reported. Further knowledge of the precise mechanisms of interaction between environmental factors and genes in inducing thyroid autoimmunity could result in the development of new strategies for diagnosis, prevention and treatment. Orv. Hetil., 2012, 153, 1013–1022.

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