scholarly journals Elevated CRB 3 expression suppresses breast cancer stemness by inhibiting β‐catenin signalling to restore tamoxifen sensitivity

2018 ◽  
Vol 22 (7) ◽  
pp. 3423-3433 ◽  
Author(s):  
Pingping Li ◽  
Chen Feng ◽  
He Chen ◽  
Yina Jiang ◽  
Fang Cao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Stemness ◽  
Tamoxifen Sensitivity

CDK12 Promotes Breast Cancer Progression and Maintains Stemness by Activating c-myc/β -catenin Signaling

2020 ◽  
Vol 20 (2) ◽  
pp. 156-165 ◽  
Author(s):  
Fang Peng ◽  
Chuansheng Yang ◽  
Yanan Kong ◽  
Xiaojia Huang ◽  
Yanyu Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Lung Metastasis ◽  
Xenograft Model ◽  
Breast Cancer Cell Lines ◽  
Cell Renewal ◽  
Cancer Stemness ◽  
Mesenchymal Transition ◽  
Potential Biomarker

Background: CDK12 is a promising therapeutic target in breast cancer with an effective ability of maintaining cancer cell stemness. Objective: We aim to investigate the mechanism of CDK12 in maintaining breast cancer stemness. Methods: CDK12 expression level was accessed by using RT-qPCR and IHC. CDK12-altered breast cancer cell lines MDA-MB-231-shCDK12 and SkBr-3-CDK12 were then established. CCK8, colony formation assays, and xenograft model were used to value the effect of CDK12 on tumorigenicity. Transwell assay, mammosphere formation, FACS, and lung metastasis model in vivo were determined. Western blot further characterized the mechanism of CDK12 in breast cancer stemness through the c-myc/β-catenin pathway. Results: Our results showed a higher level of CDK12 exhibited in breast cancer samples. Tumor formation, cancer cell mobility, spheroid forming, and the epithelial-mesenchymal transition will be enhanced in the CDK12high group. In addition, CDK12 was associated with lung metastasis and maintained breast cancer cell stemness. CDK12high cancer cells presented higher tumorigenicity and a population of CD44+ subset compared with CDK12low cells. Our study demonstrated c-myc positively expressed with CDK12. The c-myc/β-catenin signaling was activated by CDK12, which is a potential mechanism to initiate breast cancer stem cell renewal and may serve as a potential biomarker of breast cancer prognosis. Conclusion: CDK12 overexpression promotes breast cancer tumorigenesis and maintains the stemness of breast cancer by activating c-myc/β-catenin signaling. Inhibiting CDK12 expression may become a potential therapy for breast cancer.

Estrogen can restore Tamoxifen sensitivity in breast cancer cells amidst the complex network of resistance

2017 ◽  
Vol 93 ◽  
pp. 1320-1325 ◽  
Author(s):  
Sepideh Mansouri ◽  
Leila Farahmand ◽  
Aysooda Hosseinzade ◽  
Zahra Eslami-S ◽  
Keivan Majidzadeh-A
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Complex Network ◽  
Breast Cancer Cells ◽  
Tamoxifen Sensitivity

Dopamine D1 receptor agonists inhibit lung metastasis of breast cancer reducing cancer stemness

2019 ◽  
Vol 859 ◽  
pp. 172499 ◽  
Author(s):  
Liang Yang ◽  
Ye Yao ◽  
Ling Yong ◽  
Yaoyao Feng ◽  
Hong Su ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lung Metastasis ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Cancer Stemness ◽  
Receptor Agonists

scholarly journals Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness

2020 ◽  
Vol 130 (9) ◽  
pp. 4607-4623 ◽  
Author(s):  
Haiquan Lu ◽  
Yangyiran Xie ◽  
Linh Tran ◽  
Jie Lan ◽  
Yongkang Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Stemness

scholarly journals Erratum: Functional analysis of MKP-1 and MKP-2 in breast cancer tamoxifen sensitivity

Oncotarget ◽  
2018 ◽  
Vol 9 (81) ◽  
pp. 35286-35286
Author(s):  
Kelly K. Haagenson ◽  
Jessica Wei Zhang ◽  
Zhengfan Xu ◽  
Malathy P.V. Shekhar ◽  
Gen Sheng Wu
Keyword(s):  
Breast Cancer ◽  
Functional Analysis ◽  
Tamoxifen Sensitivity

scholarly journals Chemotherapy Induces Breast Cancer Stemness in Association with Dysregulated Monocytosis

2018 ◽  
Vol 24 (10) ◽  
pp. 2370-2382 ◽  
Author(s):  
Liang Liu ◽  
Lin Yang ◽  
Wei Yan ◽  
Jing Zhai ◽  
Donald P. Pizzo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Stemness
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