scholarly journals Relative abundance of mature myostatin rather than total myostatin is negatively associated with bone mineral density in Chinese

2017 ◽  
Author(s):  
Long-Fei Wu ◽  
Dong-Cheng Zhu ◽  
Bing-Hua Wang ◽  
Yi-Hua Lu ◽  
Pei He ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Relative Abundance ◽  
Mineral Density ◽  
Negatively Associated

scholarly journals Blood lead and cadmium levels are negatively associated with bone mineral density in young female adults

2021 ◽  
Vol 79 (1) ◽  
Author(s):  
Jianfeng Lu ◽  
Ji Lan ◽  
Xiao’e Li ◽  
Zhongxin Zhu
Keyword(s):  
Bone Mineral Density ◽  
Young Adults ◽  
Bone Mineral ◽  
Subgroup Analysis ◽  
Blood Lead ◽  
Negative Association ◽  
Skewed Distribution ◽  
Mineral Density ◽  
Negatively Associated ◽  
Lead And Cadmium

Abstract Background The organ toxicities of lead and cadmium have been extensively studied; however, studies of their toxic effects on bone remain limited, especially in young adults. The objective of this study was to examine the associations of blood lead levels (BLL) and blood cadmium levels (BCL) with bone mineral density (BMD) among young adults. Methods We performed a cross-sectional study using the National Health and Nutrition Examination Survey 2011–2018 database. Because of the skewed distribution, BLL and BCL were Ln-transformed for analysis. Weighted multivariate regressions were performed to evaluate the associations between LnBLL and LnBCL and lumbar BMD. Subgroup analyses were further performed. Results A total of 3234 participants aged 20–35 years were included in this study. No significant association between LnBLL and lumbar BMD was found (β = − 5.6, 95%CI: − 13.5–2.3). However, in the subgroup analysis stratified by sex, this association became negative in women (β = − 18.2, 95%CI: − 29.9– − 6.4). Moreover, this negative association was more prominent in female blacks (β = − 35.5, 95%CI: − 63.4– − 7.6). On the other hand, a negative association between LnBCL and lumbar BMD was found (β = − 7.4, 95%CI: − 14.0– − 0.8). In the subgroup analysis stratified by sex, this negative association only existed in women (β = − 18.7, 95%CI: − 28.0– − 9.5). Moreover, this negative association was more prominent in female whites (β = − 31.1, 95%CI: − 46.2– − 16.1). Conclusions Our finding showed that both BLL and BCL were independently and negatively associated with lumbar BMD among young females, but not among young males.

Hepatic steatosis is negatively associated with bone mineral density in children

2021 ◽  
Author(s):  
Lauren F. Chun ◽  
Elizabeth L. Yu ◽  
Mary Catherine Sawh ◽  
Craig Bross ◽  
Jeanne Nichols ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Hepatic Steatosis ◽  
Bone Mineral ◽  
Mineral Density ◽  
Negatively Associated

Prudent and traditional dietary patterns are positively and negatively associated with bone mineral density in Iranian adults, respectively

2020 ◽  
pp. 1-11
Author(s):  
Aida Najafi ◽  
Siavash Babajafari ◽  
Mohammad-Hossein Dabbaghmanesh ◽  
Masoumeh Akhlaghi ◽  
Fatemeh Shafiee ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Dietary Patterns ◽  
Mean Difference ◽  
Leafy Vegetables ◽  
Mineral Density ◽  
Negatively Associated ◽  
Adjusted Means

Abstract. To assess the association of dietary patterns and bone mineral density (BMD), 340 healthy Iranian adults (mean age 41.5 ± 7.7 y; 79.1% female) participated in this cross-sectional study. Lumbar spine and femoral neck BMDs were measured using dual-energy X-ray absorptiometry. Dietary intakes were evaluated by a valid and reliable 168-item food frequency questionnaire, and three major dietary patterns were identified using principal component factor analysis. Mean values for lumbar spine and femoral neck BMDs in participants were 0.96 ± 0.13 and 0.92 ± 0.12 g/cm2, respectively. After controlling for age, body mass index, physical activity, energy intake, sunlight exposure, gender, education, employment status, supplement intake, and smoking in the analysis of covariance models, multivariable adjusted means of femoral neck BMD of participants in the highest tertile of the prudent pattern score (rich in green leafy vegetables, other vegetables, tomatoes, yellow vegetables, fruits and fruit juices, olives, nuts, fish, low-fat dairy products, and Doogh) were significantly higher than those in the lowest tertile (mean difference and 95% CI: 0.043 [0.003; 0.083] g/cm2, P = 0.032). In contrast, multivariable adjusted means of lumbar spine BMD of participants in the highest tertile of the traditional pattern score (high in Abgoosht, vegetable oils, salt, legumes, pickles, cruciferous vegetables, refined grains, potatoes, and organ meats) were significantly lower than those in the lowest tertile (mean difference and 95% CI: −0.057 [−0.098; −0.015] g/cm2, P = 0.003). The Western pattern was not associated with BMD. In conclusion, the prudent and traditional dietary patterns are positively and negatively associated with BMD in Iranian adults, respectively.

PYY is Negatively Associated with Bone Mineral Density in Exercising Women with Amenorrhea

2010 ◽  
Vol 42 ◽  
pp. 701 ◽  
Author(s):  
Rebecca J. Toombs ◽  
Jennifer L. Scheid ◽  
Nancy I. Williams ◽  
Mary Jane De Souza
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Negatively Associated ◽  
Exercising Women

scholarly journals The Oslo Health Study: A Dietary Index Estimating Frequent Intake of Soft Drinks and Rare Intake of Fruit and Vegetables Is Negatively Associated with Bone Mineral Density

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Arne Torbjørn Høstmark ◽  
Anne Johanne Søgaard ◽  
Kari Alvær ◽  
Haakon E. Meyer
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Fruits And Vegetables ◽  
Soft Drinks ◽  
Negative Association ◽  
Health Study ◽  
Distal Forearm ◽  
Mineral Density ◽  
Negatively Associated ◽  
Dietary Index

Background. Since nutritional factors may affect bone mineral density (BMD), we have investigated whether BMD is associated with an index estimating the intake of soft drinks, fruits, and vegetables.Methods. BMD was measured in distal forearm in a subsample of the population-based Oslo Health Study. 2126 subjects had both valid BMD measurements and answered all the questions required for calculating aDietary Index= the sum of intake estimates of colas and non-cola beverages divided by the sum of intake estimates of fruits and vegetables. We did linear regression analyses to study whether the Dietary Index and the single food items included in the index were associated with BMD.Results. There was a consistent negative association between the Dietary Index and forearm BMD. Among the single index components, colas and non-cola soft drinks were negatively associated with BMD. The negative association between the Dietary Index and BMD prevailed after adjusting for gender, age, and body mass index, length of education, smoking, alcohol intake, and physical activity.Conclusion. An index reflecting frequent intake of soft drinks and rare intake of fruit and vegetables was inversely related to distal forearm bone mineral density.

scholarly journals Bone mineral density and bone metabolism in postmenopausal women with type 2 diabetes in a Chinese community: a cross-sectional study

2020 ◽  
Author(s):  
Wu Han ◽  
Yufan Zhang ◽  
Wenbin Zhou ◽  
Guolong Zhang ◽  
Jindi Wang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Bone Formation ◽  
Bone Turnover ◽  
Bone Metabolism ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Negatively Associated

Abstract Background: There is growing evidence of a complex interaction between type 2 diabetes (T2DM) and osteoporosis. The purpose of this study was to further study the relationship between Bone turnover markers (BTMs) and fasting blood glucose (FBG) in postmenopausal patients with type 2 diabetes and to analyze the effect of hyperglycemia on bone metabolism.Methods: Six hundred and twelve (612) postmenopausal women were included, including one hundred and seven (107) subjects with T2DM and five hundred and five (505) subjects without diabetes. Bone mineral density (BMD) was measured by DXA (dual-energy X-ray absorptiometry). Markers of bone formation Type 1 collagen N-terminal peptide (P1NP) and resorption C-telopeptide of type l collagen (CTX) were quantified.Results: Compared to controls, postmenopausal women with diabetes had a higher prevalence of previous osteoporosis fracture (27.1% vs. 17.4% for diabetic and nondiabetic women, respectively) and a higher BMD. The P1NP level in women with T2DM was 49.451 ng/ml, while in N-DM individuals, it was 58.633 ng/ml, (p = 0.017). The CTX level in women with T2DM was 0.325 ng/ml, while in N-DM individuals, it was 0.412 ng/ml (p=0.039). In addition, P1NP was significantly negatively associated with age (β=-0.590; p= 0.002) and FBG (β=-1.950; p = 0.035). CTX was negatively associated with FBG (β=-0.029; p = 0.015).Conclusions: T2DM was associated with higher BMD and paradoxically, with an increased risk of fracture. Postmenopausal women with T2DM had lower bone turnover than controls. With increased levels of FBG, bone formation and bone resorption were reduced, and the overall bone turnover level was reduced.

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