scholarly journals Chronic kidney disease with comorbid cardiac dysfunction exacerbates cardiac and renal damage

2017 ◽  
Vol 22 (1) ◽  
pp. 628-645 ◽  
Author(s):  
Shan Liu ◽  
Bing H. Wang ◽  
Darren J. Kelly ◽  
Henry Krum ◽  
Andrew R. Kompa
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiac Dysfunction ◽  
Renal Damage

scholarly journals New Potential Biomarkers for Chronic Kidney Disease Management—A Review of the Literature

2020 ◽  
Vol 22 (1) ◽  
pp. 43
Author(s):  
Irina Lousa ◽  
Flávio Reis ◽  
Idalina Beirão ◽  
Rui Alves ◽  
Luís Belo ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Clinical Practice ◽  
Kidney Disease ◽  
Renal Damage ◽  
Recent Literature ◽  
Therapeutic Interventions ◽  
Review Of The Literature ◽  
Medical Need ◽  
Early Use ◽  
Reasonable Approach

The prevalence of chronic kidney disease (CKD) is increasing worldwide, and the mortality rate continues to be unacceptably high. The biomarkers currently used in clinical practice are considered relevant when there is already significant renal impairment compromising the early use of potentially successful therapeutic interventions. More sensitive and specific biomarkers to detect CKD earlier on and improve patients’ prognoses are an important unmet medical need. The aim of this review is to summarize the recent literature on new promising early CKD biomarkers of renal function, tubular lesions, endothelial dysfunction and inflammation, and on the auspicious findings from metabolomic studies in this field. Most of the studied biomarkers require further validation in large studies and in a broad range of populations in order to be implemented into routine CKD management. A panel of biomarkers, including earlier biomarkers of renal damage, seems to be a reasonable approach to be applied in clinical practice to allow earlier diagnosis and better disease characterization based on the underlying etiologic process.

scholarly journals Correlation of electrophoretic urine protein banding patterns with severity of renal damage in dogs with proteinuric chronic kidney disease

2018 ◽  
Vol 47 (3) ◽  
pp. 425-434 ◽  
Author(s):  
Jessica A. Hokamp ◽  
Sidney A. Leidy ◽  
Irina Gaynanova ◽  
Rachel E. Cianciolo ◽  
Mary B. Nabity
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Damage ◽  
Urine Protein ◽  
Banding Patterns

scholarly journals Cardiac Dysfunction in the 5/6 Ablation‐Infarction Model of Chronic Kidney Disease

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
James M Kuczmarski ◽  
Christopher R Martens ◽  
Shannon L Lennon‐Edwards ◽  
David G Edwards
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiac Dysfunction

scholarly journals Ligustrazine attenuates renal damage by inhibiting endoplasmic reticulum stress in diabetic nephropathy by inactivating MAPK pathways

RSC Advances ◽  
2018 ◽  
Vol 8 (39) ◽  
pp. 21816-21822 ◽  
Author(s):  
Hongling Yang ◽  
Shukun Wu
Keyword(s):  
Chronic Kidney Disease ◽  
Endoplasmic Reticulum ◽  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
Endoplasmic Reticulum Stress ◽  
Renal Damage ◽  
Mapk Pathways ◽  
The World

Diabetic nephropathy (DN) is a major cause of chronic kidney disease around the world.

scholarly journals Association between Protein-Bound Uremic Toxins and Asymptomatic Cardiac Dysfunction in Patients with Chronic Kidney Disease

Toxins ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 520 ◽  
Author(s):  
Shanmugakumar Chinnappa ◽  
Yu-Kang Tu ◽  
Yi Chun Yeh ◽  
Griet Glorieux ◽  
Raymond Vanholder ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiac Dysfunction ◽  
Serum Levels ◽  
Significant Negative Correlation ◽  
Cross Sectional Study ◽  
Left Ventricular ◽  
Uremic Toxins ◽  
Cross Sectional ◽  
The Individual

Although the relationship between protein-bound uremic toxins (PBUTs) and cardiac structure and cardiac mortality in chronic kidney disease (CKD) has been studied in the past, the association between cardiac dysfunction and PBUTs has not yet been studied. We therefore evaluated the association between impaired peak cardiac performance and the serum free and total concentrations of potentially cardiotoxic PBUTs. In a cross-sectional study of 56 male CKD patients (stages 2–5 (pre-dialysis)) who were asymptomatic with no known cardiac diseases or diabetes we measured peak cardiac power (CPOmax), aerobic exercise capacity (VO2max), and echocardiographic parameters of cardiac morphology and evaluated their association with PBUTs. The serum total and free concentrations of indoxyl sulfate (IXS), p-cresyl sulfate (PCS), p-cresyl glucuronide, indole acetic acid, and hippuric acid showed significant negative correlation with CPOmax and VO2max. IXS and PCS were independently associated with CPOmax and VO2max even after controlling for eGFR. No correlation between left ventricular mass index (LVMI) and PBUTs was seen. The present study for the first time has demonstrated the association between subclinical cardiac dysfunction in CKD and serum levels of a panel of PBUTs. Further studies are required to evaluate the mechanism of cardiotoxicity of the individual uremic toxins.

scholarly journals SUN-209 CHRONIC KIDNEY DISEASE CLASSIFICATION: IS THE CORRECT METHOD TO DEFINE RENAL DAMAGE OR IS IT JUST AN ILLUSION?

2019 ◽  
Vol 4 (7) ◽  
pp. S246
Author(s):  
F. TREVISANI ◽  
U. Capitanio ◽  
F. Di Marco ◽  
G. Dell'Antonio ◽  
A. Bettiga ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Damage ◽  
Disease Classification ◽  
Correct Method

SUPPRESSION OF SIRPα SIGNALING REPLICATES EXERCISE INDUCED REMODELING AND PREVENTS CARDIAC DYSFUNCTION IN CHRONIC KIDNEY DISEASE

2018 ◽  
Vol 71 (11) ◽  
pp. A932
Author(s):  
Giovanni Davogustto ◽  
Jiao Wu ◽  
William Mitch ◽  
Heinrich Taegtmeyer ◽  
Sandhya Thomas
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cardiac Dysfunction ◽  
Exercise Induced

scholarly journals Iron-restricted pair-feeding affects renal damage in rats with chronic kidney disease

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0172157
Author(s):  
Yoshiro Naito ◽  
Aya Senchi ◽  
Hisashi Sawada ◽  
Makiko Oboshi ◽  
Tetsuo Horimatsu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Renal Damage
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