scholarly journals Pannexin3 inhibits TNF-α-induced inflammatory response by suppressing NF-κB signalling pathway in human dental pulp cells

2016 ◽  
Vol 21 (3) ◽  
pp. 444-455 ◽  
Author(s):  
Fangfang Song ◽  
Hualing Sun ◽  
Yake Wang ◽  
Hongye Yang ◽  
Liyuan Huang ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Dental Pulp ◽  
Signalling Pathway ◽  
Dental Pulp Cells ◽  
Human Dental Pulp Cells ◽  
Tnf Α ◽  
Human Dental Pulp ◽  
Pulp Cells

TNF-α and LPS activate angiogenesis via VEGF and SIRT1 signalling in human dental pulp cells

2014 ◽  
Vol 48 (7) ◽  
pp. 705-716 ◽  
Author(s):  
M. R. Shin ◽  
S. K. Kang ◽  
Y. S. Kim ◽  
S. Y. Lee ◽  
S. C. Hong ◽  
...  
Keyword(s):  
Dental Pulp ◽  
Dental Pulp Cells ◽  
Human Dental Pulp Cells ◽  
Tnf Α ◽  
Human Dental Pulp ◽  
Pulp Cells

Pentraxin 3 Modulates the Inflammatory Response in Human Dental Pulp Cells

2018 ◽  
Vol 44 (12) ◽  
pp. 1826-1831 ◽  
Author(s):  
Yeon Kim ◽  
Jin-Sung Park ◽  
Hyun-Joo Park ◽  
Mi-Kyoung Kim ◽  
Yong-Il Kim ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Dental Pulp ◽  
Pentraxin 3 ◽  
Dental Pulp Cells ◽  
Human Dental Pulp Cells ◽  
Human Dental Pulp ◽  
Pulp Cells

TNF‐α differently regulates TRPV2 and TRPV4 channels in human dental pulp cells

2019 ◽  
Vol 52 (11) ◽  
pp. 1617-1628 ◽  
Author(s):  
J. Liu ◽  
Z. Zhao ◽  
J. Wen ◽  
Y. Wang ◽  
M. Zhao ◽  
...  
Keyword(s):  
Dental Pulp ◽  
Dental Pulp Cells ◽  
Human Dental Pulp Cells ◽  
Tnf Α ◽  
Human Dental Pulp ◽  
Pulp Cells

scholarly journals FK866 Protects Human Dental Pulp Cells against Oxidative Stress-Induced Cellular Senescence

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 271
Author(s):  
Chang Youp Ok ◽  
Sera Park ◽  
Hye-Ock Jang ◽  
Takashi Takata ◽  
Ok-Hee Lee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cellular Senescence ◽  
Dental Pulp ◽  
Premature Senescence ◽  
Dental Pulp Cells ◽  
Human Dental Pulp Cells ◽  
Tnf Α ◽  
Human Dental Pulp ◽  
Pulp Cells ◽  
Molecular Indicators

FK866 possesses various functional properties, such as anti-angiogenic, anti-cancer, and anti-inflammatory activities. We previously demonstrated that premature senescence of human dental pulp cells (hDPCs) was induced by hydrogen peroxide (H2O2). The present study aimed to investigate whether H2O2-induced premature senescence of hDPCs is affected by treatment with FK866. We found that FK866 markedly inhibited the senescent characteristics of hDPCs after exposure to H2O2, as revealed by an increase in the number of senescence-associated β-galactosidase (SA-β-gal)-positive hDPCs and the upregulation of the p21 and p53 proteins, which acts as molecular indicators of cellular senescence. Moreover, the stimulatory effects of H2O2 on cellular senescence are associated with oxidative stress induction, such as excessive ROS production and NADPH consumption, telomere DNA damage induction, and upregulation of senescence-associated secretory phenotype factors (IL-1β, IL-6, IL-8, COX-2, and TNF-α) as well as NF-κB activation, which were all blocked by FK866. Thus, FK866 might antagonize H2O2-induced premature senescence of hDPCs, acting as a potential therapeutic antioxidant by attenuating oxidative stress-induced pathologies in dental pulp, including inflammation and cellular senescence.

scholarly journals The Preparation and Characterization of Chitosan-Based Hydrogels Cross-Linked by Glyoxal

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2449
Author(s):  
Beata Kaczmarek-Szczepańska ◽  
Olha Mazur ◽  
Marta Michalska-Sionkowska ◽  
Krzysztof Łukowicz ◽  
Anna Maria Osyczka
Keyword(s):  
Thermal Stability ◽  
Tannic Acid ◽  
Dental Pulp ◽  
Blood Compatibility ◽  
Dental Pulp Cells ◽  
Preliminary Assessment ◽  
Human Dental Pulp Cells ◽  
Human Dental Pulp ◽  
Pulp Cells

In this study, hydrogels based on chitosan cross-linked by glyoxal have been investigated for potential medical applications. Hydrogels were loaded with tannic acid at different concentrations. The thermal stability and the polyphenol-releasing rate were determined. For a preliminary assessment of the clinical usefulness of the hydrogels, they were examined for blood compatibility and in the culture of human dental pulp cells (hDPC). The results showed that after immersion in a polyphenol solution, chitosan/glyoxal hydrogels remain nonhemolytic for erythrocytes, and we also did not observe the cytotoxic effect of hydrogels immersed in tannic acid (TA) solutions with different concentration. Tannic acid was successfully released from hydrogels, and its addition improved material thermal stability. Thus, the current findings open the possibility to consider such hydrogels in clinics.

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