scholarly journals Methylglyoxal induces cell death through endoplasmic reticulum stress-associated ROS production and mitochondrial dysfunction

2016 ◽  
Vol 20 (9) ◽  
pp. 1749-1760 ◽  
Author(s):  
Chi-Ming Chan ◽  
Duen-Yi Huang ◽  
Yi-Pin Huang ◽  
Shu-Hao Hsu ◽  
Lan-Ya Kang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Mitochondrial Dysfunction ◽  
Ros Production

scholarly journals Sophorolipid exhibits antifungal activity by ROS mediated endoplasmic reticulum stress and mitochondrial dysfunction pathways in Candida albicans

RSC Advances ◽  
2019 ◽  
Vol 9 (71) ◽  
pp. 41639-41648 ◽  
Author(s):  
Farazul Haque ◽  
Nitish Kumar Verma ◽  
Mohammad Alfatah ◽  
Swati Bijlani ◽  
Mani Shankar Bhattacharyya
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Endoplasmic Reticulum Stress ◽  
Er Stress ◽  
Mitochondrial Dysfunction ◽  
Ros Generation

Sophorolipid induces ROS generation in C. albicans leading to mitochondrial dysfunction and ER stress followed by the release of Ca2+ ions (from the ER lumen) that enter mitochondria and further magnify ROS generation leading to cell death.

scholarly journals The Natural Occurring Compounds Targeting Endoplasmic Reticulum Stress

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Hai Liu ◽  
Jianqiong Yang ◽  
Linfu Li ◽  
Weimei Shi ◽  
Xiaoliang Yuan ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Er Stress ◽  
Clinical Applications ◽  
Inflammatory Factors ◽  
Ros Production ◽  
Pharmacological Mechanism ◽  
Medical Benefits ◽  
Novel Strategy

ER stress has been implicated in pathophysiological development of many diseases. Persistent overwhelming stimuli trigger ER stress to initiate apoptosis, autophagy, and cell death. IRE1-JNK and eIF2α-CHOP signaling pathways are the two important players of ER stress, which is also modulated by ROS production, calcium disturbance, and inflammatory factors. ER stress has been developed as a novel strategy for diseases management. Recently, a vast of research focuses on the natural occurring compounds targeting ER stress, which results in medical benefits to human diseases. These small reported molecules mainly include polyphenols, alkaloids, and saponins. Many of them have been developed for use in clinical applications. To better understand the pharmacological mechanism of these molecules in ER stress in diseases, efforts have been made to discover and deliver medical merits. In this paper, we will summarize the natural occurring compounds targeting ER stress.

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

2011 ◽  
Vol 89 (7) ◽  
pp. 1031-1042 ◽  
Author(s):  
Tomohiro Umeda ◽  
Takami Tomiyama ◽  
Naomi Sakama ◽  
Saya Tanaka ◽  
Mary P. Lambert ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Mitochondrial Dysfunction ◽  
Amyloid Β

Minocycline prevents paraquat-induced cell death through attenuating endoplasmic reticulum stress and mitochondrial dysfunction

2012 ◽  
Vol 209 (3) ◽  
pp. 203-210 ◽  
Author(s):  
Chuen-Lin Huang ◽  
Yi-Chao Lee ◽  
Ying-Chen Yang ◽  
Tsun-Yung Kuo ◽  
Nai-Kuei Huang
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Mitochondrial Dysfunction

CUX1 controls endoplasmic reticulum stress and autophagy related cell death

2016 ◽  
Vol 54 (12) ◽  
pp. 1343-1404
Author(s):  
G Metzger ◽  
P Di Fazio ◽  
DK Bartsch ◽  
T Gress ◽  
TT Wissniowski
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endoplasmic Reticulum Stress ◽  
Related Cell
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