scholarly journals Lipid peroxidation and apoptotic response in rat brain areas induced by long‐term administration of nandrolone: the mutual crosstalk between ROS and NF ‐ kB

2016 ◽  
Vol 20 (4) ◽  
pp. 601-612 ◽  
Author(s):  
Emanuela Turillazzi ◽  
Margherita Neri ◽  
Daniela Cerretani ◽  
Santina Cantatore ◽  
Paola Frati ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Rat Brain ◽  
Apoptotic Response ◽  
Brain Areas ◽  
Term Administration

scholarly journals The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine

Antioxidants ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 37
Author(s):  
Jan Homolak ◽  
Ana Babic Perhoc ◽  
Ana Knezovic ◽  
Jelena Osmanovic Barilar ◽  
Davor Virag ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Small Intestine ◽  
Oral Administration ◽  
Redox Homeostasis ◽  
Intestinal Barrier ◽  
Redox System ◽  
Dissociation Rate ◽  
Term Administration ◽  
Male Wistar Rats

Galactose is a ubiquitous monosaccharide with important yet incompletely understood nutritive and physiological roles. Chronic parenteral d-galactose administration is used for modeling aging-related pathophysiological processes in rodents due to its ability to induce oxidative stress (OS). Conversely, chronic oral d-galactose administration prevents and alleviates cognitive decline in a rat model of sporadic Alzheimer’s disease, indicating that galactose may exert beneficial health effects by acting in the gut. The present aim was to explore the acute time-response of intestinal redox homeostasis following oral administration of d-galactose. Male Wistar rats were euthanized at baseline (n = 6), 30 (n = 6), 60 (n = 6), and 120 (n = 6) minutes following orogastric administration of d-galactose (200 mg/kg). The overall reductive capacity, lipid peroxidation, the concentration of low-molecular-weight thiols (LMWT) and protein sulfhydryls (SH), the activity of Mn and Cu/Zn superoxide dismutases (SOD), reduced and oxidized fractions of nicotinamide adenine dinucleotide phosphates (NADPH/NADP), and the hydrogen peroxide dissociation rate were analyzed in duodenum and ileum. Acute oral administration of d-galactose increased the activity of SODs and decreased intestinal lipid peroxidation and nucleophilic substrates (LMWT, SH, NADPH), indicating activation of peroxidative damage defense pathways. The redox system of the small intestine can acutely tolerate even high luminal concentrations of galactose (0.55 M), and oral galactose treatment is associated with a reduction rather than the increment of the intestinal OS. The ability of oral d-galactose to modulate intestinal OS should be further explored in the context of intestinal barrier maintenance, and beneficial cognitive effects associated with long-term administration of low doses of d-galactose.

Long-term administration of the antidepressant vilazodone modulates rat brain monoaminergic systems

2015 ◽  
Vol 99 ◽  
pp. 696-704 ◽  
Author(s):  
Mostafa El Mansari ◽  
Agnes Crnic ◽  
Chris Oosterhof ◽  
Pierre Blier
Keyword(s):  
Rat Brain ◽  
Term Administration

Long-term administration of citalopram reduces basal and stress-induced extracellular noradrenaline levels in rat brain

2007 ◽  
Vol 194 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Yukie Kawahara ◽  
Hiroshi Kawahara ◽  
Fumi Kaneko ◽  
Masatoshi Tanaka
Keyword(s):  
Rat Brain ◽  
Term Administration ◽  
Noradrenaline Levels

Effect of transient reduction of cerebral blood flow on membrane anisotropy and lipid peroxidation in different rat brain areas

1994 ◽  
Vol 25 (2) ◽  
pp. 161-168 ◽  
Author(s):  
Mira Melzacka ◽  
Nina Weiner ◽  
Christine Heim ◽  
Rainald Schmidt-Kastner ◽  
Maria Sieklucka ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Rat Brain ◽  
Brain Areas

scholarly journals Changes in alpha2 adrenoreceptors in various areas of the rat brain after long-term administration of “mu” and “kappa” opiate agonists

Life Sciences ◽  
1983 ◽  
Vol 33 ◽  
pp. 369-372 ◽  
Author(s):  
Charles B. Smith ◽  
Peggie J. Hollingsworth ◽  
Joann J. Geer ◽  
Hylan C. Moises
Keyword(s):  
Rat Brain ◽  
Term Administration

Effects of short- and long-term administration of fluoxetine on the monoamine content of rat brain

1992 ◽  
Vol 31 (4) ◽  
pp. 343-347 ◽  
Author(s):  
S CACCIA ◽  
C FRACASSO ◽  
S GARATTINI ◽  
G GUISO ◽  
S SARATI
Keyword(s):  
Rat Brain ◽  
Term Administration ◽  
Short And Long Term ◽  
Monoamine Content
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