scholarly journals Aberrant expression of Arpin in human breast cancer and its clinical significance

2015 ◽  
Vol 20 (3) ◽  
pp. 450-458 ◽  
Author(s):  
Xiangping Liu ◽  
Bin Zhao ◽  
Haibo Wang ◽  
Yu Wang ◽  
Mengdi Niu ◽  
...  
2005 ◽  
Vol 11 (12) ◽  
pp. 4357-4364 ◽  
Author(s):  
Huayi Huang ◽  
Jeff Groth ◽  
Khalid Sossey-Alaoui ◽  
Lesleyann Hawthorn ◽  
Stephanie Beall ◽  
...  

2020 ◽  
Vol 11 ◽  
Author(s):  
Xiaoxue Xie ◽  
Junying Zhang ◽  
Zhongyuan Shi ◽  
Wanmei Liu ◽  
Xinlei Hu ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Ayako Nakashoji ◽  
Tetsu Hayashida ◽  
Yuko Kawai ◽  
Masayuki Kikuchi ◽  
Rurina Watanuki ◽  
...  

First identified as a developmental gene, HOXB9 is also known to be involved in tumor biological processes, and its aberrant expression correlates with poor prognosis of various cancers. In this study, we isolated a homeodomain-less, novel HOXB9 variant (HOXB9v) from human breast cancer cell line-derived mRNA. We confirmed that the novel variant was produced from variationless HOXB9 genomic DNA. RT-PCR of mRNA isolated from clinical samples and reanalysis of publicly available RNA-seq data proved that the new transcript is frequently expressed in human breast cancer. Exogenous HOXB9v expression significantly enhanced the proliferation of breast cancer cells, and gene ontology analysis indicated that apoptotic signaling was suppressed in these cells. Considering that HOXB9v lacks key domains of homeobox proteins, its behavior could be completely different from that of the previously described variationless HOXB9. Because none of the previous studies on HOXB9 have considered the presence of HOXB9v, further research analyzing the two transcripts individually is warranted to re-evaluate the true role of HOXB9 in cancer.


2020 ◽  
Vol Volume 13 ◽  
pp. 6593-6601
Author(s):  
Xiaoyan Li ◽  
Liu Tian ◽  
Lina Zhang ◽  
Baojin Xu ◽  
Yong Zhang ◽  
...  

2017 ◽  
Vol 37 (3) ◽  
pp. 1707-1715 ◽  
Author(s):  
Shuo Cai ◽  
Ping-Hui Sun ◽  
Jeyna Resaul ◽  
Lei Shi ◽  
Aihua Jiang ◽  
...  

2004 ◽  
Vol 91 (5) ◽  
pp. 959-965 ◽  
Author(s):  
Y Sagara ◽  
K Mimori ◽  
K Yoshinaga ◽  
F Tanaka ◽  
K Nishida ◽  
...  

1995 ◽  
Vol 2 (4) ◽  
pp. 281-292
Author(s):  
A H Bootsma ◽  
C H J van Eijck ◽  
L J Hofland ◽  
S W J Lamberts

Author(s):  
Gaynor Davies ◽  
Khaled Rmali ◽  
Gareth Watkins ◽  
Robert Mansel ◽  
Malcolm Mason ◽  
...  

2010 ◽  
Vol 8 (3) ◽  
pp. 116
Author(s):  
B.K. Lee ◽  
S.H. Jung ◽  
H.J. Youn ◽  
J.H. Yoon ◽  
M.H. Park

2014 ◽  
Vol 71 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Lv Li ◽  
Qimin Wang ◽  
Xiupeng Lv ◽  
Lin Sha ◽  
Huamin Qin ◽  
...  

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