scholarly journals Beneficial effects of intramyocardial mesenchymal stem cells and VEGF 165 plasmid injection in rats with furazolidone induced dilated cardiomyopathy

2015 ◽  
Vol 19 (8) ◽  
pp. 1868-1876 ◽  
Author(s):  
Qin Yu ◽  
Weiyi Fang ◽  
Ning Zhu ◽  
Xiaoqun Zheng ◽  
Rongmei Na ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dilated Cardiomyopathy ◽  
Beneficial Effects ◽  
Plasmid Injection

scholarly journals Adipose-derived mesenchymal stem cells preserve cardiac function via ANT-1 in dilated cardiomyopathy hamster model

2021 ◽  
Vol 18 ◽  
pp. 182-190
Author(s):  
Daisuke Mori ◽  
Shigeru Miyagawa ◽  
Takashi Kido ◽  
Hiroki Hata ◽  
Takayoshi Ueno ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cardiac Function ◽  
Dilated Cardiomyopathy ◽  
Hamster Model

From mesenchymal stem cells and stromal cells - from bench to bedside

2019 ◽  
Vol 1 (1) ◽  
pp. 36-39
Author(s):  
Bernd Giebel ◽  
Verena Börger ◽  
Mario Gimona ◽  
Eva Rohde
Keyword(s):  
Stem Cells ◽  
Clinical Trials ◽  
Mesenchymal Stem Cells ◽  
Stromal Cells ◽  
Therapeutic Agent ◽  
Therapeutic Potential ◽  
Therapeutic Effects ◽  
Cell Replacement ◽  
Beneficial Effects ◽  
Promising Tool

Human mesenchymal stem/stromal cells (MSCs) represent a promising tool in regenerative medicine. Until now, almost one thousand NIH-registered clinical trials investigated their immunomodulatory and pro-regenerative therapeutic potential in various diseases. Despite controversial reports regarding the efficacy of MSC-treatments, MSCs appear to exert their beneficial effects in a paracrine manner rather than by cell replacement. In this context, extracellular vesicles (EVs), such as exosomes and microvesicles, seem to induce the MSCs’ therapeutic effects. Here, we briefly illustrate the potential of MSC-EVs as therapeutic agent of the future.

scholarly journals Cytoprotective roles of epigallocatechin gallate and resveratrol on staurosporine-treated mesenchymal stem cells in in vitro culture

2021 ◽  
Vol 67 (3) ◽  
pp. 45-52
Author(s):  
Arkadiusz Burczak ◽  
Magdalena Kosiedowska ◽  
Paulina Borkowska ◽  
Jan Kowalski
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Negative Impact ◽  
Colorimetric Assay ◽  
Antioxidant Properties ◽  
Circulatory System ◽  
Epigallocatechin Gallate ◽  
Regenerative Capacity ◽  
Beneficial Effects

Summary Introduction: There are many scientific reports on the beneficial effects of epigallocatechin gallate and resveratrol on the human body, e.g. antioxidant properties, a protective effect on the circulatory system and reduction of inflammation. Objective: The aim of the study was to evaluate the effect of these substances on the survival of mesenchymal stem cells (MSC) in the presence of the pro-apoptotic factor staurosporine. Methods: Cell viability WST-1 colorimetric assay. Results: It was confirmed that both 25 µM/ml and 50 µM/ml of epigallocatechin and 50 µM/ml of resveratrol statistically significantly increased the MSC survival rate. Conclusion: An excess supply of epigallocatechin gallate (50 µM/ml and higher) has a cytotoxic effect on MSC, which may have a negative impact on the body’s auto-regenerative capacity. Under toxic and stressful conditions, resveratrol and epigallocatechin gallate perform cytoprotective functions, thereby reducing the negative impact of toxic environmental conditions on the mesenchymal stem cells.

scholarly journals Transplantation of Mesenchymal Stem Cells Improves Cardiac Function in a Rat Model of Dilated Cardiomyopathy

Circulation ◽  
2005 ◽  
Vol 112 (8) ◽  
pp. 1128-1135 ◽  
Author(s):  
Noritoshi Nagaya ◽  
Kenji Kangawa ◽  
Takefumi Itoh ◽  
Takashi Iwase ◽  
Shinsuke Murakami ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cardiac Function ◽  
Dilated Cardiomyopathy ◽  
Rat Model
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