scholarly journals Dehydrozingerone exerts beneficial metabolic effects in high‐fat diet‐induced obese mice via AMPK activation in skeletal muscle

2015 ◽  
Vol 19 (3) ◽  
pp. 620-629 ◽  
Author(s):  
Su Jin Kim ◽  
Hong Min Kim ◽  
Eun Soo Lee ◽  
Nami Kim ◽  
Jung Ok Lee ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
High Fat Diet ◽  
Metabolic Effects ◽  
Ampk Activation ◽  
Obese Mice ◽  
High Fat

scholarly journals Selenoprotein W deficiency does not affect oxidative stress and insulin sensitivity in the skeletal muscle of high-fat diet-fed obese mice

2019 ◽  
Vol 317 (6) ◽  
pp. C1172-C1182 ◽  
Author(s):  
Min-Gyeong Shin ◽  
Hye-Na Cha ◽  
Soyoung Park ◽  
Yong-Woon Kim ◽  
Jong-Yeon Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
High Fat Diet ◽  
Control Diet ◽  
In Vivo Studies ◽  
Selenoprotein W ◽  
Obese Mice ◽  
High Fat

Selenoprotein W (SelW) is a selenium-containing protein with a redox motif found abundantly in the skeletal muscle of rodents. Previous in vitro studies suggest that SelW plays an antioxidant role; however, relatively few in vivo studies have addressed the antioxidant role of SelW. Since oxidative stress is a causative factor for the development of insulin resistance in obese subjects, we hypothesized that if SelW plays a role as an antioxidant, SelW deficiency could aggravate the oxidative stress and insulin resistance caused by a high-fat diet. SelW deficiency did not affect insulin sensitivity and H2O2 levels in the skeletal muscle of control diet-fed mice. SelW levels in the skeletal muscle were decreased by high-fat diet feeding for 12 wk. High-fat diet induced obesity and insulin resistance and increased the levels of H2O2 and oxidative stress makers, which were not affected by SelW deficiency. High-fat diet feeding increased the expression of antioxidant enzymes; however, SelW deficiency did not affect the expression levels of antioxidants. These results suggest that SelW does not play a protective role against oxidative stress and insulin resistance in the skeletal muscle of high-fat diet-fed obese mice.

Metabolic effects of the iodothyronine functional analogue TRC150094 on the liver and skeletal muscle of high-fat diet fed overweight rats: an integrated proteomic study

2012 ◽  
Vol 8 (7) ◽  
pp. 1987 ◽  
Author(s):  
Elena Silvestri ◽  
Daniela Glinni ◽  
Federica Cioffi ◽  
Maria Moreno ◽  
Assunta Lombardi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
High Fat Diet ◽  
Metabolic Effects ◽  
High Fat ◽  
Proteomic Study

scholarly journals CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction

2013 ◽  
Vol 305 (5) ◽  
pp. R522-R533 ◽  
Author(s):  
Jonathan M. Peterson ◽  
Zhikui Wei ◽  
Marcus M. Seldin ◽  
Mardi S. Byerly ◽  
Susan Aja ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Transgenic Mice ◽  
High Fat Diet ◽  
Fat Oxidation ◽  
Acid Oxidation ◽  
Ampk Activation ◽  
High Fat ◽  
Diet Induced Obesity

CTRP9 is a secreted multimeric protein of the C1q family and the closest paralog of the insulin-sensitizing adipokine, adiponectin. The metabolic function of this adipose tissue-derived plasma protein remains largely unknown. Here, we show that the circulating levels of CTRP9 are downregulated in diet-induced obese mice and upregulated upon refeeding. Overexpressing CTRP9 resulted in lean mice that dramatically resisted weight gain induced by a high-fat diet, largely through decreased food intake and increased basal metabolism. Enhanced fat oxidation in CTRP9 transgenic mice resulted from increases in skeletal muscle mitochondrial content, expression of enzymes involved in fatty acid oxidation (LCAD and MCAD), and chronic AMPK activation. Hepatic and skeletal muscle triglyceride levels were substantially decreased in transgenic mice. Consequently, CTRP9 transgenic mice had a greatly improved metabolic profile with markedly reduced fasting insulin and glucose levels. The high-fat diet-induced obesity, insulin resistance, and hepatic steatosis observed in wild-type mice were prevented in transgenic mice. Consistent with the in vivo data, recombinant protein significantly enhanced fat oxidation in L6 myotubes via AMPK activation and reduced lipid accumulation in H4IIE hepatocytes. Collectively, these data establish CTRP9 as a novel metabolic regulator and a new component of the metabolic network that links adipose tissue to lipid metabolism in skeletal muscle and liver.

scholarly journals Coffee intake mitigated inflammation and obesity-induced insulin resistance in skeletal muscle of high-fat diet-induced obese mice

2014 ◽  
Vol 9 (3) ◽  
Author(s):  
Huijuan Jia ◽  
Wanping Aw ◽  
Kenji Egashira ◽  
Shoko Takahashi ◽  
Shinya Aoyama ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
High Fat Diet ◽  
Obese Mice ◽  
High Fat ◽  
Coffee Intake

scholarly journals Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat Diet in Mice

2020 ◽  
Vol 21 (20) ◽  
pp. 7582
Author(s):  
Jonatan Dassonvalle ◽  
Francisco Díaz-Castro ◽  
Camila Donoso-Barraza ◽  
Carlos Sepúlveda ◽  
Francisco Pino-de la Fuente ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Energy Balance ◽  
Aerobic Exercise ◽  
High Fat Diet ◽  
Aerobic Exercise Training ◽  
Metabolic Effects ◽  
Obese Mice ◽  
High Fat ◽  
Epididymal Fat ◽  
Glucocorticoid Response

Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is associated with the development of obesity and metabolic syndrome. However, it is not understood if obesity alters the tissue glucocorticoid receptor (GR) response, and moreover whether a moderate aerobic exercise prevents the alteration in GR response induced by obesity. Methods: To evaluate the GR response in obese mice, we fed C57BL6J mice with a high-fat diet (HFD) for 12 weeks. Before mice were sacrificed, we injected them with dexamethasone. To assess the exercise role in GR response, we fed mice an HFD and subjected them to moderate aerobic exercise three times a week. Results: We found that mice fed a high-fat diet for 12 weeks developed hepatic GC hypersensitivity without changes in the gastrocnemius or epididymal fat GR response. Therefore, moderate aerobic exercise improved glucose tolerance, increased the corticosterone plasma levels, and prevented hepatic GR hypersensitivity with an increase in epididymal fat GR response. Conclusion: Collectively, our results suggest that mice with HFD-induced obesity develop hepatic GR sensitivity, which could enhance the metabolic effects of HFD in the liver. Moreover, exercise was found to be a feasible non-pharmacological strategy to prevent the deregulation of GR response in obesity.

The metabolic regulation of Fuzhuan brick tea in the high-fat diet-induced obese mice and the potential contribution of gut microbiota

2021 ◽  
Author(s):  
Dongming Liu ◽  
Jianhui Wang ◽  
Hongliang Zeng ◽  
Fang Zhou ◽  
Bei-Bei Wen ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Regulation ◽  
Metabolic Effects ◽  
Potential Contribution ◽  
Obese Mice ◽  
High Fat

This study investigated the metabolic effects of Fuzhuan brick tea (FBT) in high-fat diet (HFD)-induced obese mice and the potential contribution of gut microbiota. The results showed that FBT ameliorated...

scholarly journals Effects of treadmill exercise on skeletal muscle mTOR signaling pathway in high-fat diet-induced obese mice

2016 ◽  
Vol 28 (4) ◽  
pp. 1260-1265 ◽  
Author(s):  
Jin Hee Woo ◽  
Ki Ok Shin ◽  
Yul Hyo Lee ◽  
Ki Soeng Jang ◽  
Ju Yong Bae ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Signaling Pathway ◽  
High Fat Diet ◽  
Treadmill Exercise ◽  
Mtor Signaling ◽  
Obese Mice ◽  
Mtor Signaling Pathway ◽  
High Fat

Arctigenin Inhibits Adipogenesis by Inducing AMPK Activation and Reduces Weight Gain in High-Fat Diet-Induced Obese Mice

2016 ◽  
Vol 117 (9) ◽  
pp. 2067-2077 ◽  
Author(s):  
Yo-Han Han ◽  
Ji-Ye Kee ◽  
Jinbong Park ◽  
Hye-Lin Kim ◽  
Mi-Young Jeong ◽  
...  
Keyword(s):  
Weight Gain ◽  
High Fat Diet ◽  
Ampk Activation ◽  
Obese Mice ◽  
High Fat

scholarly journals Effects of different intensities of physical exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice

2014 ◽  
Vol 12 (1) ◽  
pp. 82-89 ◽  
Author(s):  
Rodolfo Marinho ◽  
Leandro Pereira de Moura ◽  
Bárbara de Almeida Rodrigues ◽  
Luciana Santos Souza Pauli ◽  
Adelino Sanchez Ramos da Silva ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Protein Kinase ◽  
High Fat Diet ◽  
Protein Kinase B ◽  
Whole Body ◽  
Control Group ◽  
Standard Diet ◽  
Obese Mice ◽  
High Fat

Objective : To investigate the effects of different intensities of acute exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice. Methods : Swiss mice were randomly divided into four groups, and fed either a standard diet (control group) or high fat diet (obese sedentary group and obese exercise group 1 and 2) for 12 weeks. Two different exercise protocols were used: swimming for 1 hour with or without an overload of 5% body weight. The insulin tolerance test was performed to estimate whole-body sensitivity. Western blot technique was used to determine protein levels of protein kinase B/Akt and phosphorylation by protein Kinase B/Akt in mice skeletal muscle. Results : A single bout of exercise inhibited the high fat diet-induced insulin resistance. There was increase in phosphorylation by protein kinase B/Akt serine, improve in insulin signaling and reduce of fasting glucose in mice that swam for 1 hour without overload and mice that swan for 1 hour with overload of 5%. However, no significant differences were seen between exercised groups. Conclusion : Regardless of intensity, aerobic exercise was able to improve insulin sensitivity and phosphorylation by protein kinase B/Ak, and proved to be a good form of treatment and prevention of type 2 diabetes.

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