scholarly journals A two‐sample Mendelian randomization analysis of heart rate variability and cerebral small vessel disease

2021 ◽  
Author(s):  
Danyang Tian ◽  
Linjing Zhang ◽  
Zhenhuang Zhuang ◽  
Tao Huang ◽  
Dongsheng Fan
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Mendelian Randomization ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Effect of Heart Rate Variability on the Association Between the Apnea-Hypopnea Index and Cerebral Small Vessel Disease

Stroke ◽  
2019 ◽  
Vol 50 (9) ◽  
pp. 2486-2491 ◽  
Author(s):  
Oscar H. Del Brutto ◽  
Robertino M. Mera ◽  
Aldo F. Costa ◽  
Pablo R. Castillo
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Apnea Hypopnea Index ◽  
Vessel Disease

scholarly journals Validation of external and internal exposome of the findings associated to cerebral small vessel disease: A Mendelian randomization study

2022 ◽  
pp. 0271678X2210742
Author(s):  
Xue-Qing Zhang ◽  
Yu-Xiang Yang ◽  
Can Zhang ◽  
Xin-Yi Leng ◽  
Shi-Dong Chen ◽  
...  
Keyword(s):  
Mendelian Randomization ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Fat Free Mass ◽  
Small Vessel ◽  
Sensitivity Analyses ◽  
Vessel Disease ◽  
Increased Risk ◽  
Lobar Hemorrhage ◽  
Health Rating

The exposome characterizes all environmental exposures and their impact on a disease. To determine the causally-associated components of the exposome for cerebral small vessel disease (CSVD), we performed mendelian randomization analysis of 5365 exposures on six clinical and subclinical CSVD measures. We found statistically significant evidence (FDR-corrected P < 0.05) that hypertension, high cholesterol, longer television-watching time, lower educational qualifications, younger age of first sexual intercourse, smoking, reduced pulmonary function, higher subjective overall health rating, and frequent tiredness were associated with increased risk of intracerebral hemorrhage or small vessel stroke. Adiposity, diabetes, frequent alcoholic drinks, higher white blood cell count and neutrophil count were significantly associated with higher risk of non-lobar hemorrhage or small vessel stroke, but not lobar hemorrhage. Hypertension, higher arm or leg fat-free mass and higher sitting height were significantly associated with higher white matter hyperintensities. The results were robust to sensitivity analyses and showed no evidence of horizontal pleiotropy. We also identified 41 exposures suggestively associated (uncorrected P < 0.05) with multiple CSVD measures as the “the CSVD exposome”. This exposome-wide association study provides insight into CSVD development and prevention.

scholarly journals Decreased Nocturnal Heart Rate Variability and Potentially Related Brain Regions In Arteriosclerotic Cerebral Small Vessel Disease

2021 ◽  
Author(s):  
Miaoyi Zhang ◽  
Huan Yu ◽  
Weijun Tang ◽  
Ding Ding ◽  
Jie Tang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Sleep Disordered Breathing ◽  
Small Vessel Disease ◽  
Brain Regions ◽  
Cerebral Small Vessel Disease ◽  
Sleep Period ◽  
Vessel Disease ◽  
Cerebrovascular Risk

Abstract Background To assess heart rate variability(HRV) among patients with arteriosclerotic cerebral small vessel disease (CSVD) by comparing with control subjects, and to determine whether HRV parameters were related to structural alterations in brain regions involved in autonomic regulation among CSVD patients. MethodsWe consecutively recruited subjects aged between 50 and 80 years who visited the Sleep Center of Huashan Hospital from September 1, 2018 to August 31, 2019. Brain magnetic resonance imaging(MRI) was scanned before enrollment. 63 patients were assigned to the arteriosclerotic CSVD group and 46 to the control group. Polysomnography and synchronous analyses of HRV were performed. Multivariable binary logistic regression was used to identify the relationship between HRV parameters and CSVD. A number of 24 CSVD patients and 21 control participants further underwent three-dimensional brain volume scan, and the voxel based morphometry (VBM) analysis was used to identify gray matter atrophy.ResultsLower standard deviation of normal-to-normal intervals(SDNN, OR=0.943, 95% CI 0.903 to 0.985, P=0.009) and higher ratio of low to high frequency power (LF/HF, OR=4.372, 95% CI 1.033 to 18.508, P=0.045) during the sleep period were associated with CSVD, independent of traditional cerebrovascular risk factors and sleep disordered breathing. Based on VBM results, SDNN during the awake time (b=0.544, 95% CI 0.211 to 0.877, P=0.001) and the sleep period(b=0.532, 95% CI 0.202 to 0.862, P=0.001) were both positively related with gray matter thickness within the right inferior frontal gyrus only among CSVD patients.ConclusionsDecreased nocturnal HRV may be associated with arteriosclerotic CSVD independent of traditional cerebrovascular risk factors and sleep disordered breathing. The structural atrophy of some brain regions associated with cardiac autonomic regulation sheds light on the potential relationship.Trial registration Trial registration number: ChiCTR1800017902.Date of registration: 2018-08-20

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