scholarly journals Different effects of morning and nocturnal hypertension on target organ damage in chronic kidney disease

2021 ◽  
Author(s):  
Xue Li ◽  
Jianting Ke ◽  
Xiaoqiu Chen ◽  
Mengmeng Yin ◽  
Tanqi Lou ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Nocturnal Hypertension

scholarly journals Nocturnal Hypertension Correlates Better With Target Organ Damage in Patients With Chronic Kidney Disease than a Nondipping Pattern

2015 ◽  
Vol 17 (10) ◽  
pp. 792-801 ◽  
Author(s):  
Cheng Wang ◽  
Wen-Jie Deng ◽  
Wen-Yu Gong ◽  
Jun Zhang ◽  
Qun-Zi Zhang ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Nocturnal Hypertension

scholarly journals The Association of Morning Hypertension With Target Organ Damage in Patients With Chronic Kidney Disease and Hypertension

2021 ◽  
Vol 8 ◽  
Author(s):  
Xiang Liu ◽  
Fangming Li ◽  
Ting Zhang ◽  
Zhiyao Zheng ◽  
Huan Zhou ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Left Ventricular ◽  
Target Organ ◽  
Strongly Correlated ◽  
Nocturnal Hypertension ◽  
Morning Hypertension

Objectives: To determine the association between morning hypertension and target organ damage (TOD) in patients with chronic kidney disease (CKD) and hypertension.Methods: In this cross-sectional study, 447 patients with CKD and hypertension from two centers were enrolled. Ambulatory blood pressure monitoring was conducted in all patients. Linear regression and logistic regression analysis were used to determine the association between morning hypertension and TOD in patients with CKD and hypertension, including assessments of estimated glomerular filtration rate (eGFR), left ventricular mass index (LVMI), urine protein/creatinine ratio (UPCR), and left ventricular hypertrophy (LVH).Results: Overall, 194 (43.4%) participants had morning hypertension. Morning hypertension was strongly correlated with LVH [odds ratio (OR), 2.14; 95% confidence interval (CI), 1.3–3.51; p < 0.01], lower level of eGFR (β = −0.51; 95%CI, −0.95–−0.08; p < 0.05), higher LVMI (β = 0.06; 95%CI, 0.04–0.08, p < 0.001), and UPCR (β = 0.22; 95%CI, 0.06–0.38, p < 0.01), independent of nocturnal hypertension and elevated morning blood pressure surge. As a continuous variable, both morning systolic blood pressure (SBP) and diastolic blood pressure (DBP) were found to be associated with LVH and higher level of UPCR and LVMI (p < 0.05), whereas only morning SBP was negatively correlated with eGFR (p < 0.01).Conclusion: Morning hypertension was strongly correlated with cardiac damage and impaired kidney function in CKD patients with hypertension, independent of nocturnal hypertension and morning surge in blood pressure. Morning hypertension in CKD patients warrants further attention.

scholarly journals MP12624-HOUR PULSE PRESSURE AND NOCTURNAL HYPERTENSION CORRELATE WITH TARGET ORGAN DAMAGE IN CHRONIC KIDNEY DISEASE PATIENTS

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii473-iii474
Author(s):  
Dominika Klimczak ◽  
Tomasz Pilecki ◽  
Dorota Zochowska ◽  
Agnieszka Wirkowska ◽  
Marek Kuch ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Pulse Pressure ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Nocturnal Hypertension

[PS 08-42] ASSOCIATION OF CENTRAL BLOOD PRESSURE WITH MARKERS FOR TARGET ORGAN DAMAGE IN CHRONIC KIDNEY DISEASE PATIENTS

2016 ◽  
Vol 34 (Supplement 1) ◽  
pp. e304
Author(s):  
Youn Kyung Kee ◽  
Chan-Yun Yoon ◽  
Seohyun Park ◽  
Jung Tak Park ◽  
Seung Hyeok Han ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Central Blood Pressure

scholarly journals Circulating let-7g-5p and miR-191-5p Are Independent Predictors of Chronic Kidney Disease in Hypertensive Patients

2020 ◽  
Vol 33 (6) ◽  
pp. 505-513 ◽  
Author(s):  
Olga Berillo ◽  
Ku-Geng Huo ◽  
Júlio C Fraulob-Aquino ◽  
Chantal Richer ◽  
Marie Briet ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Target Organ Damage ◽  
Kidney Injury ◽  
Organ Damage ◽  
Target Organ ◽  
Small Rna Sequencing ◽  
Therapeutic Implications ◽  
The Metabolic Syndrome ◽  
Circulating Rna

Abstract BACKGROUND Hypertension (HTN) is associated with target organ damage such as cardiac, vascular, and kidney injury. Several studies have investigated circulating microRNAs (miRNAs) as biomarkers of cardiovascular disease, but few have examined them as biomarker of target organ damage in HTN. We aimed to identify circulating miRNAs that could serve as biomarkers of HTN-induced target organ damage using an unbiased approach. METHODS AND RESULTS Fifteen normotensive subjects, 16 patients with HTN, 15 with HTN associated with other features of the metabolic syndrome (MetS), and 16 with HTN or chronic kidney disease (CKD) were studied. Circulating RNA extracted from platelet-poor plasma was used for small RNA sequencing. Differentially expressed (DE) genes were identified with a threshold of false discovery rate <0.1. DE miRNAs were identified uniquely associated with HTN, MetS, or CKD. However, only 2 downregulated DE miRNAs (let-7g-5p and miR-191-5p) could be validated by reverse transcription-quantitative PCR. Let-7g-5p was associated with large vessel stiffening, miR-191-5p with MetS, and both miRNAs with estimated glomerular filtration rate (eGFR) and neutrophil and lymphocyte fraction or number and neutrophil-to-lymphocyte ratio. Using the whole population, stepwise multiple linear regression generated a model showing that let-7g-5p, miR-191-5p, and urinary albumin/creatinine ratio predicted eGFR with an adjusted R2 of 0.46 (P = 8.5e−7). CONCLUSIONS We identified decreased circulating let-7g-5p and miR-191-5p as independent biomarkers of CKD among patients with HTN, which could have pathophysiological and therapeutic implications.

Changes of blood pressure patterns and target organ damage in patients with chronic kidney disease

2017 ◽  
Vol 35 (3) ◽  
pp. 593-601 ◽  
Author(s):  
Ran-Hui Cha ◽  
Hajeong Lee ◽  
Jung Pyo Lee ◽  
Eunjeong Kang ◽  
Young Rim Song ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Blood Pressure Patterns

OS 19-06 CHANGE OF BLOOD PRESSURE PATTERN AND TARGET ORGAN DAMAGE IN PATIENTS WITH CHRONIC KIDNEY DISEASE

2016 ◽  
Vol 34 (Supplement 1) ◽  
pp. e230 ◽  
Author(s):  
Ran-hui Cha ◽  
Hajeong Lee ◽  
Jung Pyo Lee ◽  
Chun Soo Lim ◽  
Yon Su Kim ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Pressure Pattern
Sign in / Sign up

Export Citation Format

Share Document