scholarly journals Association of impaired arterial wall properties with the presence of coronary artery disease in patients with abdominal aortic aneurysms

2020 ◽  
Vol 22 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Pinelopi Rafouli‐Stergiou ◽  
Ignatios Ikonomidis ◽  
Niki Katsiki ◽  
Nikolaos P. E. Kadoglou ◽  
Stefanos Vlachos ◽  
...  
2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Hassan Al-Thani ◽  
Ayman El-Menyar

We aimed to evaluate the frequency, clinical profiles and outcomes of abdominal aortic aneurysms (AAA), and their association with coronary artery disease (CAD) in a small country with high cardiovascular burden. Methods. Data were collected for all adult patients who underwent abdominal computed tomography scans at Hamad General Hospital in Qatar between 2004 and 2008. Results. Out of 13,115 screened patients for various reasons, 61 patients (0.5%) had abdominal aneurysms. The majority of AAA patients were male (82%) with a mean age of 67 ± 12 years. The incidence of AAA substantially increased with age reaching up to 5% in patients >80 yrs. Hypertension was the most prevalent risk factor for AAA followed by smoking, dyslipidemia, renal impairment, and diabetes mellitus. CAD and peripheral arterial disease (PAD) were observed in 36% and 13% of AAA patients, respectively. There were no significant correlations between CAD or PAD and site and size of AAA. Conclusion. This is the largest study in our region that describes the epidemiology of AAA with concomitant CAD. As the mortality rate is quite high in this high risk population, routine screening for AAA in CAD patients and vice versa needs further studies for proper risk stratification.


1993 ◽  
Vol 18 (3) ◽  
pp. 349-357 ◽  
Author(s):  
William D. Suggs ◽  
Robert B. Smith ◽  
William S. Weintraub ◽  
Thomas F. Dodson ◽  
Atef A. Salam ◽  
...  

EJVES Extra ◽  
2008 ◽  
Vol 15 (5) ◽  
pp. 37-38 ◽  
Author(s):  
J.-A. Wang ◽  
X.-F. Chen ◽  
W.-F. Yu ◽  
H. Chen ◽  
X.-M. Liu ◽  
...  

1993 ◽  
Vol 18 (3) ◽  
pp. 349-357 ◽  
Author(s):  
Robert B. Smith ◽  
William D. Suggs ◽  
Robert B. Smith ◽  
William S. Weintraub ◽  
Thomas F. Dodson ◽  
...  

2016 ◽  
Vol 105 (4) ◽  
pp. 235-240 ◽  
Author(s):  
V. Vänni ◽  
T. Hakala ◽  
J. Mustonen ◽  
J. Turtiainen ◽  
T. T. Rissanen ◽  
...  

Background and Aims: According to the heterogeneous results of previous studies, the prevalence of abdominal aortic aneurysm seems high among men with coronary artery disease. The associating risk factors for abdominal aortic aneurysm in this population require clarification. Our objective was to assess the prevalence of non-diagnosed abdominal aortic aneurysms in men with angiographically verified coronary artery disease and to document the associated co-morbidities and risk factors. Material and Methods: Altogether, 407 men with coronary artery disease were screened after invasive coronary angiography in two series at independent centers. Risk factor data were recorded and analyzed. Results and Conclusion: The mean age of the study cohort was 70.0 years (standard deviation: 11.0). The prevalence of previously undiagnosed abdominal aortic aneurysms in the whole screened population of 407 men was 6.1% (n = 25/407). In a multivariate analysis of the whole study population, the only significant risk factors for abdominal aortic aneurysm were age (odds ratio: 1.04, 95% confidence interval: 1.00–1.09) and history of smoking (odds ratio: 3.13, 95% confidence interval: 1.26–7.80). Non-smokers with abdominal aortic aneurysm were significantly older than smokers (mean age: 80.7 (standard deviation: 8.0) vs 68.0 (standard deviation: 11.1), p = 0.003), and age was a significant risk factor only among non-smokers (p = 0.011; p = 0.018 for interaction). Among smokers, the prevalence of abdominal aortic aneurysm was 8.8%, and 72% (n = 18/25) of all diagnosed abdominal aortic aneurysm patients were smokers. Prevalence of undiagnosed abdominal aortic aneurysms among patients with coronary artery disease is high, and history of smoking is the most significant risk factor for abdominal aortic aneurysm. Effectiveness of selective screening of abdominal aortic aneurysm in male patients with coronary artery disease warrants further studies.


2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
I Ikonomidis ◽  
P Rafouli-Stergiou ◽  
N Katsiki ◽  
N Kadoglou ◽  
S Vlachos ◽  
...  

Abstract Introduction Pulse wave velocity (PWV) is a valid, clinically feasible marker of arterial stiffening, and a strong predictor of outcomes. In patients with abdominal aortic aneurysms (AAA) alterations in arterial wall composition and inflammation were proposed as possible contributors to increased arterial stiffness. Purpose The present study aimed to compare aortic elastic properties in patients with abdominal aortic aneurysms (AAA), with or without coronary artery disease (CAD), as well as healthy individuals. Methods A total of 130 patients with AAA, eligible for interventional repair, and 30 healthy individuals, comprising the control group (HC), were evaluated. Study groups did not differ in anthropometrical characteristics and CV risk factors. Presence of CAD was identified by coronary angiography. Aortic PWV (aPWV) was measured using the Arteriograph method. Results aPWV was found considerably higher in AAA patients compared to HC group (11.5±2.9 vs. 7.3±1.6 m/s, p<0.001), after adjustment for age, sex and mean arterial pressure (MAP). Interestingly, among patients with AAA, those with concomitant CAD (n=41) had higher aPWV than those without CAD (12.5±2.9 vs. 11.0±3.0 m/s, p=0.03), after adjustment for age, sex and MAP. In receiver-operator-curve (ROC) analysis, the area under the curve (AUC) of aPWV for the prediction of CAD presence in the AAA study group was 0.72 [95% confidence interval (CI): 0.55–0.84, p=0.03]. According to this, the best cut-off was a value of aPWV above 12.8 m/s (78% sensitivity and 73% specificity). This cut-off was identified as a significant predictor of CAD presence in the AAA study population according to univariate logistic regression analysis (OR=2.51, 95% CI: 1.79–5.19, p=0.02). After adjustment for age, sex, dyslipidemia, smoking and MAP in multivariate logistic regression analysis, the cut-off aPWV level remained independently associated with the presence of CAD (OR=1.64, 95% CI: 1.19–4.08, p=0.03). Conclusion The co-existence of CAD and AAA is characterized by a greater arterial stiffness. This finding supports a role of measuring arterial stiffness markers when evaluating AAA patients' cardiovascular risk and selecting endovascular stents with more favorable elastic properties. Further studies are needed to explore whether aPWV values could be used to as a screening tool to detect CAD or to guide treatment in AAA patients. Funding Acknowledgement Type of funding source: None


Kardiologiia ◽  
2014 ◽  
Vol 3_2014 ◽  
pp. 37-41 ◽  
Author(s):  
E.R. Charchan Charchan ◽  
A.B. Stepanenko Stepanenko ◽  
A.P. Gens Gens ◽  
S.A. Abugov Abugov ◽  
R.S. Polyakov Polyakov ◽  
...  

1990 ◽  
Vol 212 (4) ◽  
pp. 415-423 ◽  
Author(s):  
MICHAEL A. GOLDEN ◽  
ANTHONY D. WHITTEMORE ◽  
MAGRUDER C. DONALDSON ◽  
JOHN A. MANNICK

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