scholarly journals The association of obstructive sleep apnea and left ventricular hypertrophy in obese and overweight children with history of elevated blood pressure

2019 ◽  
Vol 21 (7) ◽  
pp. 984-990 ◽  
Author(s):  
Colleen E. Hanlon ◽  
Edem Binka ◽  
Jeffrey S. Garofano ◽  
Laura M. Sterni ◽  
Tammy M. Brady
Keyword(s):  
Blood Pressure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Elevated Blood ◽  
Overweight Children ◽  
Obstructive Sleep ◽  
History Of

scholarly journals The Effects of Eplerenone on the Circadian Blood Pressure Pattern and Left Ventricular Hypertrophy in Patients with Obstructive Sleep Apnea and Resistant Hypertension—A Randomized, Controlled Trial

2019 ◽  
Vol 8 (10) ◽  
pp. 1671 ◽  
Author(s):  
Beata Krasińska ◽  
Szczepan Cofta ◽  
Ludwina Szczepaniak-Chicheł ◽  
Piotr Rzymski ◽  
Tomasz Trafas ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Treatment Group ◽  
Left Ventricular Hypertrophy ◽  
Antihypertensive Therapy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Night Time ◽  
Obstructive Sleep

The obstructive sleep apnea (OSA) is highly associated with various significant cardiovascular outcomes such as resistant hypertension (RAH). Despite this, as of now the relationship between high night-time blood pressure (BP) and left ventricular hypertrophy (LVH) in patients with OSA and RAH is not fully understood. The aim of this study was to assess the influence of the addition of eplerenone to a standard antihypertensive therapy on parameters of 24-h ambulatory blood pressure measurement (ABPM) as well as on the results of echocardiography and polysomnography in patients with OSA and RAH. The patients were randomly assigned to one of the two study groups: the treatment group, receiving 50 mg/d eplerenone orally for 6 months (n = 51) and the control group, remaining on their standard antihypertensive therapy (n = 51). After that period, a significant reduction in the night-time BP parameters in the treatment group including an increased night blood pressure fall from 4.6 to 8.9% was noted. Additionally, the number of non-dipper patients was reduced by 45.1%. The treatment group also revealed a decrease in left ventricular hypertrophy and in the apnea–hypopnea index (AHI) with a positive correlation being observed between these two parameters. This study is the first to report the improvement of the circadian BP profile and the improvement of the left ventricle geometry in patients with OSA and RAH following the addition of selective mineralocorticoid receptor antagonists to antihypertensive therapy.

PREVALENCE OF LEFT VENTRICULAR HYPERTROPHY IN PERSONS WITH AND WITHOUT OBSTRUCTIVE SLEEP APNEA

CHEST Journal ◽  
2006 ◽  
Vol 130 (4) ◽  
pp. 93S
Author(s):  
Rishi Sukhija ◽  
Wilbert S. Aronow ◽  
Rasham Sandhu ◽  
Priyanka Kakar ◽  
George P. Maguire ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Obstructive Sleep
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