scholarly journals A patient-specific approach to assessing blood pressure management in patients with hypertension and coronary artery disease

2018 ◽  
Vol 20 (2) ◽  
pp. 233-239
Author(s):  
Jeffrey Yim ◽  
Simon W. Rabkin
Keyword(s):  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Patient Specific ◽  
Pressure Management ◽  
Specific Approach ◽  
Blood Pressure Management ◽  
Artery Disease

scholarly journals Heterogeneous Effects of Association Between Blood Pressure Loci and Coronary Artery Disease in East Asian Individuals

2015 ◽  
Vol 79 (4) ◽  
pp. 830-838 ◽  
Author(s):  
Fumihiko Takeuchi ◽  
Masato Isono ◽  
Ken Yamamoto ◽  
Mitsuhiro Yokota ◽  
Koichi Akiyama ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
East Asian ◽  
Heterogeneous Effects ◽  
Artery Disease

scholarly journals Increased response of diastolic blood pressure to exercise in patients with coronary artery disease: an index of latent ventricular dysfunction?

Heart ◽  
1993 ◽  
Vol 69 (6) ◽  
pp. 507-511 ◽  
Author(s):  
I A Paraskevaidis ◽  
D T Kremastinos ◽  
A S Kassimatis ◽  
G K Karavolias ◽  
G D Kordosis ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Diastolic Blood Pressure ◽  
Ventricular Dysfunction ◽  
Artery Disease

scholarly journals Morning and Evening Home Blood Pressure and Risks of Incident Stroke and Coronary Artery Disease in the Japanese General Practice Population

Hypertension ◽  
2016 ◽  
Vol 68 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Satoshi Hoshide ◽  
Yuichiro Yano ◽  
Hajime Haimoto ◽  
Kayo Yamagiwa ◽  
Kiyoshi Uchiba ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Coronary Artery Disease ◽  
General Practice ◽  
Coronary Artery ◽  
Home Blood Pressure ◽  
Practice Population ◽  
Artery Disease

Small, Oral Dose of Clonidine Reduces the Incidence of Intraoperative Myocardial Ischemia in Patients Having Vascular Surgery

1996 ◽  
Vol 85 (4) ◽  
pp. 706-712 ◽  
Author(s):  
Klaus-Dieter Stuhmeier ◽  
Bernd Mainzer ◽  
Jochen Cierpka ◽  
Wilhelm Sandmann ◽  
Jorg Tarnow
Keyword(s):  
Myocardial Infarction ◽  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Heart Rate ◽  
Coronary Artery ◽  
Myocardial Ischemia ◽  
Oral Dose ◽  
Fluid Volume ◽  
Arterial Blood ◽  
Artery Disease

Background Most new perioperative myocardial ischemic episodes occur in the absence of hypertension or tachycardia. The ability of alpha 2-adrenoceptor agonists to inhibit central sympathetic outflow may benefit patients with coronary artery disease by increasing the myocardial oxygen supply and -demand ratio. Methods A randomized double-blind study design was used in 297 patients scheduled to have elective vascular surgical procedures to evaluate the effects of 2 micrograms/kg-1 oral clonidine (n = 145) or placebo (n = 152) on the incidence of perioperative myocardial ischemic episodes, myocardial infarction, and cardiac death. Continuous real-time S-T segment trend analysis (lead II and V5) was performed during anesthesia and surgery and correlated with arterial blood pressure and heart rate before and during ischemic events. Dose requirements for vasoactive and antiischemic drugs to control blood pressure and heart rate as well as episodes of myocardial ischemia (i.e., catecholamines, beta-adrenoceptor antagonists, nitrates, and systemic vasodilators) and fluid volume load were recorded. Results Administration of clonidine reduced the incidence of perioperative myocardial ischemic episodes from 39% (59 of 152) to 24% (35 of 145) (P < 0.01). Hemodynamic patterns, percentage of ischemic time, and the number of ischemic episodes per patient did not differ. Nonfatal myocardial infarction developed after operation in four patients receiving placebo compared with none receiving clonidine (day 2 to 21; P = 0.07). The incidence of fatal cardiac events (1 vs. 2) was not different. Dose requirements for vasoactive and antiischemic drugs did not differ between the groups, but the amount of presurgical fluid volume was slightly greater in patients receiving clonidine (951 +/- 388 vs. 867 +/- 381 ml; P < 0.03). Conclusion A small oral dose of clonidine, given prophylactically, can reduce the incidence of perioperative myocardial ischemic episodes without affecting hemodynamic stability in patients with suspected or documented coronary artery disease.

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