scholarly journals Framingham Stroke Risk Profile is related to cerebral small vessel disease progression and lower cognitive performance in patients with hypertension

2018 ◽  
Vol 20 (2) ◽  
pp. 240-245 ◽  
Author(s):  
Renske Uiterwijk ◽  
Julie Staals ◽  
Marjolein Huijts ◽  
Peter W. de Leeuw ◽  
Abraham A. Kroon ◽  
...  
Keyword(s):  
Disease Progression ◽  
Cognitive Performance ◽  
Stroke Risk ◽  
Small Vessel Disease ◽  
Risk Profile ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

Assessment of cerebral small vessel disease predicts individual stroke risk

2012 ◽  
Vol 83 (12) ◽  
pp. 1174-1179 ◽  
Author(s):  
Mariëlle M F Poels ◽  
Ewout W Steyerberg ◽  
Renske G Wieberdink ◽  
Albert Hofman ◽  
Peter J Koudstaal ◽  
...  
Keyword(s):  
Stroke Risk ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease

scholarly journals Large Perivascular Spaces Visible on Magnetic Resonance Imaging, Cerebral Small Vessel Disease Progression, and Risk of Dementia

2017 ◽  
Vol 74 (9) ◽  
pp. 1105 ◽  
Author(s):  
Jie Ding ◽  
Sigurður Sigurðsson ◽  
Pálmi V. Jónsson ◽  
Gudny Eiriksdottir ◽  
Andreas Charidimou ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Disease Progression ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Perivascular Spaces ◽  
Resonance Imaging ◽  
Vessel Disease

scholarly journals Association of cerebral small vessel disease and cognitive decline after intracerebral hemorrhage

Neurology ◽  
2020 ◽  
pp. 10.1212/WNL.0000000000011050
Author(s):  
Marco Pasi ◽  
Lansing Sugita ◽  
Li Xiong ◽  
Andreas Charidimou ◽  
Gregoire Boulouis ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Dementia Diagnosis ◽  
Vessel Disease ◽  
Ct Data ◽  
New Onset

Objective:We sought to determine whether MRI-based Cerebral Small Vessel Disease (CSVD) burden assessment, in addition to clinical and CT data, improved prediction of cognitive impairment after spontaneous Intracerebral Hemorrhage (ICH).Methods:We analyzed data from ICH survivors enrolled in a single-center prospective study. We employed three validated CSVD burden scores: global, cerebral amyloid angiopathy (CAA)-specific, hypertensive arteriopathy (HTNA)-specific. We quantified cognitive performance by administering the modified Telephone Interview for Cognitive Status (TICS-m) test. We utilized linear mixed models to model cognitive decline rates, and survival models for new-onset dementia. We calculated CSVD scores’ cut-offs to maximize predictive performance for dementia diagnosis.Results:We enrolled 612 ICH survivors, and followed them for a median of 46.3 months (Inter-Quartile Range: 35.5-58.7). A total of 214/612 (35%) participants developed dementia. Higher global CSVD scores at baseline were associated with faster cognitive decline (Coeff -0.25, Standard Error [SE] 0.02) and dementia risk (Sub-Hazard Ratio 1.35, 95% CI 1.10-1.65). The global score outperformed the CAA and HTNA scores in predicting post-ICH dementia (all p<0.05). Compared to a model including readily available clinical and CT data, inclusion of the global CSVD score resulted in improved prediction of post-ICH dementia (Area Under the Curve [AUC] 0.89, SE 0.02 vs. AUC 0.81, SE 0.03, p = 0.008 for comparison). Global CSVD scores ≥ 2 had highest sensitivity (83%) and specificity (91%) for dementia diagnosis.Conclusions:A validated MRI-based CSVD score is associated with cognitive performance after ICH, and improved diagnostic accuracy for predicting new onset of dementia.

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