scholarly journals Association between mortality and blood pressure variability in hypertensive and normotensive elders: A cohort study

2017 ◽  
Vol 19 (8) ◽  
pp. 753-756 ◽  
Author(s):  
Avraham Weiss ◽  
Yichayaou Beloosesky ◽  
Nira Koren-Morag ◽  
Alon Grossman
Keyword(s):  
Blood Pressure ◽  
Cohort Study ◽  
Blood Pressure Variability

scholarly journals Effect of visit-to-visit blood pressure variability on cardiovascular events in populations with different body mass indexes: a prospective cohort study

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e035836
Author(s):  
Haojia Chen ◽  
Youren Chen ◽  
Weiqiang Wu ◽  
Jianhuan Huang ◽  
Zekai Chen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cohort Study ◽  
Systolic Blood Pressure ◽  
Prospective Cohort ◽  
Cardiovascular Events ◽  
Blood Pressure Variability ◽  
Risk Model ◽  
Normal Weight ◽  
Weight Group ◽  
Body Mass Indexes

ObjectiveThis study was performed to explore the effects of visit-to-visit blood pressure variability (BPV) on cardiovascular events (CVEs) in people with various body mass indexes (BMIs).DesignProspective cohort study.SettingThe average real variability of systolic blood pressure (ARVSBP) was the indicator for visit-to-visit BPV. The participants were divided into three groups: normal weight, overweight and obesity. We further divided these groups into four subgroups based on the ARVSBP. A Cox regression model was used to calculate the HRs of the ARVSBP on CVEs in the same and different BMI groups. Additionally, a competitive risk model was used to calculate the HRs of the ARVSBP on CVEs in the same BMI group.ParticipantsIn total, 41 043 individuals met the inclusion criteria (no historical CVEs or tumours, no incidence of CVEs or tumours and no death during the four examinations) and had complete systolic blood pressure and BMI data.ResultsA total of 868 CVEs occurred. The cumulative incidence of CVEs increased as ARVSBP rose in both the normal weight and overweight groups. In same BMI groups, the risk of CVEs significantly increased as ARVSBP increased only in the normal weight group (highest quartiles of ARVSBP: HR (95% CI) 2.20 (1.46–3.31)). In the different BMI groups, the risk of CVEs in the ARVSBP subgroup in each BMI group was higher than that the least quintile of ARVSBP in the normal weight group (highest quartiles of ARVSBP in obesity: HR (95% CI) 2.28 (1.47–3.55)). The result of the competitive risk model did not change.ConclusionsAs BMI and ARVSBP increase, the risk of CVEs increases. However, the risk of visit-to-visit BPV on CVEs varies in different BMI groups, especially in people of normal weight.Trial registration numberCHiCTR-TNC1100 1489.

Blood pressure variability and the risk of fracture: a nationwide cohort study

2021 ◽  
Author(s):  
Jung Eun Yoo ◽  
Ji Won Yoon ◽  
Hyo Eun Park ◽  
Kyungdo Han ◽  
Dong Wook Shin
Keyword(s):  
Blood Pressure ◽  
Cohort Study ◽  
Hip Fractures ◽  
Blood Pressure Variability ◽  
Positive Association ◽  
Population Based ◽  
Outcome Data ◽  
National Health Insurance System ◽  
Risk Of Fracture ◽  
Quartile Group

Abstract Context Although blood pressure variability (BPV) is associated with various health outcomes, only one study suggested that BPV is correlated with hip fractures. As cardiovascular disease and fractures share similar pathophysiology, there might be a link between BPV and fractures. Objective To investigate the association between BPV and the incident fractures. Design Retrospective cohort study. Setting Population-based, using the Korean National Health Insurance System database. Patients or Other Participants A total of 3,256,070 participants aged 50 and above who participated in ≥3 health examinations within the previous five years, including the index year (2009-2010), were included. Outcome data was obtained through the end of 2016. Exposure BPV was calculated using variability independent of the mean. High variability was defined as the highest quartile of variability. Main Outcome Measures Newly diagnosed fractures. Results During the median follow-up of 7.0 years, there were 337,045 cases of any fracture (10.4%). After adjusting for age, sex, income, lifestyle factors, and comorbidities, a higher risk of fracture was observed with higher quartiles of BPV than the lowest quartile group: the adjusted hazard ratios (95% confidence intervals) for incident any fracture were 1.07 (1.06–1.08) in the higher quartile of systolic BPV, 1.06 (1.05–1.07) in that of diastolic BPV, and 1.07 (1.06–1.08) in that of both systolic and diastolic BPV. Consistent results were noted for vertebral fractures and hip fractures, as well as in various subgroup analyses. Conclusions A positive association was noted between higher BPV and fracture incidence. BPV is an independent predictor for developing fracture.

scholarly journals Age-specific associations of blood pressure variability with cardiovascular disease and mortality: 10-year Diabetes cohort study

2020 ◽  
Author(s):  
Eric Yuk Fai WAN ◽  
Esther Yee Tak Yu ◽  
Weng Yee Chin ◽  
Jessica K. Barrett ◽  
Ian Chi Kei Wong ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Cohort Study ◽  
Systolic Blood Pressure ◽  
Mortality Risk ◽  
Blood Pressure Variability ◽  
Hazard Ratio ◽  
Diabetic Patients ◽  
Age Group ◽  
Systolic Blood Pressure Variability

Abstract Background: This study evaluated the age-specific association of systolic blood pressure variability with cardiovascular disease and mortality in Type-2 diabetic patients. The detrimental effects of increased systolic blood pressure variability on cardiovascular disease and mortality risk in diabetic patients remains unclear. Methods: A retrospective cohort study investigated 155,982 diabetic patients aged from 45 to 84 years old without prior history of cardiovascular disease at baseline from 2008 to 2010). systolic blood pressure variability was estimated using systolic blood pressure standard deviation from mixed effects model to reduce regression dilution bias. Age-specific associations (45-54; 55-64; 65-74; 75-84 years) between systolic blood pressure variability, cardiovascular disease and mortality risk were assessed by Cox regression adjusted for patient characteristics with subgroups stratified by subject baseline characteristics. Results: After a median follow-up of 9.7 years (16.4 million person-years), 49,816 events (including 34,039 events with and 29,211 mortalities) were identified. Elevated and independent systolic blood pressure variability was positively and log-linearly associated with higher risk on cardiovascular disease and mortality among all age groups, without evidence of a specific threshold. The cardiovascular disease and mortality risk per 5mmHg increase in systolic blood pressure variability within 45-54 years age group is over three times higher than the 70-79 years age group [Hazard Ratio: 1.66 (1.49, 1.85) vs. Hazard Ratio: 1.19 (1.15, 1.23)]. The significant associations remained consistent among all subgroups. Patients with younger age, lower systolic blood pressure and comorbidity with more types of anti-hypertensive prescription drug users had higher hazard ratios. Conclusions: The findings suggest that systolic blood pressure variability was strongly associated with cardiovascular disease and mortality risk without evidence of a specific threshold in diabetic population. In addition to optimize blood pressure control, the systolic blood pressure variability particularly for younger patients should be monitored and evaluated in routine practice.

scholarly journals The association between 24-h blood pressure variability and major adverse cardiac events (MACE) in hospitalized patients with acute myocardial infarction: a retrospective cohort study

2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Harefa ◽  
Ika Prasetya Wijaya ◽  
Muhadi ◽  
Cleopas Martin Rumende ◽  
Sally Aman Nasution ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Blood Pressure ◽  
Acute Myocardial Infarction ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Blood Pressure Variability ◽  
Major Adverse Cardiac Events ◽  
Cardiac Events ◽  
Adverse Cardiac Events

Abstract Background Acute myocardial infarction (AMI) is major cardiovascular disease that causes high morbidity and mortality. In AMI, ischemia and necrosis affected some cardiomyocytes leading to a decrease in myocardial contractility which is followed by an acute proinflammation reaction and increased sympathetic tone. Meanwhile, high blood pressure variability (BPV) causing an increased left ventricular workload, heart rate, myocardial oxygen demand and induces proinflamations and endothelial dysfunction. Therefore a high BPV and its associated pathological effects are likely to aggravate the physiological function of the heart and affect the emergence of acute cardiac complications in AMI patients. This study aims to investigate the association’s between short-term BPV and major adverse cardiac events (MACE) in AMI patients. This retrospective cohort study used simple random sampling to identify AMI patients who were hospitalized at Cipto Mangunkusumo National Hospital between January 2018 and December 2019. Mann Withney was performed to investigate the association between BPV and MACE. Results The average systolic BPV value which was calculated as standard deviation (SD) and average real variability (ARV) was higher in the MACE group than in the non-MACE group. Systolic SD and systolic ARV in the MACE group were 13.28 ± 5.41 mmHg and 9.88 ± 3.81 mmHg respectively. In the non-MACE group, systolic SD and systolic ARV were 10.76 (4.59–26.17) mmHg and 8.65 (3.22–19.35) mmHg respectively. There was no significant association between BPV and MACE. However, there were significant differences between systolic SD and systolic ARV in patients with hypertension who experienced MACE and patients without hypertension who experienced MACE. Conclusions The BPV of AMI patients who experience MACE was higher than that of non-MACE AMI patients. There was no significant association between BPV ​​and MACE during the acute phase of AMI.

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