Circadian periodicity affects The Type of ventricular arrhythmias and efficacy of Implantable defibrillator therapies

2021 ◽  
Author(s):  
Pasquale Vergara ◽  
Carlo Pignalberi ◽  
Ennio C. Pisanò ◽  
Giampiero Maglia ◽  
Paolo Della Bella ◽  
...  
Keyword(s):  
Ventricular Arrhythmias ◽  
Implantable Defibrillator ◽  
Circadian Periodicity

Nonpharmacological therapy for malignant ventricular arrhythmias: Implantable defibrillator trials

1996 ◽  
Vol 38 (6) ◽  
pp. 429-444 ◽  
Author(s):  
Sanjeev Saksena ◽  
Gunter Breithardt ◽  
Paul Dorian ◽  
H. Leon Greene ◽  
Nandini Madan ◽  
...  
Keyword(s):  
Ventricular Arrhythmias ◽  
Implantable Defibrillator ◽  
Nonpharmacological Therapy

scholarly journals Role of the implantable defibrillator among elderly patients with a history of life-threatening ventricular arrhythmias

2007 ◽  
Vol 28 (14) ◽  
pp. 1746-1749 ◽  
Author(s):  
Jeffrey S. Healey ◽  
Al P. Hallstrom ◽  
Karl-Heinz Kuck ◽  
Girish Nair ◽  
Eleanor P. Schron ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Ventricular Arrhythmias ◽  
Implantable Defibrillator ◽  
Life Threatening ◽  
History Of

scholarly journals Pediatric Malignant Arrhythmias Caused by Rare Homozygous Genetic Variants in TRDN: A Comprehensive Interpretation

2021 ◽  
Vol 8 ◽  
Author(s):  
Georgia Sarquella-Brugada ◽  
Anna Fernandez-Falgueras ◽  
Sergi Cesar ◽  
Elena Arbelo ◽  
Paloma Jordà ◽  
...  
Keyword(s):  
Ventricular Arrhythmias ◽  
Rare Variants ◽  
Early Recognition ◽  
Hot Spot ◽  
Pediatric Population ◽  
Specific Area ◽  
Implantable Defibrillator ◽  
Genetic Alterations ◽  
Malignant Arrhythmias ◽  
Genotype Correlation

Aim: To perform a comprehensive phenotype-genotype correlation of all rare variants in Triadin leading to malignant arrhythmias in pediatrics.Methods: Triadin knockout syndrome is a rare entity reported in pediatric population. This syndrome is caused by rare variants in the TRDN gene. Malignant ventricular arrhythmias and sudden cardiac death can be a primary manifestation of disease. Although pharmacological measures are effective, some patients require an implantable defibrillator due to high risk of arrhythmogenic episodes.Main Results: Fourteen rare genetic alterations in TRDN have been reported to date. All of these potentially pathogenic alterations are located in a specific area of TRDN, highlighting this hot spot as an arrhythmogenic gene region.Conclusions: Early recognition and comprehensive interpretation of alterations in Triadin are crucial to adopt preventive measures and avoid malignant arrhythmogenic episodes in pediatric population.

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