scholarly journals First interventional exchange of a left transvenous phrenic nerve stimulation lead from the novel remedē system

2020 ◽  
Vol 31 (11) ◽  
pp. 3056-3060
Author(s):  
Klaus‐Jürgen Gutleben ◽  
Thomas Eitz ◽  
Randy Westlund ◽  
Jan F. Gummert ◽  
Philipp Sommer ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Phrenic Nerve ◽  
The Novel ◽  
Phrenic Nerve Stimulation

Botzinger complex region role in phrenic-to-phrenic inhibitory reflex of cat

1989 ◽  
Vol 67 (4) ◽  
pp. 1364-1370 ◽  
Author(s):  
D. F. Speck
Keyword(s):  
Nerve Stimulation ◽  
Phrenic Nerve ◽  
Inhibitory Response ◽  
Phrenic Nerve Stimulation ◽  
Bötzinger Complex ◽  
Before And After ◽  
Pass Through ◽  
Bilateral Lesions ◽  
Decerebrate Cats ◽  
Inhibitory Reflex

Neuronal recordings, microstimulation, and electrolytic and chemical lesions were used to examine the involvement of the Botzinger Complex (BotC) in the bilateral phrenic-to-phrenic inhibitory reflex. Experiments were conducted in decerebrate cats that were paralyzed, ventilated, thoracotomized, and vagotomized. Microelectrode recordings within the BotC region revealed that some neurons were activated by phrenic nerve stimulation (15 of 69 expiratory units, 9 of 67 inspiratory units, and 19 nonrespiratory-modulated units) at average latencies similar to the onset latency of the phrenic-to-phrenic inhibition. In addition, microstimulation within the BotC caused a short latency transient inhibition of phrenic motor activity. In 17 cats phrenic neurogram responses to threshold and supramaximal (15 mA) stimulation of phrenic nerve afferents were recorded before and after electrolytic BotC lesions. In 15 animals the inhibitory reflex was attenuated by bilateral lesions. Because lesion of either BotC neurons or axons of passage could account for this attenuation, in eight experiments the phrenic-to-phrenic inhibitory responses were recorded before and after bilateral injections of 5 microM kainic acid (30–150 nl) into the BotC. After chemical lesions, the inhibitory response to phrenic nerve stimulation remained; however, neuronal activity typical of the BotC could not be located. These results suggest that axons important in producing the phrenic-to-phrenic reflex pass through the region of the BotC, but that BotC neurons themselves are not necessary for this reflex.

Mapping for Acute Transvenous Phrenic Nerve Stimulation Study (MAPS Study)

2017 ◽  
Vol 40 (3) ◽  
pp. 294-300
Author(s):  
LUKAS R.C. DEKKER ◽  
BART GERRITSE ◽  
AVRAM SCHEINER ◽  
LILIAN KORNET
Keyword(s):  
Nerve Stimulation ◽  
Phrenic Nerve ◽  
Phrenic Nerve Stimulation

Excitation of dorsal and ventral respiratory group neurons by phrenic nerve afferents

1987 ◽  
Vol 62 (3) ◽  
pp. 946-951 ◽  
Author(s):  
D. F. Speck ◽  
W. R. Revelette
Keyword(s):  
Nerve Stimulation ◽  
Phrenic Nerve ◽  
Afferent Input ◽  
Neuronal Responses ◽  
Onset Latency ◽  
Phrenic Nerve Stimulation ◽  
Group Iii ◽  
Neuronal Excitation ◽  
Dorsal Columns ◽  
The Difference

The projections of phrenic nerve afferents to neurons in the dorsal (DRG) and ventral (VRG) respiratory group were studied in anesthetized, paralyzed, and vagotomized cats. Extracellular recordings of neuronal responses to vagal nerve and cervical phrenic nerve stimulation (CPNS) indicated that about one-fourth of the DRG respiratory-modulated neurons were excited by phrenic nerve afferents with an onset latency of approximately 20 ms. In addition, non-respiratory-modulated neurons within the DRG were recruited by CPNS. Although some convergence of vagal and phrenic afferent input was observed, most neurons were affected by only one type of afferent. In contrast to the DRG, only 3 out of 28 VRG respiratory-modulated neurons responded to CPNS. A second study determined that most of these neuronal responses were due to activation of diaphragmatic afferents since 90% of the DRG units activated by CPNS were also excited at a longer latency by thoracic phrenic nerve stimulation. The difference in onset latency of neuronal excitation indicates an afferent peripheral conduction velocity of about 10 m/s, which suggests that they are predominately small myelinated fibers (group III) making paucisynaptic connections with DRG neurons. Decerebration, decerebellation, and bilateral transection of the dorsal columns at C2 do not abolish the neuronal responses to cervical PNS.

Effects of unilateral phrenic nerve stimulation on tidal volume

Herz ◽  
2014 ◽  
Vol 39 (1) ◽  
pp. 84-86 ◽  
Author(s):  
O. Oldenburg ◽  
T. Bitter ◽  
H. Fox ◽  
D. Horstkotte ◽  
K.-J. Gutleben
Keyword(s):  
Tidal Volume ◽  
Nerve Stimulation ◽  
Phrenic Nerve ◽  
Phrenic Nerve Stimulation
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