Positron emission tomography absolute stress myocardial blood flow for risk stratification in nonischemic cardiomyopathy

2020 ◽  
Vol 31 (5) ◽  
pp. 1137-1146
Author(s):  
Thomas G. Middour ◽  
Todd M. Rosenthal ◽  
Freddy M. Abi‐Samra ◽  
Michael L. Bernard ◽  
Sammy Khatib ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Risk Stratification ◽  
Myocardial Blood Flow ◽  
Emission Tomography ◽  
Nonischemic Cardiomyopathy ◽  
Positron Emission ◽  
Stress Myocardial Blood Flow

scholarly journals Global and segmental absolute stress myocardial blood flow in prediction of cardiac events: [15O] water positron emission tomography study

2020 ◽  
Author(s):  
Esa Harjulahti ◽  
Teemu Maaniitty ◽  
Wail Nammas ◽  
Iida Stenström ◽  
Fausto Biancari ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Characteristic Curve ◽  
Obstructive Coronary Artery Disease ◽  
Cardiovascular Death ◽  
Emission Tomography ◽  
Cardiac Events ◽  
Positron Emission ◽  
Stress Myocardial Blood Flow

Abstract Purpose We evaluated the value of reduced global and segmental absolute stress myocardial blood flow (sMBF) quantified by [15O] water positron emission tomography (PET) for predicting cardiac events in patients with suspected obstructive coronary artery disease (CAD). Methods Global and segmental sMBF during adenosine stress were retrospectively quantified in 530 symptomatic patients who underwent [15O] water PET for evaluation of coronary stenosis detected by coronary computed tomography angiography. Results Cardiovascular death, myocardial infarction, or unstable angina occurred in 28 (5.3%) patients at a 4-year follow-up. Reduced global sMBF was associated with events (area under the receiver operating characteristic curve 0.622, 95% confidence interval (95% CI) 0.538–0.707, p = 0.006). Reduced global sMBF (< 2.2 ml/g/min) was found in 22.8%, preserved global sMBF despite segmentally reduced sMBF in 35.3%, and normal sMBF in 41.9% of patients. Compared with normal sMBF, reduced global sMBF was associated with the highest risk of events (adjusted hazard ratio (HR) 6.970, 95% CI 2.271–21.396, p = 0.001), whereas segmentally reduced sMBF combined with preserved global MBF predicted an intermediate risk (adjusted HR 3.251, 95% CI 1.030–10.257, p = 0.044). The addition of global or segmental reduction of sMBF to clinical risk factors improved risk prediction (net reclassification index 0.498, 95% CI 0.118–0.879, p = 0.010, and 0.583, 95% CI 0.203–0.963, p = 0.002, respectively). Conclusion In symptomatic patients evaluated for suspected obstructive CAD, reduced global sMBF by [15O] water PET identifies those at the highest risk of adverse cardiac events, whereas segmental reduction of sMBF with preserved global sMBF is associated with an intermediate event risk.

scholarly journals Measurement of heritability of myocardial blood flow by positron emission tomography: the Twins Heart Study

Heart ◽  
2012 ◽  
Vol 98 (6) ◽  
pp. 495-499 ◽  
Author(s):  
Shaoyong Su ◽  
John Votaw ◽  
Tracy Faber ◽  
Durreshahwar Khan ◽  
J Douglas Bremner ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Emission Tomography ◽  
Positron Emission ◽  
Heart Study

scholarly journals Assessment of Myocardial Blood Flow and Cardiac FDG Uptake Using Positron Emission Tomography

2017 ◽  
Vol 3 (1) ◽  
pp. 205-209 ◽  
Author(s):  
Osamu Manabe ◽  
Masanao Naya ◽  
Keiichiro Yoshinaga ◽  
Noriko Oyama-Manabe ◽  
Hiroshi Ohira ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Myocardial Blood Flow ◽  
Emission Tomography ◽  
Fdg Uptake ◽  
Positron Emission
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