Long‐term efficacy and safety of adjunctive ethanol infusion into the vein of Marshall during catheter ablation for nonparoxysmal atrial fibrillation

2019 ◽  
Vol 30 (8) ◽  
pp. 1215-1228 ◽  
Author(s):  
Chih‐Min Liu ◽  
Li‐Wei Lo ◽  
Yenn‐Jiang Lin ◽  
Chin‐Yu Lin ◽  
Shih‐Lin Chang ◽  
...  
EP Europace ◽  
2020 ◽  
Author(s):  
Jorge Romero ◽  
Mohamed Gabr ◽  
Kavisha Patel ◽  
David Briceno ◽  
Juan Carlos Diaz ◽  
...  

Abstract Aims Left atrial appendage electrical isolation (LAAEI) has been shown to improve freedom from all-atrial arrhythmia recurrence in patients with non-paroxysmal atrial fibrillation (AF). The aim of this study is to investigate the long-term efficacy and safety outcomes of LAAEI in patients with non-paroxysmal AF undergoing catheter ablation. Methods and results A systematic review of Medline, Cochrane, and Embase was performed for clinical studies evaluating the benefit of LAAEI in non-paroxysmal AF. Nine studies with a total of 2336 patients were included (mean age: 65 ± 9 years, 63% male). All studies included patients with persistent AF, long-standing persistent AF, or both. At a mean follow-up of 40.5 months, patients who underwent LAAEI had significantly higher freedom from all-atrial arrhythmia recurrence than patients who underwent standard ablation alone [69.3% vs. 46.4%; risk ratio (RR) 0.54; 95% confidence interval (CI) 0.42–0.69; P < 0.0001]. A 46% relative risk reduction and 22.9% absolute risk reduction in atrial-arrhythmia recurrence was noted with LAAEI. Rates of cerebral thromboembolism were not significantly different between the two groups (LAAEI 3% vs. standard ablation 1.6%, respectively; RR 1.76; 95% CI 0.61–5.04; P = 0.29). Furthermore, there was no significant difference in the acute procedural complication rates between the two groups (LAAEI 4% vs. standard ablation 3%, respectively; RR 1.29; 95% CI 0.83–2.02; P = 0.26). Conclusion At long-term follow-up, LAAEI led to a significantly higher improvement in freedom from all-atrial arrhythmia recurrence in patients with non-paroxysmal AF, when compared to standard ablation alone. Importantly, this benefit was achieved without an increased risk of acute procedural complications or cerebral thromboembolic events.


Heart ◽  
2010 ◽  
Vol 96 (17) ◽  
pp. 1372-1378 ◽  
Author(s):  
R. J. Hunter ◽  
T. J. Berriman ◽  
I. Diab ◽  
V. Baker ◽  
M. Finlay ◽  
...  

Author(s):  
Koichi Inoue ◽  
Kenzo Hirao ◽  
Koichiro Kumagai ◽  
Masaomi Kimura ◽  
Yasushi Miyauchi ◽  
...  

2013 ◽  
Vol 24 (7) ◽  
pp. 731-738 ◽  
Author(s):  
ALESSANDRO BLANDINO ◽  
ELISABETTA TOSO ◽  
MARCO SCAGLIONE ◽  
MATTEO ANSELMINO ◽  
FEDERICO FERRARIS ◽  
...  

Author(s):  
M. E. Protasov ◽  
R. E. Batalov ◽  
M. S. Khlynin ◽  
E. A. Protasova ◽  
I. V. Kisteneva ◽  
...  

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