The Use of Noninvasive Vagal Nerve Stimulation to Inhibit Sympathetically Induced Sinus Node Acceleration: A Potential Therapeutic Approach for Inappropriate Sinus Tachycardia

2015 ◽  
Vol 27 (2) ◽  
pp. 217-223 ◽  
Author(s):  
XIAOYA ZHOU ◽  
LIPING ZHOU ◽  
SONGYUN WANG ◽  
LILEI YU ◽  
ZHUO WANG ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Therapeutic Approach ◽  
Sinus Tachycardia ◽  
Sinus Node ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Inappropriate Sinus Tachycardia

P1097Heart rate acceleration is a poor surrogate of complete parasympathetic denervation of sinus node during cardioneuroablation

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
D Wichterle ◽  
H Jansova ◽  
P Stiavnicky ◽  
P Peichl ◽  
R Cihak ◽  
...  
Keyword(s):  
Heart Rate ◽  
Sinus Rhythm ◽  
Nerve Stimulation ◽  
Sinus Node ◽  
Clinical Success Rate ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
High Frequency Stimulation ◽  
Baseline Heart Rate ◽  
Rate Acceleration

Abstract Background Ablation of superior paraseptal ganglionic plexi is invariantly associated with the acceleration of sinus rhythm. This is considered a favourable sign during cardioneuroablation for the treatment of recurrent neurally-mediated cardioinhibitory syncope or symptomatic sinus bradycardia. Purpose In this retrospective study, we investigated whether the magnitude of sinus rhythm acceleration corresponds with directly assessed sinus nodal parasympathetic denervation. Methods The study included 48 patients (age: 39 ± 13 years, 58% males) who underwent cardioneuroablation in general anaesthesia. The procedural endpoint was non-responsiveness (i.e. loss of original cardioinhibitory response) of the sinus node to extracardiac high-frequency stimulation of the vagal nerve. The magnitude of sinus rhythm acceleration was compared between patients who reached or did not reach this endpoint. Results All patients had positive atropine test (baseline heart rate: 65 ± 14 bpm; post-atropine: 109 ± 22 bpm). Complete sinus nodal denervation as assessed by vagal nerve stimulation was achieved in 44/48 (92%) patients. Intraprocedurally, heart rate accelerated from 54 ± 11 to 85 ± 14 bpm (difference: 31 ± 10; median 29; interquartile range: 24–40; total range: 13–61 bpm). This change did not correlate with age and was not related to pre-procedural post-atropine sinus rhythm acceleration. There was no difference in heart rate acceleration between the patient with and without sinus nodal denervation (Figure). Conclusions Sinus rhythm acceleration is not reliable endpoint for cardioneuroablation. Guidance by extracardiac vagal nerve stimulation may help to tailor the procedures to increase the clinical success rate and, at the same time, to avoid patient overtreatment. Abstract Figure.

scholarly journals Noninvasive vagal nerve stimulation for gastroenterology pain disorders

2021 ◽  
Vol 11 (1) ◽  
pp. 89-96
Author(s):  
Andres Gottfried-Blackmore ◽  
Aida Habtezion ◽  
Linda Nguyen
Keyword(s):  
Chronic Pain ◽  
Abdominal Pain ◽  
Nerve Stimulation ◽  
Therapeutic Approach ◽  
Review Paper ◽  
Unmet Need ◽  
Chronic Abdominal Pain ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Gastrointestinal Disorders

Abdominal pain continues to be a major challenge and unmet need in clinical practice. Normalization of bidirectional gut-brain signaling has generated much interest as a therapeutic approach to treat chronic abdominal pain. Vagal nerve stimulation (VNS) is emerging as a potential non-pharmacologic strategy for the treatment of abdominal pain. In this review paper, we will summarize the etiologies of chronic pain in gastrointestinal disorders and discuss the rational for VNS as a therapeutic approach to chronic abdominal pain, with particular emphasis in the gammaCore stimulator which allows for noninvasive VNS.

scholarly journals GW26-e2399 The Use of Noninvasive Vagal Nerve Stimulation to Inhibit Sympathetically Induced Sinus Node Acceleration

2015 ◽  
Vol 66 (16) ◽  
pp. C88
Author(s):  
Liping Zhou ◽  
Xiaoya Zhou ◽  
Lilei Yu ◽  
Zhuo Wang ◽  
Songyun Wang ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Sinus Node ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation

Benefit of vagal nerve stimulation in epilepsia partialis continua: a case report

2006 ◽  
Vol 37 (03) ◽  
Author(s):  
C Bussmann ◽  
HM Meinck ◽  
HH Steiner ◽  
W Broxtermann ◽  
CG Bien ◽  
...  
Keyword(s):  
Case Report ◽  
Nerve Stimulation ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Epilepsia Partialis Continua
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