Stability of Rotors and Focal Sources for Human Atrial Fibrillation: Focal Impulse and Rotor Mapping (FIRM) of AF Sources and Fibrillatory Conduction

2014 ◽  
Vol 25 (12) ◽  
pp. 1284-1292 ◽  
Author(s):  
VIJAY SWARUP ◽  
TINA BAYKANER ◽  
ARMAND ROSTAMIAN ◽  
JAMES P. DAUBERT ◽  
JOHN HUMMEL ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Fibrillatory Conduction ◽  
Human Atrial Fibrillation

Abstract 18492: Phase Analysis Detects Human Atrial Fibrillation Sources While Classical Activation Mapping May Not: Reconciling Classical and Computational Mapping

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Junaid A Zaman ◽  
Gautam G Lalani ◽  
Tina Baykaner ◽  
Shirley Park ◽  
David E Krummen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Phase Analysis ◽  
Atrial Tachycardia ◽  
Source Detection ◽  
Perfect Agreement ◽  
Classical Activation ◽  
Electrode Noise ◽  
Fibrillatory Conduction ◽  
Activation Mapping ◽  
Human Atrial Fibrillation

Introduction: The mechanisms maintaining human persistent AF are elusive. It is striking how most optical mapping studies in animal and recently human AF show rotors and focal sources, while most classical activation mapping studies of electrograms do not. We tested the hypothesis that sites in human persistent AF showing rotors by phase analysis may, due to precession (‘wobble’) and fibrillatory collision, rarely reveal sources in activation maps. Methods: We studied 25 patients with persistent AF (LA 47 mm, CHADS2=1.9), in whom phase-mapping of electrograms from 64 pole baskets revealed rotors/focal sources where ablation terminated AF. Electrograms (fig A) were annotated (Matlab) using minimum dV/dt (unipoles, fig B) and peak amplitude criteria (bipoles) to create contours (isochrones), that were classified into a) complete, b) partial or c) unresolvable sources. Results: In each case, ablation at phase-identified rotors/sources (4.0±5.7 mins) terminated persistent AF to sinus rhythm (fig C, 64%) or atrial tachycardia. Notably, isochrones detected sources in only 5/25 (20%) of cases (fig D), more easily in unipolar than bipolar signals. Isochrones revealed partial sources in 11 (44%) and were unresolvable in 9 (36%). Source detection in classical maps was obscured by low signal: noise, varying sequence (rotor precession), or electrode noise that phase analysis resolved by analyzing neighboring sites (fig E). The figure summarizes these steps for a case with perfect agreement between activation and phase maps. Conclusions: Rotors and focal sources for human persistent AF detected by phase analysis were mostly undetected in activation maps, due to rotor precession and fibrillatory conduction. These data may inform approaches to revise classical criteria to better map AF.

The role of angiotensin in electrophysiological gap junction remodeling in human atrial fibrillation

2004 ◽  
Vol 52 (S 1) ◽  
Author(s):  
S Dhein ◽  
A Boldt ◽  
J Garbade ◽  
L Polontchouk ◽  
U Wetzel ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Gap Junction ◽  
Human Atrial Fibrillation

scholarly journals A Myocardial Nox2 Containing NAD(P)H Oxidase Contributes to Oxidative Stress in Human Atrial Fibrillation

2005 ◽  
Vol 97 (7) ◽  
pp. 629-636 ◽  
Author(s):  
Young M. Kim ◽  
Tomasz J. Guzik ◽  
Yin Hua Zhang ◽  
Mei Hua Zhang ◽  
Hassan Kattach ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atrial Fibrillation ◽  
Human Atrial Fibrillation

Action Potential Dynamics in Human Atrial Fibrillation

2019 ◽  
pp. 333-345 ◽  
Author(s):  
Junaid Ahmed Bakhtiyar Zaman ◽  
Sanjiv M. Narayan ◽  
Michael R. Franz
Keyword(s):  
Atrial Fibrillation ◽  
Action Potential ◽  
Human Atrial Fibrillation

Electrical Remodeling in Human Atrial Fibrillation Influences Post-Cardioversion Atrial Mechanical Dysfunction and Early Relapse

1999 ◽  
Vol 29 (8) ◽  
pp. 788 ◽  
Author(s):  
Gyo Seung Hwang ◽  
Young Hoon Kim ◽  
Hyun Soo Lee ◽  
Byung Soo Kim ◽  
Soo Jin Lee ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Electrical Remodeling ◽  
Early Relapse ◽  
Human Atrial Fibrillation
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