Macro‐scale variation and environmental predictors of flowering and fruiting phenology in the Chinese angiosperm flora

2020 ◽  
Vol 47 (11) ◽  
pp. 2303-2314
Author(s):  
Yanjun Du ◽  
Lingfeng Mao ◽  
Simon A. Queenborough ◽  
Richard Primack ◽  
Liza S. Comita ◽  
...  
Keyword(s):  
Environmental Predictors ◽  
Fruiting Phenology ◽  
Macro Scale ◽  
Scale Variation

scholarly journals Heterogeneity in Signaling Pathway Activity within Primary and between Primary and Metastatic Breast Cancer

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1345
Author(s):  
Márcia A. Inda ◽  
Paul van Swinderen ◽  
Anne van Brussel ◽  
Cathy B. Moelans ◽  
Wim Verhaegh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Tumor Heterogeneity ◽  
Metastatic Breast ◽  
Big Bang ◽  
Pi3k Pathway ◽  
Pathway Activity ◽  
Micro Scale ◽  
Macro Scale ◽  
Scale Variation

Targeted therapy aims to block tumor-driving signaling pathways and is generally based on analysis of one primary tumor (PT) biopsy. Tumor heterogeneity within PT and between PT and metastatic breast lesions may, however, impact the effect of a chosen therapy. Whereas studies are available that investigate genetic heterogeneity, we present results on phenotypic heterogeneity by analyzing the variation in the functional activity of signal transduction pathways, using an earlier developed platform to measure such activity from mRNA measurements of pathways’ direct target genes. Statistical analysis comparing macro-scale variation in pathway activity on up to five spatially distributed PT tissue blocks (n = 35), to micro-scale variation in activity on four adjacent samples of a single PT tissue block (n = 17), showed that macro-scale variation was not larger than micro-scale variation, except possibly for the PI3K pathway. Simulations using a “checkerboard clone-size” model showed that multiple small clones could explain the higher micro-scale variation in activity found for the TGFβ and Hedgehog pathways, and that intermediate/large clones could explain the possibly higher macro-scale variation of the PI3K pathway. While within PT, pathway activities presented a highly positive correlation, correlations weakened between PT and lymph node metastases (n = 9), becoming even worse for PT and distant metastases (n = 9), including a negative correlation for the ER pathway. While analysis of multiple sub-samples of a single biopsy may be sufficient to predict PT response to targeted therapies, metastatic breast cancer treatment prediction requires analysis of metastatic biopsies. Our findings on phenotypic intra-tumor heterogeneity are compatible with emerging ideas on a Big Bang type of cancer evolution in which macro-scale heterogeneity appears not dominant.

Tailoring microstructures of materials through biomimetics

1993 ◽  
Vol 51 ◽  
pp. 500-501
Author(s):  
Mehmet Sarikaya ◽  
Ilhan A. Aksay
Keyword(s):  
Chemical Properties ◽  
Design And Synthesis ◽  
Structure Sensitive ◽  
Macro Scale ◽  
Methods Of Synthesis ◽  
Successive Level ◽  
Engineering Materials ◽  
Physical And Chemical ◽  
And Chemical Properties ◽  
Synthesis Of Materials

Biomimetics involves investigation of structure, function, and methods of synthesis of biological composite materials. The goal is to apply this information to the design and synthesis of materials for engineering applications.Properties of engineering materials are structure sensitive through the whole spectrum of dimensions from nanometer to macro scale. The goal in designing and processing of technological materials, therefore, is to control microstructural evolution at each of these dimensions so as to achieve predictable physical and chemical properties. Control at each successive level of dimension, however, is a major challenge as is the retention of integrity between successive levels. Engineering materials are rarely fabricated to achieve more than a few of the desired properties and the synthesis techniques usually involve high temperature or low pressure conditions that are energy inefficient and environmentally damaging.In contrast to human-made materials, organisms synthesize composites whose intricate structures are more controlled at each scale and hierarchical order.

EFFECT OF THE MACRO-SCALE TOPOLOGY OVER THE EFFECTIVE DRAG COEFFICIENT IN DENSE GAS-SOLID FLUIDIZED FLOWS

2018 ◽  
Author(s):  
Seyed Reza Amini Niaki ◽  
Joseph Mouallem ◽  
Christian Milioli ◽  
Fernando Milioli
Keyword(s):  
Drag Coefficient ◽  
Dense Gas ◽  
Macro Scale

Underground waterlines

Focaal ◽  
2019 ◽  
pp. 1-14
Author(s):  
Denys Gorbach
Keyword(s):  
Macro Level ◽  
The Political ◽  
Macro Scale ◽  
Ethnographic Data ◽  
Economic Boom ◽  
Labor Hoarding ◽  
Large Enterprises

In order to explore factors conditioning the political quietude of Ukrainian labor, this article analyzes ethnographic data collected at two large enterprises: the Kyiv Metro and the privatized electricity supplier Kyivenergo. Focusing on a recent labor conflict, I unpack various contexts condensed in it. I analyze the hegemonic configuration developed in the early 1990s, at the workplace and at the macro level, and follow its later erosion. This configuration has been based on labor hoarding, distribution of nonwage resources, and patronage networks, featuring the foreman as the nodal figure. On the macro scale, it relied on the mediation by unions, supported by resources accumulated during the Soviet era and the economic boom of the 2000s. The depletion of these resources has spelled the ongoing crisis of this configuration.

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