Genetics of tolerance to heat stress in milk yield of dairy buffaloes assessed by a reaction norm model

2021 ◽  
Author(s):  
Gabriela Stefani ◽  
Mário Luiz Santana Júnior ◽  
Lenira El Faro ◽  
Humberto Tonhati
Keyword(s):  
Heat Stress ◽  
Milk Yield ◽  
Reaction Norm ◽  
Norm Model

scholarly journals Genotype-by-environment interaction in Holstein heifer fertility traits using single-step genomic reaction norm models

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Rui Shi ◽  
Luiz Fernando Brito ◽  
Aoxing Liu ◽  
Hanpeng Luo ◽  
Ziwei Chen ◽  
...  
Keyword(s):  
Heat Stress ◽  
Dairy Cattle ◽  
Candidate Genes ◽  
Heat Tolerance ◽  
Reaction Norm ◽  
Single Step ◽  
Conception Rate ◽  
Critical Periods ◽  
Genotype By Environment ◽  
Fertility Traits

Abstract Background The effect of heat stress on livestock production is a worldwide issue. Animal performance is influenced by exposure to harsh environmental conditions potentially causing genotype-by-environment interactions (G × E), especially in highproducing animals. In this context, the main objectives of this study were to (1) detect the time periods in which heifer fertility traits are more sensitive to the exposure to high environmental temperature and/or humidity, (2) investigate G × E due to heat stress in heifer fertility traits, and, (3) identify genomic regions associated with heifer fertility and heat tolerance in Holstein cattle. Results Phenotypic records for three heifer fertility traits (i.e., age at first calving, interval from first to last service, and conception rate at the first service) were collected, from 2005 to 2018, for 56,998 Holstein heifers raised in 15 herds in the Beijing area (China). By integrating environmental data, including hourly air temperature and relative humidity, the critical periods in which the heifers are more sensitive to heat stress were located in more than 30 days before the first service for age at first calving and interval from first to last service, or 10 days before and less than 60 days after the first service for conception rate. Using reaction norm models, significant G × E was detected for all three traits regarding both environmental gradients, proportion of days exceeding heat threshold, and minimum temperature-humidity index. Through single-step genome-wide association studies, PLAG1, AMHR2, SP1, KRT8, KRT18, MLH1, and EOMES were suggested as candidate genes for heifer fertility. The genes HCRTR1, AGRP, PC, and GUCY1B1 are strong candidates for association with heat tolerance. Conclusions The critical periods in which the reproductive performance of heifers is more sensitive to heat stress are trait-dependent. Thus, detailed analysis should be conducted to determine this particular period for other fertility traits. The considerable magnitude of G × E and sire re-ranking indicates the necessity to consider G × E in dairy cattle breeding schemes. This will enable selection of more heat-tolerant animals with high reproductive efficiency under harsh climatic conditions. Lastly, the candidate genes identified to be linked with response to heat stress provide a better understanding of the underlying biological mechanisms of heat tolerance in dairy cattle.

scholarly journals Characterization of Short-Term Heat Stress in Holstein Dairy Cows Using Altered Indicators of Metabolomics, Blood Parameters, Milk MicroRNA-216 and Characteristics

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 722
Author(s):  
Jang-Hoon Jo ◽  
Jalil Ghassemi Nejad ◽  
Dong-Qiao Peng ◽  
Hye-Ran Kim ◽  
Sang-Ho Kim ◽  
...  
Keyword(s):  
Heat Stress ◽  
Dairy Cows ◽  
Milk Yield ◽  
Milk Fat ◽  
Blood Parameters ◽  
Negative Effects ◽  
Short Term ◽  
Lactating Cows ◽  
Humidity Index ◽  
Holstein Dairy Cows

This study aims to characterize the influence of short-term heat stress (HS; 4 day) in early lactating Holstein dairy cows, in terms of triggering blood metabolomics and parameters, milk yield and composition, and milk microRNA expression. Eight cows (milk yield = 30 ± 1.5 kg/day, parity = 1.09 ± 0.05) were homogeneously housed in environmentally controlled chambers, assigned into two groups with respect to the temperature humidity index (THI) at two distinct levels: approximately ~71 (low-temperature, low-humidity; LTLH) and ~86 (high-temperature, high-humidity; HTHH). Average feed intake (FI) dropped about 10 kg in the HTHH group, compared with the LTLH group (p = 0.001), whereas water intake was only numerically higher (p = 0.183) in the HTHH group than in the LTLH group. Physiological parameters, including rectal temperature (p = 0.001) and heart rate (p = 0.038), were significantly higher in the HTHH group than in the LTLH group. Plasma cortisol and haptoglobin were higher (p < 0.05) in the HTHH group, compared to the LTLH group. Milk yield, milk fat yield, 3.5% fat-corrected milk (FCM), and energy-corrected milk (ECM) were lower (p < 0.05) in the HTHH group than in the LTLH group. Higher relative expression of milk miRNA-216 was observed in the HTHH group (p < 0.05). Valine, isoleucine, methionine, phenylalanine, tyrosine, tryptophan, lactic acid, 3-phenylpropionic acid, 1,5-anhydro-D-sorbitol, myo-inositol, and urea were decreased (p < 0.05). These results suggest that early lactating cows are more vulnerable to short-term (4 day) high THI levels—that is, HTHH conditions—compared with LTLH, considering the enormous negative effects observed in measured blood metabolomics and parameters, milk yield and compositions, and milk miRNA-216 expression.

Effects of dry period length on milk yield and content and metabolic status of high-producing dairy cows under heat stress

2021 ◽  
Vol 53 (2) ◽  
Author(s):  
A. Boustan ◽  
V. Vahedi ◽  
M. Abdi Farab ◽  
H. Karami ◽  
R. Seyedsharifi ◽  
...  
Keyword(s):  
Heat Stress ◽  
Dairy Cows ◽  
Milk Yield ◽  
Period Length ◽  
Metabolic Status ◽  
Dry Period

scholarly journals Effects of Sprinkler Flow Rate on Physiological, Behavioral and Production Responses of Nili Ravi Buffaloes during Subtropical Summer

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 339
Author(s):  
Musa Bah ◽  
Muhammad Afzal Rashid ◽  
Khalid Javed ◽  
Talat Naseer Pasha ◽  
Muhammad Qamer Shahid
Keyword(s):  
Heat Stress ◽  
Milk Yield ◽  
Flow Rate ◽  
Rectal Temperature ◽  
Latin Square ◽  
Flow Rates ◽  
Group Water ◽  
Humidity Index ◽  
Daily Milk Yield ◽  
Daily Milk

Water buffaloes wallow in water to combat heat stress during summer. With the decreasing reservoirs for wallowing, the farmers use sprinklers to cool the buffaloes in Pakistan. These sprinklers use a large quantity of groundwater, which is becoming scarce. The objective of the current study was to determine the effect of different sprinkler flow rates on the physiological, behavioral, and production responses of Nili Ravi buffaloes during summer. Eighteen buffaloes were randomly subjected to three sprinkler flow rate treatments in a double replicated 3 × 3 Latin square design. The flow rates were 0.8, 1.25, and 2.0 L/min. During the study, the average afternoon temperature humidity index was 84.6. The 1.25 and 2.0 L/min groups had significantly lower rectal temperature and respiratory rates than the 0.8 L/min group. Water intake was significantly higher in the 0.8 L/min group. Daily milk yield was higher in the 1.25 and 2.0 L/min groups than in the 0.8 L/min group. These results suggested that the sprinkler flow rates > 0.8 L/min effectively cooled the buffaloes. The sprinkler flow rate of 1.25 L/min appeared to be more efficient, as it used 37.5% less water compared to the 2.0 L/min.

Determination of heat stress zone for daily milk yield using carryover heat effect model in Murrah buffaloes

2021 ◽  
Vol 53 (5) ◽  
Author(s):  
Ramandeep Kaur Dhaliwal ◽  
Puneet Malhotra ◽  
Neeraj Kashyap ◽  
Shakti Kant Dash ◽  
Lakhvir Kaur Dhaliwal ◽  
...  
Keyword(s):  
Heat Stress ◽  
Milk Yield ◽  
Heat Effect ◽  
Murrah Buffaloes ◽  
Effect Model ◽  
Stress Zone ◽  
Daily Milk Yield ◽  
Daily Milk

scholarly journals Effect of heat stress on milk production and its composition of Holstein Friesian crossbred dairy cows

2016 ◽  
Vol 2 (2) ◽  
pp. 190-195 ◽  
Author(s):  
Mahmud Al Reyad ◽  
Md Abid Hasan Sarker ◽  
Md Elias Uddin ◽  
Raihan Habib ◽  
Md Harun Ur Rashid
Keyword(s):  
Heat Stress ◽  
Dairy Cows ◽  
Milk Yield ◽  
Management Practices ◽  
Management Strategies ◽  
Dairy Farm ◽  
Milk Composition ◽  
Mustard Oil ◽  
Holstein Friesian ◽  
Significant Difference

The aim of this research was to observe the effect of heat stress on milk yield and milk compositions of Holstein Friesian crossbred (HF) dairy cows. To fulfill the objectives, a total of 9 Holstein Friesian crossbred cows were selected for this study. Green grasses (German, Para) were supplied adlibitum and concentrate feeds (mixture of wheat bran, rice polish, mustard oil cake, di-calcium phosphate and salt) were supplied at the rate of 2.0 kg/day/cow. Management practices for all the cows were similar following the BAU Dairy farm practices. Data were collected on milk yield (l/h/d), relative humidity (%) and barn temperature (0C). The obtained temperature humidity index (THI) of July, August, September and October were 84.95, 81.99, 81.40 and 79.57, respectively. The highest THI was found in July which indicated higher heat stress during this month. A significant difference (p<0.05) in milk yield of cows was found among different months of July to October. The highest milk yield (6.10±0.50 l/h/d) was found in October among observed months. The compositions of milk such as total solids (TS), solids-not-fat (SNF), fat, protein, lactose, and ash also differed significantly (p<0.01). The highest values (%) of TS, SNF, fat, protein, lactose and ash content of milk were found in October as 12.63, 8.80, 3.83, 3.69, 4.39 and 0.72, respectively and lowest values (%) were in July as 12.20, 8.50, 3.71, 3.50, 4.30 and 0.69, respectively due to the high THI value. From these results, it is concluded that heat stress has strong effect on milk yield and milk composition of HF cows in Bangladesh. Management strategies are needed to minimize heat stress and attain optimal dairy animal performance.Asian J. Med. Biol. Res. June 2016, 2(2): 190-195

scholarly journals Transcriptome Functional Analysis of Mammary Gland of Cows in Heat Stress and Thermoneutral Condition

Animals ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1015 ◽  
Author(s):  
Shuangming Yue ◽  
Zhisheng Wang ◽  
Lizhi Wang ◽  
Quanhui Peng ◽  
Bai Xue
Keyword(s):  
Functional Analysis ◽  
Immune Response ◽  
Heat Stress ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Milk Production ◽  
Milk Yield ◽  
Molecular Mechanisms ◽  
Mammary Glands ◽  
Differentially Expressed

Heat stress (HS) exerts significant effects on the production of dairy animals through impairing health and biological functions. However, the molecular mechanisms related to the effect of HS on dairy cow milk production are still largely unknown. The present study employed an RNA-sequencing approach to explore the molecular mechanisms associated with a decline in milk production by the functional analysis of differentially expressed genes (DEGs) in mammary glands of cows exposed to HS and non-heat-stressed cows. The results of the current study reveal that HS increases the rectal temperature and respiratory rate. Cows under HS result in decreased bodyweight, dry matter intake (DMI), and milk yield. In the current study, a total of 213 genes in experimental cow mammary glands was identified as being differentially expressed by DEGs analysis. Among identified genes, 89 were upregulated, and 124 were downregulated. Gene Ontology functional analysis found that biological processes, such as immune response, chaperone-dependent refolding of protein, and heat shock protein binding activity, were notably affected by HS. The Kyoto Encyclopedia of Genes and Genomes enrichment analysis found that almost all of the top-affected pathways were related to immune response. Under HS, the expression of heat shock protein 90 kDa beta I (HSP90B1) and heat shock 70 kDa protein 1A was upregulated, while the expression of bovine lymphocyte antigen (BoLA) and histocompatibility complex, class II, DRB3 (BoLA-DRB3) was downregulated. We further explored the effects of HS on lactation-related genes and pathways and found that HS significantly downregulated the casein genes. Furthermore, HS increased the expression of phosphorylation of mammalian target of rapamycin, cytosolic arginine sensor for mTORC1 subunit 2 (CASTOR2), and cytosolic arginine sensor for mTORC1 subunit 1 (CASTOR1), but decreased the phosphorylation of Janus kinase-2, a signal transducer and activator of transcription factor-5. Based on the findings of DMI, milk yield, casein gene expression, and the genes and pathways identified by functional annotation analysis, it is concluded that HS adversely affects the immune function of dairy cows. These results will be beneficial to understand the underlying mechanism of reduced milk yield in HS cows.

scholarly journals Genotype–covariate correlation and interaction disentangled by a whole-genome multivariate reaction norm model

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Guiyan Ni ◽  
Julius van der Werf ◽  
Xuan Zhou ◽  
Elina Hyppönen ◽  
Naomi R. Wray ◽  
...  
Keyword(s):  
Reaction Norm ◽  
Whole Genome ◽  
Norm Model
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