Tag‐SNP selection using Bayesian genomewide association study for growth traits in Hereford and Braford cattle

2019 ◽  
Vol 137 (5) ◽  
pp. 449-467
Author(s):  
Gabriel Soares Campos ◽  
Bruna Pena Sollero ◽  
Fernando Antonio Reimann ◽  
Vinicius Silva Junqueira ◽  
Leandro Lunardini Cardoso ◽  
...  
Keyword(s):  
Association Study ◽  
Growth Traits ◽  
Genomewide Association Study ◽  
Tag Snp ◽  
Genomewide Association ◽  
Tag Snp Selection

scholarly journals Genomewide Association Study Confirming the Association of NAT2 with Susceptibility to Antituberculosis Drug-Induced Liver Injury in Thai Patients

2019 ◽  
Vol 63 (8) ◽  
Author(s):  
Supharat Suvichapanich ◽  
Sukanya Wattanapokayakit ◽  
Taisei Mushiroda ◽  
Hideki Yanai ◽  
Charoen Chuchottawon ◽  
...  
Keyword(s):  
Liver Injury ◽  
Association Study ◽  
Chromosome 8 ◽  
Common Side Effect ◽  
Antituberculosis Drug ◽  
Genomewide Association Study ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Tag Snp ◽  
Genomewide Association

ABSTRACT Antituberculosis drug-induced liver injury (ATDILI) is a common side effect leading to tuberculosis (TB) treatment disruption. The mechanism of the disease remains poorly understood. We conducted a genomewide association study (GWAS) to investigate all possible genetic factors of ATDILI in Thai patients. This study was carried out in Thai TB patients, including 79 ATDILI cases and 239 tolerant controls from our network hospitals in Thailand. Nearly 1 million single-nucleotide polymorphisms (SNPs) were genotyped across the whole genome using an Illumina OmniExpress Exome BeadChip array. In the discovery stage, we identified strong association signals on chromosome 8 originating from the N-acetyltransferase (NAT2) region. The A allele of rs1495741, the top SNP in the intergenic region of NAT2 and PSD3 (14 kb from NAT2), was significantly associated with ATDILI (recessive model, odds ratio of 6.01 [95% confidence interval, 3.42 to 10.57]; P = 6.86E−11). This particular SNP was reported as a tag SNP for NAT2 inferred phenotypes. The AA, AG, and GG genotypes represented NAT2 slow acetylators, intermediate acetylators, and fast acetylators, respectively. The tag SNP genotypes demonstrated a concordance rate of 94.98% with NAT2 acetylator phenotypes. This GWAS shows that NAT2 is the most important risk factor for ATDILI in the Thai population.

A genomewide association study identified CYP2J2 as a gene controlling serum vitamin D status in beef cattle1,2

2013 ◽  
Vol 91 (8) ◽  
pp. 3549-3556 ◽  
Author(s):  
E. Casas ◽  
R. J. Leach ◽  
T. A. Reinhardt ◽  
R. M. Thallman ◽  
J. D. Lippolis ◽  
...  
Keyword(s):  
Vitamin D ◽  
Association Study ◽  
Serum Vitamin ◽  
Vitamin D Status ◽  
Genomewide Association Study ◽  
Serum Vitamin D ◽  
Genomewide Association

scholarly journals KARE Genomewide Association Study of Blood Pressure Using Imputed SNPs

2010 ◽  
Vol 8 (3) ◽  
pp. 103-107 ◽  
Author(s):  
Kyung-Won Hong ◽  
Ji-Eun Lim ◽  
Young-Jin Kim ◽  
Nam-H. Cho ◽  
Chol Shin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Association Study ◽  
Genomewide Association Study ◽  
Genomewide Association

scholarly journals Genomewide association study of HLA alloimmunization in previously pregnant blood donors

Transfusion ◽  
2017 ◽  
Vol 58 (2) ◽  
pp. 402-412 ◽  
Author(s):  
Mark Seielstad ◽  
Grier P. Page ◽  
Nathan Gaddis ◽  
Marion Lanteri ◽  
Tzong-Hae Lee ◽  
...  
Keyword(s):  
Association Study ◽  
Blood Donors ◽  
Genomewide Association Study ◽  
Genomewide Association

Dissection of the genetic architecture of rice resistance toXanthomonas oryzaepv.oryzaeusing a genomewide association study

2018 ◽  
Vol 166 (7-8) ◽  
pp. 470-476 ◽  
Author(s):  
Chenggang Li ◽  
Pin Su ◽  
Dan Wang ◽  
Shasha Peng ◽  
Yue Chen ◽  
...  
Keyword(s):  
Association Study ◽  
Genetic Architecture ◽  
Genomewide Association Study ◽  
Genomewide Association

scholarly journals Genomewide Association Study of Movement-Related Adverse Antipsychotic Effects

2010 ◽  
Vol 67 (3) ◽  
pp. 279-282 ◽  
Author(s):  
Karolina Åberg ◽  
Daniel E. Adkins ◽  
József Bukszár ◽  
Bradley T. Webb ◽  
Stanley N. Caroff ◽  
...  
Keyword(s):  
Association Study ◽  
Genomewide Association Study ◽  
Genomewide Association

scholarly journals Efficient Association Study Design Via Power-Optimized Tag SNP Selection

2008 ◽  
Vol 72 (6) ◽  
pp. 834-847 ◽  
Author(s):  
B. Han ◽  
H. M. Kang ◽  
M. S. Seo ◽  
N. Zaitlen ◽  
E. Eskin
Keyword(s):  
Association Study ◽  
Study Design ◽  
Tag Snp ◽  
Tag Snp Selection

scholarly journals Genomewide association study of liver abscess in beef cattle1,2

2016 ◽  
Vol 94 (2) ◽  
pp. 490-499 ◽  
Author(s):  
J. W. Keele ◽  
L. A. Kuehn ◽  
T. G. McDaneld ◽  
R. G. Tait ◽  
S. A. Jones ◽  
...  
Keyword(s):  
Association Study ◽  
Liver Abscess ◽  
Genomewide Association Study ◽  
Genomewide Association
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