scholarly journals Importance of melanin‐based colouration and environment in shaping intracellular glutathione levels in nestling and adult tawny owls Strix aluco

2021 ◽  
Author(s):  
Guillaume Emaresi ◽  
Pierre Bize ◽  
Alexandre Roulin
Keyword(s):  
Strix Aluco ◽  
Intracellular Glutathione

The long-term effect of fitting back-mounted radio tags to juvenile tawny owls Strix aluco

2004 ◽  
Vol 10 (1) ◽  
pp. 161-170 ◽  
Author(s):  
Steve J. Petty ◽  
Bridget M. Appleby ◽  
Christopher F. Coles ◽  
Romain Julliard
Keyword(s):  
Term Effect ◽  
Strix Aluco ◽  
Long Term Effect

Premières données sur le régime alimentaire de la Chouette hulotte (Strix aluco mauritanica) en Algérie

1999 ◽  
Vol 25 (1) ◽  
pp. 111-123
Author(s):  
Watik Hamdine ◽  
Mohamed Boukhemza ◽  
Salaheddine Doumandji ◽  
Françoise Poitevin ◽  
Michel Thevenot
Keyword(s):  
Régime Alimentaire ◽  
Strix Aluco

scholarly journals Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes

2021 ◽  
Author(s):  
Lukas S. Wijaya ◽  
Carina Rau ◽  
Theresa S. Braun ◽  
Serif Marangoz ◽  
Vincent Spegg ◽  
...  
Keyword(s):  
De Novo ◽  
Hepatoma Cell ◽  
Proteasome Inhibitors ◽  
Essential Element ◽  
Hepatoma Cell Line ◽  
Related Factor ◽  
Human Hepatoma Cell ◽  
Intact Cells ◽  
Intracellular Glutathione ◽  
Endogenous Antioxidant

AbstractToxicity is not only a function of damage mechanisms, but is also determined by cellular resilience factors. Glutathione has been reported as essential element to counteract negative influences. The present work hence pursued the question how intracellular glutathione can be elevated transiently to render cells more resistant toward harmful conditions. The antibiotic nitrofurantoin (NFT) was identified to stimulate de novo synthesis of glutathione in the human hepatoma cell line, HepG2, and in primary human hepatocytes. In intact cells, activation of NFT yielded a radical anion, which subsequently initiated nuclear-factor-erythroid 2-related-factor-2 (Nrf2)-dependent induction of glutamate cysteine ligase (GCL). Application of siRNA-based intervention approaches confirmed the involvement of the Nrf2-GCL axis in the observed elevation of intracellular glutathione levels. Quantitative activation of Nrf2 by NFT, and the subsequent rise in glutathione, were similar as observed with the potent experimental Nrf2 activator diethyl maleate. The elevation of glutathione levels, observed even 48 h after withdrawal of NFT, rendered cells resistant to different stressors such as the mitochondrial inhibitor rotenone, the redox cycler paraquat, the proteasome inhibitors MG-132 or bortezomib, or high concentrations of NFT. Repurpose of the antibiotic NFT as activator of Nrf2 could thus be a promising strategy for a transient and targeted activation of the endogenous antioxidant machinery.

scholarly journals Reaction between Graphene Oxide and Intracellular Glutathione Affects Cell Viability and Proliferation

2021 ◽  
Vol 13 (3) ◽  
pp. 3528-3535
Author(s):  
Baojin Ma ◽  
Shi Guo ◽  
Yuta Nishina ◽  
Alberto Bianco
Keyword(s):  
Graphene Oxide ◽  
Cell Viability ◽  
Intracellular Glutathione

A new species and further records of quill mites (Acari: Cheyletoidea: Syringophilidae) parasitic on birds (Aves) in England

Zootaxa ◽  
2009 ◽  
Vol 2133 (1) ◽  
pp. 49-54 ◽  
Author(s):  
BARRY NATTRESS ◽  
MACIEJ SKORACKI
Keyword(s):  
New Species ◽  
Length Ratio ◽  
Additional Species ◽  
Tawny Owl ◽  
Strix Aluco ◽  
Quill Mites ◽  
The Family ◽  
Transverse Branch ◽  
One New Species ◽  
A New Species

Four additional species of quill mites of the family Syringophilidae Lavoipierre have now been recorded in England. This includes one new species, Bubophilus aluconis sp. nov., which parasitizes the tawny owl Strix aluco (Strigiformes: Strigidae). It differs from other species of this genus, B. ascalaphus Philips et Norton, 1978 and B. asiobius Skoracki et Bochkov, 2002 by the number of chambers in transverse branch of the peritremes (2-3), the length ratio of setae vi and ve (1:1.6-2), and the lengths of the stylophore and aggenital setae ag1 (180 and 135-145, respectively).

Reductant substrate for glutathione peroxidase modulates oxidant inhibition of Ca2+ signaling in endothelial cells

1995 ◽  
Vol 268 (1) ◽  
pp. H278-H287 ◽  
Author(s):  
S. J. Elliott ◽  
T. N. Doan ◽  
P. N. Henschke
Keyword(s):  
Endothelial Cells ◽  
Glutathione Peroxidase ◽  
Oxidant Stress ◽  
Glutathione S Transferase ◽  
Glutathione Redox Cycle ◽  
Tert Butyl Hydroperoxide ◽  
Intracellular Glutathione ◽  
Glutamylcysteine Synthetase ◽  
Dependent Signal

Oxidant stress mediated by tert-butyl hydroperoxide (t-BOOH) inhibits agonist-stimulated Ca2+ entry and internal store Ca2+ release in cultured endothelial cells. The role of intracellular glutathione in modulating the effects of oxidant stress on Ca2+ signaling was determined in cells preincubated with buthionine-[S,R]-sulfoximine (BSO), an inhibitor of gamma-glutamylcysteine synthetase, or 1-chloro-2,4-dinitrobenzene (CDNB), a cosubstrate for glutathione-S-transferase. BSO and CDNB decreased endothelial cell glutathione content by 85 and 97%, respectively (control glutathione, 21.5 +/- 2.3 nmol/mg protein). Each agent accelerated the time-dependent effects of t-BOOH on Ca2+ signaling in fura 2-loaded cells and potentiated the inhibition of bradykinin-stimulated 45Ca2+ efflux induced by t-BOOH. These results indicate that decreased availability of reduced glutathione, the primary cosubstrate for glutathione peroxidase, potentiates the effect of hydroperoxide oxidant stress on receptor-operated Ca2+ entry across the plasmalemma and Ca2+ release from internal stores. The present findings suggest that intracellular glutathione availability and/or glutathione redox cycle activity are critically important modulators of oxidant inhibition of Ca(2+)-dependent signal transduction.

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