Identification of spatiotemporal gait parameters and pressure-related characteristics in children with Angelman syndrome: A pilot study

2018 ◽  
Vol 31 (6) ◽  
pp. 1219-1224 ◽  
Author(s):  
Joseph C. Grieco ◽  
Arnaud Gouelle ◽  
Edwin J. Weeber
2017 ◽  
Vol 44 (1) ◽  
pp. 154-162 ◽  
Author(s):  
Bettina Dunkel ◽  
Thilo Pfau ◽  
Andrew Fiske-Jackson ◽  
Kata O. Veres-Nyeki ◽  
Harriet Fairhurst ◽  
...  

Burns ◽  
2020 ◽  
Vol 46 (4) ◽  
pp. 897-905 ◽  
Author(s):  
Melek Merve Erdem ◽  
Gonul Koc ◽  
Kemal Kismet ◽  
Cınar Yasti ◽  
Semra Topuz

2020 ◽  
Author(s):  
Sarah Thompson ◽  
Kaitlin Hays ◽  
Alan Weintraub ◽  
Jessica M Ketchum ◽  
Robert G Kowalski

Abstract Rhythmic auditory stimulation (RAS) has been well researched with stroke survivors and individuals who have Parkinson’s disease, but little research exists on RAS with people who have experienced traumatic brain injury (TBI). This pilot study aimed to (1) assess the feasibility of the study design and (2) explore potential benefits. This single-arm clinical trial included 10 participants who had a 2-week control period between baseline and pretreatment. Participants had RAS daily for a 2-week treatment period and immediately completed post-treatment assessments. Participants then had a 1-week control period and completed follow-up assessment. The starting cadence was evaluated each day of the intervention period due to the variation in daily functioning in this population. All 10 participants were 1–20 years post-TBI with notable deviations in spatial-temporal aspects of gait including decreased velocity, step symmetry, and cadence. All participants had a high risk of falling as defined by achieving less than 22 on the Functional Gait Assessment (FGA). The outcome measures included the 10-m walk test, spatial and temporal gait parameters, FGA, and Physical Activity Enjoyment Scale. There were no adverse events during the study and gait parameters improved. After the intervention, half of the participants achieved a score of more than 22 on the FGA, indicating that they were no longer at high risk of experiencing falls.


Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1697
Author(s):  
Sangmin Park ◽  
Aeyung Kim ◽  
Gunhyuk Park ◽  
Ojin Kwon ◽  
Sangsoo Park ◽  
...  

In this preliminary pilot study, we investigated the specific genes implicated in the therapeutic response to acupuncture in patients with Parkinson’s disease (PD). Transcriptome alterations following acupuncture in blood samples collected during our previous clinical trial were analyzed along with the clinical data of six patients with PD, of which a representative patient was selected for transcriptomic analysis following acupuncture. We also examined the changes in the expression of PD biomarker genes known to be dysregulated in both the brain and blood of patients with PD. We validated these gene expression changes using quantitative real-time polymerase chain reaction (qPCR) in the blood of the remaining five patients with PD who received acupuncture treatment. Following acupuncture treatment, the transcriptomic alterations in the representative patient were similar to those induced by dopaminergic therapy. Among the PD biomarkers, ankyrin repeat domain 22 (ANKRD22), upregulated following dopaminergic therapy, and synapsin 1 (SYN1), a common gene marker for synaptic dysfunction in PD, were upregulated following acupuncture. These alterations correlated with changes in gait parameters in patients with PD. Our data suggest ANKRD22 and SYN1 as potential biomarkers to predict/monitor therapeutic responses to acupuncture in patients with PD, especially in those with gait disturbance. Further research is needed to confirm these findings in a large sample of patients with PD.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Roberta Minino ◽  
Emahnuel Troisi Lopez ◽  
Pierpaolo Sorrentino ◽  
Rosaria Rucco ◽  
Anna Lardone ◽  
...  

AbstractThe efficacy of rhythmic acoustic stimulation (RAS) to improve gait and balance in healthy elderly individuals is controversial. Our aim was to investigate, through 3D gait analysis, the effect of different types of RAS (fixed frequency and based on subject-specific cadence), using conventional gait parameters and the trunk displacement as readouts. Walking at a fixed frequency of 80 bpm, the subjects showed extended duration of gait cycle and increased gait variability while the same individuals, walking at a fixed frequency of 120 bpm, showed reduced trunk sway and gait cycle duration. With regard to the RAS at subject-specific frequencies, walking at 90% of the subject-specific average cadence did not significantly modify the gait parameters, except for the speed, which was reduced. In contrast, walking at 100% and 110% of the mean cadence caused increased stride length and a slight reduction of temporal parameters and trunk sway. In conclusion, this pilot study shows that using RAS at fixed frequencies might be an inappropriate strategy, as it is not adjusted to individual gait characteristics. On the other hand, RAS frequencies equal to or slightly higher than each subject's natural cadence seem to be beneficial for gait and stability.


2012 ◽  
Vol 14 (6) ◽  
pp. 1-10
Author(s):  
Maria R. Grodner ◽  
Krzysztof Dudziński ◽  
Zbigniew Zdrajkowski ◽  
Aneta Molik ◽  
Aleksandra Nosarzewska

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