scholarly journals A review of the antiviral activity of Chitosan, including patented applications, and its potential use against COVID‐19

2021 ◽  
Author(s):  
Nisrein Jaber ◽  
Mayyas Al‐Remawi ◽  
Faisal Al‐Akayleh ◽  
Najah Al‐Muhtaseb ◽  
Ibrahim SI Al‐Adham ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Potential Use

scholarly journals Violacein, A Microbial Antiviral Product: Does Play Key Role as Active Agent Against SARS-CoV-2?

2021 ◽  
Author(s):  
Nelson Duran ◽  
Giselle Z Justo ◽  
Gerson Nakazato ◽  
Wagner J Fávaro
Keyword(s):  
Antiviral Activity ◽  
Protease Inhibitor ◽  
Multidisciplinary Approach ◽  
New Technologies ◽  
Biological Activities ◽  
Active Agent ◽  
Therapeutic Drug ◽  
Microbial Product ◽  
The University ◽  
Potential Use

Violacein, a microbial product was characterized after continuous attempts to feature it, based on degradation and synthesis procedures, at the University of Liverpool (England), from 1958 to 1960 and only at 2001 was chemically synthesized. It is a quite known antimicrobial and antiviral natural product. New attempts to solve the infection caused by, or find the proper therapy for, COVID19, must adopt multidisciplinary approach. The aim of the current study is to address the targets, possible strategies and perspectives of new technologies and therapies on COVID19. It also hypothesizes the potential of using the therapeutic drug called violacein as multifunctional agent to treat patients at different COVID19 contamination stages. Our experience and knowledge about violacein has led us to extrapolate the potential use of this pigment.  Violacein multiple biological activities as also knowledge on its toxicity and antiviral activity enabled suggesting that it could be the new important agent used to treat COVID19.  Violacein is highly likely to act as protease inhibitor, at ACE2 receptor level and as immunotherapeutic drug against Covid19. In term of chemotherapy, it will be discussed the actual antiviral used against COVID19, such as, thalidomide, ivermectin and melatonin, among others.

scholarly journals Marine Sponge is a Promising Natural Source of Anti-SARS-CoV-2 Scaffold

2021 ◽  
Vol 12 ◽  
Author(s):  
Alshaimaa M. Hamoda ◽  
Bahgat Fayed ◽  
Naglaa S. Ashmawy ◽  
Abdel-Nasser A. El-Shorbagi ◽  
Rania Hamdy ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Marine Sponge ◽  
Antiviral Drugs ◽  
Immunomodulatory Activity ◽  
Structural Modifications ◽  
Novel Structure ◽  
Marine Metabolites ◽  
United States Food ◽  
States Food ◽  
Potential Use

The current pandemic caused by SARS-CoV2 and named COVID-19 urgent the need for novel lead antiviral drugs. Recently, United States Food and Drug Administration (FDA) approved the use of remdesivir as anti-SARS-CoV-2. Remdesivir is a natural product-inspired nucleoside analogue with significant broad-spectrum antiviral activity. Nucleosides analogues from marine sponge including spongouridine and spongothymidine have been used as lead for the evolutionary synthesis of various antiviral drugs such as vidarabine and cytarabine. Furthermore, the marine sponge is a rich source of compounds with unique activities. Marine sponge produces classes of compounds that can inhibit the viral cysteine protease (Mpro) such as esculetin and ilimaquinone and human serine protease (TMPRSS2) such as pseudotheonamide C and D and aeruginosin 98B. Additionally, sponge-derived compounds such as dihydrogracilin A and avarol showed immunomodulatory activity that can target the cytokines storm. Here, we reviewed the potential use of sponge-derived compounds as promising therapeutics against SARS-CoV-2. Despite the reported antiviral activity of isolated marine metabolites, structural modifications showed the importance in targeting and efficacy. On that basis, we are proposing a novel structure with bifunctional scaffolds and dual pharmacophores that can be superiorly employed in SARS-CoV-2 infection.

The growth of mica polytypes as studied by conventional and high-resolution TEM

1983 ◽  
Vol 41 ◽  
pp. 174-177
Author(s):  
A. Baronnet ◽  
M. Amouric
Keyword(s):  
Water Pressure ◽  
Point Of View ◽  
Temperature Fields ◽  
Natural Occurrence ◽  
Growth Mechanisms ◽  
Long Period ◽  
High Resolution Tem ◽  
Layer Stacking ◽  
Experimental Works ◽  
Potential Use

The origin of mica polytypes has long been a challenging problem for crystal- lographers, mineralogists and petrologists. From the petrological point of view, interest in this field arose from the potential use of layer stacking data to furnish further informations about equilibrium and/or kinetic conditions prevailing during the crystallization of the widespread mica-bearing rocks. From the compilation of previous experimental works dealing with the occurrence domains of the various mica "polymorphs" (1Mr, 1M, 2M1, 2M2 and 3T) within water-pressure vs temperature fields, it became clear that most of these modifications should be considered as metastable for a fixed mica species. Furthermore, the natural occurrence of long-period (or complex) polytypes could not be accounted for by phase considerations. This highlighted the need of a more detailed kinetic approach of the problem and, in particular, of the role growth mechanisms of basal faces could play in this crystallographic phenomenon.

An atomic-resolution microscope study of Al contracts on GaAs

1986 ◽  
Vol 44 ◽  
pp. 726-727
Author(s):  
Z. Liliental-Weber ◽  
C. Nelson ◽  
R. Ludeke ◽  
R. Gronsky ◽  
J. Washburn
Keyword(s):  
High Speed ◽  
Schottky Contacts ◽  
Detailed Knowledge ◽  
The Past ◽  
Semiconductor Interfaces ◽  
Deposited Metal ◽  
Microwave Applications ◽  
Free Interfaces ◽  
Potential Use

The properties of metal/semiconductor interfaces have received considerable attention over the past few years, and the Al/GaAs system is of special interest because of its potential use in high-speed logic integrated optics, and microwave applications. For such materials a detailed knowledge of the geometric and electronic structure of the interface is fundamental to an understanding of the electrical properties of the contact. It is well known that the properties of Schottky contacts are established within a few atomic layers of the deposited metal. Therefore surface contamination can play a significant role. A method for fabricating contamination-free interfaces is absolutely necessary for reproducible properties, and molecularbeam epitaxy (MBE) offers such advantages for in-situ metal deposition under UHV conditions

The potential use of short chain peptides in parenteral nutrition

1985 ◽  
Vol 4 ◽  
pp. 116-123 ◽  
Author(s):  
P STEHLE ◽  
S ALBERS ◽  
I AMBERGER ◽  
P PFAENDER ◽  
P FURST
Keyword(s):  
Parenteral Nutrition ◽  
Short Chain ◽  
Potential Use

Antiviral activity of EPs® 7630 as assessed in a fibroblast-virus protection assay

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
C Thaele ◽  
A Janecki ◽  
AF Kiderlen ◽  
H Kolodziej
Keyword(s):  
Antiviral Activity ◽  
Protection Assay
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