Medicinal plant extracts protect epithelial cells from infection and DNA damage caused by colibactin‐producing Escherichia coli , and inhibit the growth of bacteria

2020 ◽  
Author(s):  
T. Kaewkod ◽  
R. Tobe ◽  
Y. Tragoolpua ◽  
H. Mihara
Keyword(s):  
Escherichia Coli ◽  
Dna Damage ◽  
Epithelial Cells ◽  
Medicinal Plant ◽  
Plant Extracts ◽  
Medicinal Plant Extracts ◽  
Growth Of Bacteria

scholarly journals Medicinal plant extracts variously modulate susceptibility of Escherichia coli to different antibiotics

2014 ◽  
Vol 169 (4) ◽  
pp. 307-313 ◽  
Author(s):  
Zoya Samoilova ◽  
Galina Smirnova ◽  
Nadezda Muzyka ◽  
Oleg Oktyabrsky
Keyword(s):  
Escherichia Coli ◽  
Medicinal Plant ◽  
Plant Extracts ◽  
Medicinal Plant Extracts

scholarly journals Modulation of Streptomycin Killing Rate against Mature Escherichia Coli Biofilms in the Presence of Medicinal Plant Extracts

2019 ◽  
Vol 4 (5) ◽  
pp. 50-54
Author(s):  
Z. Y. Samoilova ◽  
G. V. Smirnova ◽  
O. N. Oktyabrsky
Keyword(s):  
Escherichia Coli ◽  
Medicinal Plant ◽  
Plant Extracts ◽  
Biofilm Formation ◽  
Antioxidant Properties ◽  
Laminaria Japonica ◽  
Black Tea ◽  
Killing Rate ◽  
Medicinal Plant Extracts ◽  
High Doses

Background. Medicinal plant extracts exhibiting pro- and antioxidant properties may affect antibiotic-induced killing of biofilm-producing bacteria in both synergistic and antagonistic modes. Better understanding of these alternations is required to adjust antibiotic therapy and herbal medicine in order to exclude unwanted losses of antibiotic efficiency.Aim: to study modulation modes of streptomycin killing rate against mature biofilms of Escherichia coli in the presence of different doses of commonly used medicinal plant extracts.Materials and methods. Pharmacodynamic parameter killing rate and mass biofilm formation were determined in the presence of streptomycin and medicinal plant extracts.Results. Synergism was found between 100 mg/ml streptomycin and low doses (0.83 mg of dry herb/ml) of green, black tea, Arctostaphylos uva-ursi, Betula pendula and Laminaria japonica against killing mature biofilms. Alternatively, high doses (6.64 mg of dry herb/ml) of green, black tea and Vaccinium vitis-ideae demonstrated antagonism, decreasing killing rate and enhancing biofilm formation. Presumably, high doses of the extracts were sufficient to enhance biofilm formation blocking penetration of streptomycin through enlarged biofilm matrix and diminishing the killing rate.Conclusions. Widely consumed as soft beverages or for prophylactic purposes green, black tea and V. vitis-ideae could promote strong antagonistic effects with streptomycin. These extracts can stimulate biofilm production, making benefit for commensal microbiota, but have clinical relevance due to a significant reduction in the lethal efficiency of streptomycin in biofilms of pathogenic strains. This highlights the need of careful antibiotic prescription scheme adjustment when choosing appropriate combinations of plant extracts and antibiotics to achieve a synergistic effect.

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