scholarly journals Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats

2019 ◽  
Vol 127 (4) ◽  
pp. 1192-1206 ◽  
Author(s):  
H.A.G. Ducray ◽  
L. Globa ◽  
O. Pustovyy ◽  
E. Morrison ◽  
V. Vodyanoy ◽  
...  
Keyword(s):  
Heat Stress ◽  
Gut Microbiota ◽  
Intestinal Barrier ◽  
Barrier Integrity ◽  
Intestinal Barrier Integrity

scholarly journals Heat Stress Reduces Intestinal Barrier Integrity and Favors Intestinal Glucose Transport in Growing Pigs

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e70215 ◽  
Author(s):  
Sarah C. Pearce ◽  
Venkatesh Mani ◽  
Rebecca L. Boddicker ◽  
Jay S. Johnson ◽  
Thomas E. Weber ◽  
...  
Keyword(s):  
Heat Stress ◽  
Glucose Transport ◽  
Intestinal Barrier ◽  
Growing Pigs ◽  
Barrier Integrity ◽  
Intestinal Barrier Integrity

scholarly journals The Therapeutic Efficacy of Curcumin vs. Metformin in Modulating the Gut Microbiota in NAFLD Rats: A Comparative Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Ruifang Li ◽  
Yurong Yao ◽  
Pengfei Gao ◽  
Shurui Bu
Keyword(s):  
Gut Microbiota ◽  
Therapeutic Efficacy ◽  
Structural Changes ◽  
Intestinal Barrier ◽  
Inflammatory Factors ◽  
Beneficial Bacteria ◽  
Alcoholic Fatty Liver ◽  
Barrier Integrity ◽  
Before And After ◽  
Intestinal Barrier Integrity

Structural disruption of gut microbiota is closely related to the occurrence of non-alcoholic fatty liver disease (NAFLD). Previous research has demonstrated that both curcumin (CUR) and metformin (MET) have a therapeutic effect against NAFLD and play a role in modulating the gut microbiota. However, there is a lack of direct comparison between the two medications in terms of the therapeutic efficacy and the regulatory effect on gut microbiota. In this study, we administered either CUR or MET to rats with high-fat diet (HFD)-induced obesity to observe changes in body parameters, biochemical parameters, liver, and ileum pathology and gut microbiota, and used next generation sequencing and multivariate analysis to evaluate the structural changes of gut microbiota in a NAFLD rat model before and after CUR and MET intervention. It was found that both CUR and MET attenuated hepatic ectopic fat deposition, alleviated inflammatory factors, and improved intestinal barrier integrity in HFD-fed rats. More importantly, CUR and MET reduced the Firmicutes/Bacteroidetes ratio and reverted the composition of the HFD-disrupted gut microbiota. Both CUR and MET treatments effectively modified the gut microbiome, enriched the abundance of beneficial bacteria and reduced opportunistic pathogens in obese rats. The abundance of Butyricicoccus was increased while the abundance of Dorea was decreased in HFD + CUR group. Besides, some beneficial bacteria such as Prevotella were increased in MET-treated animals. Spearman’s correlation analysis showed that Helicobacter, Akkermansia, Desulfovibrio, Romboutsia, Corynebacterium, Lactobacillus, Ruminococcaceae_unclassified, Lachnospiraceae_unclassified, and Clostridiales_unclassified showed significantly positive correlations with TG, TC, LDL-C, GLU, IL-6, IL-1β, and TNF-α, and negative correlations with HDL-C (both p < 0.05). However, Prevotella and Stomatobaculum showed an opposite trend. In summary, CUR and MET showed similar effects in alleviating hepatic steatosis, improving intestinal barrier integrity and modulating gut microbiota in HFD-induced obesity rats, and therefore may prove to be a novel adjunctive therapy for NAFLD.

Electroacupuncture preserves intestinal barrier integrity through modulating the gut microbiota in DSS-induced chronic colitis

Life Sciences ◽  
2020 ◽  
Vol 261 ◽  
pp. 118473
Author(s):  
Lingli Wang ◽  
Jing An ◽  
Shuangning Song ◽  
Minhui Mei ◽  
Wenhua Li ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Intestinal Barrier ◽  
Chronic Colitis ◽  
Barrier Integrity ◽  
Intestinal Barrier Integrity
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