Effects of cytochalasin E on Paracoccidioides brasiliensis

2018 ◽  
Vol 125 (5) ◽  
pp. 1296-1307 ◽  
Author(s):  
G. Mendes ◽  
L.M. Baltazar ◽  
D.G. Souza ◽  
N.P. Sá ◽  
L.H. Rosa ◽  
...  
Keyword(s):  
Paracoccidioides Brasiliensis ◽  
Cytochalasin E

Recognition of Fungal Components by the Host Immune System

2020 ◽  
Vol 21 (3) ◽  
pp. 245-264 ◽  
Author(s):  
Laura C. García-Carnero ◽  
José A. Martínez-Álvarez ◽  
Luis M. Salazar-García ◽  
Nancy E. Lozoya-Pérez ◽  
Sandra E. González-Hernández ◽  
...  
Keyword(s):  
Immune System ◽  
Histoplasma Capsulatum ◽  
Paracoccidioides Brasiliensis ◽  
Sporothrix Schenckii ◽  
Clinical Importance ◽  
Pathogenic Fungi ◽  
Diagnostic Tools ◽  
Future Research ◽  
Host Immune System ◽  
Fungal Antigens

: By being the first point of contact of the fungus with the host, the cell wall plays an important role in the pathogenesis, having many molecules that participate as antigens that are recognized by immune cells, and also that help the fungus to establish infection. The main molecules reported to trigger an immune response are chitin, glucans, oligosaccharides, proteins, melanin, phospholipids, and others, being present in the principal pathogenic fungi with clinical importance worldwide, such as Histoplasma capsulatum, Paracoccidioides brasiliensis, Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Blastomyces dermatitidis, and Sporothrix schenckii. Knowledge and understanding of how the immune system recognizes and responds to fungal antigens are relevant for the future research and development of new diagnostic tools and treatments for the control of mycosis caused by these fungi.

scholarly journals Metabolic Peculiarities of Paracoccidioides brasiliensis Dimorphism as Demonstrated by iTRAQ Labeling Proteomics

2019 ◽  
Vol 10 ◽  
Author(s):  
Danielle Silva Araújo ◽  
Maristela Pereira ◽  
Igor Godinho Portis ◽  
Agenor de Castro Moreira dos Santos Junior ◽  
Wagner Fontes ◽  
...  
Keyword(s):  
Paracoccidioides Brasiliensis ◽  
Itraq Labeling

Brazilian Red Propolis shows antifungal and immunomodulatory activities against Paracoccidioides brasiliensis

2021 ◽  
pp. 114181
Author(s):  
Lauana Aparecida Santos ◽  
Pedro Luiz Rosalen ◽  
Nayara Andrade Dias ◽  
Julianne Caravita Grisolia ◽  
Bruno José Nascimento Gomes ◽  
...  
Keyword(s):  
Paracoccidioides Brasiliensis

scholarly journals Protective Response in Experimental Paracoccidioidomycosis Elicited by Extracellular Vesicles Containing Antigens of Paracoccidioides brasiliensis

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1813
Author(s):  
Ludmila Matos Baltazar ◽  
Gabriela Fior Ribeiro ◽  
Gustavo J. Freitas ◽  
Celso Martins Queiroz-Junior ◽  
Caio Tavares Fagundes ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Treatment Effectiveness ◽  
Ex Vivo ◽  
Paracoccidioides Brasiliensis ◽  
Systemic Disease ◽  
Host Immune System ◽  
Antigen Delivery ◽  
Activated T Lymphocytes ◽  
Cell Mobilization

Paracoccidioidomycosis (PCM) is a systemic disease caused by Paracoccidioides spp. PCM is endemic in Latin America and most cases are registered in Brazil. This mycosis affects mainly the lungs, but can also spread to other tissues and organs, including the liver. Several approaches have been investigated to improve treatment effectiveness and protection against the disease. Extracellular vesicles (EVs) are good antigen delivery vehicles. The present work aims to investigate the use of EVs derived from Paracoccidioides brasiliensis as an immunization tool in a murine model of PCM. For this, male C57BL/6 were immunized with two doses of EVs plus adjuvant and then infected with P. brasiliensis. EV immunization induced IgM and IgG in vivo and cytokine production by splenocytes ex vivo. Further, immunization with EVs had a positive effect on mice infected with P. brasiliensis, as it induced activated T lymphocytes and NKT cell mobilization to the infected lungs, improved production of proinflammatory cytokines and the histopathological profile, and reduced fungal burden. Therefore, the present study shows a new role for P. brasiliensis EVs in the presence of adjuvant as modulators of the host immune system, suggesting their utility as immunizing agents.

scholarly journals Ecology of Paracoccidioides brasiliensis, P. lutzii and related species: infection in armadillos, soil occurrence and mycological aspects

2018 ◽  
Author(s):  
Marluce Francisca Hrycyk ◽  
Hans Garcia Garces ◽  
Sandra de Moraes Gimenes Bosco ◽  
Sílvio Luis de Oliveira ◽  
Sílvio Alencar Marques ◽  
...  
Keyword(s):  
Related Species ◽  
Paracoccidioides Brasiliensis

Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 associated with acquired immunodeficiency syndrome: A case report

2020 ◽  
Author(s):  
Paulo Mendes Peçanha ◽  
Isabela Cruz Bahiense ◽  
Wdson Luis Lima Kruschewsky ◽  
Cláudia Biasutti ◽  
Carlos Urbano Gonçalves Ferreira Júnior ◽  
...  
Keyword(s):  
Case Report ◽  
Acquired Immunodeficiency Syndrome ◽  
Paracoccidioides Brasiliensis ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

scholarly journals Paracoccidioides brasiliensis Isolated from Nine-Banded Armadillos (Dasypus novemcinctus) Reveal Population Structure and Admixture in the Amazon Basin

2021 ◽  
Vol 7 (1) ◽  
pp. 54
Author(s):  
Eduardo Bagagli ◽  
Daniel Ricardo Matute ◽  
Hans Garcia Garces ◽  
Bernardo Guerra Tenório ◽  
Adalberto Garcia Garces ◽  
...  
Keyword(s):  
Population Structure ◽  
Latin America ◽  
Endemic Area ◽  
Amazon Basin ◽  
Paracoccidioides Brasiliensis ◽  
Pathogenic Fungi ◽  
Sensu Stricto ◽  
Species Level ◽  
Dasypus Novemcinctus ◽  
Show Evidence

Paracoccidioidomycosis is an endemic fungal disease to Latin America caused by at least five species-level genotypes of Paracoccidioides, named P. lutzii, P. brasiliensis (S1a and S1b populations), P. americana, P. restrepiensis, and P. venezuelensis. In this manuscript, we report on Paracoccidioides sp. sampling efforts in armadillos from two different areas in Brazil. We sequenced the genomes of seven Paracoccidioides isolates and used phylogenomics and populations genetics for genotyping. We found that P. brasiliensis and P. lutzii are both present in the Amazon region. Additionally, we identified two Paracoccidioides isolates that seem to be the result of admixture between divergent populations within P. brasiliensis sensu stricto. Both of these isolates were recovered from armadillos in a P. lutzii endemic area in Midwestern Brazil. Additionally, two isolates from human patients also show evidence of resulting from admixture. Our results suggest that the populations of P. brasiliensis sensu stricto exchange genes in nature. More generally, they suggest that population structure and admixture within species is an important source of variation for pathogenic fungi.

Identification of Paracoccidioides brasiliensis by gold nanoprobes

2012 ◽  
Author(s):  
Jaciara F. S. Martins ◽  
Maiara L. Castilho ◽  
Maria A. G. Cardoso ◽  
Andrea P. Carreiro ◽  
Airton A. Martin ◽  
...  
Keyword(s):  
Paracoccidioides Brasiliensis
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