scholarly journals Inactivation of Dengue and Yellow Fever viruses by heme, cobalt-protoporphyrin IX and tin-protoporphyrin IX

2016 ◽  
Vol 120 (3) ◽  
pp. 790-804 ◽  
Author(s):  
I. Assunção-Miranda ◽  
C. Cruz-Oliveira ◽  
R.L.S. Neris ◽  
C.M. Figueiredo ◽  
L.P.S. Pereira ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Protoporphyrin Ix ◽  
Cobalt Protoporphyrin ◽  
Tin Protoporphyrin ◽  
Cobalt Protoporphyrin Ix

scholarly journals Cobalt protoporphyrin IX increases endogenous G‐ CSF and mobilizes HSC and granulocytes to the blood

2019 ◽  
Vol 11 (12) ◽  
Author(s):  
Agata Szade ◽  
Krzysztof Szade ◽  
Witold N Nowak ◽  
Karolina Bukowska‐Strakova ◽  
Lucie Muchova ◽  
...  
Keyword(s):  
Protoporphyrin Ix ◽  
Cobalt Protoporphyrin ◽  
Cobalt Protoporphyrin Ix

scholarly journals The Effects of Cobalt Protoporphyrin IX and Tricarbonyldichlororuthenium (II) Dimer Treatments and Its Interaction with Nitric Oxide in the Locus Coeruleus of Mice with Peripheral Inflammation

2019 ◽  
Vol 20 (9) ◽  
pp. 2211 ◽  
Author(s):  
Patricia Moreno ◽  
Rafael Alves Cazuza ◽  
Joyce Mendes-Gomes ◽  
Andrés Felipe Díaz ◽  
Sara Polo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Locus Coeruleus ◽  
Inflammatory Pain ◽  
Protoporphyrin Ix ◽  
Heme Oxygenase 1 ◽  
Peripheral Inflammation ◽  
Inflammatory Reactions ◽  
Cobalt Protoporphyrin ◽  
Cobalt Protoporphyrin Ix

Heme oxygenase 1 (HO-1) and carbon monoxide were shown to normalize oxidative stress and inflammatory reactions induced by neuropathic pain in the central nervous system, but their effects in the locus coeruleus (LC) of animals with peripheral inflammation and their interaction with nitric oxide are unknown. In wild-type (WT) and knockout mice for neuronal (NOS1-KO) or inducible (NOS2-KO) nitric oxide synthases with inflammatory pain induced by complete Freund’s adjuvant (CFA), we assessed: (1) antinociceptive actions of cobalt protoporphyrin IX (CoPP), an HO-1 inducer; (2) effects of CoPP and tricarbonyldichlororuthenium(II) dimer (CORM-2), a carbon monoxide-liberating compound, on the expression of HO-1, NOS1, NOS2, CD11b/c, GFAP, and mitogen-activated protein kinases (MAPK) in the LC. CoPP reduced inflammatory pain in different time-dependent manners in WT and KO mice. Peripheral inflammation activated astroglia in the LC of all genotypes and increased the levels of NOS1 and phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK 1/2) in WT mice. CoPP and CORM-2 enhanced HO-1 and inhibited astroglial activation in all genotypes. Both treatments blocked NOS1 overexpression, and CoPP normalized ERK 1/2 activation. This study reveals an interaction between HO-1 and NOS1/NOS2 during peripheral inflammation and shows that CoPP and CORM-2 improved HO-1 expression and modulated the inflammatory and/or plasticity changes caused by peripheral inflammation in the LC.

scholarly journals Formation of bile pigments by coupled oxidation of cobalt-substituted haemoglobin and myoglobin

1984 ◽  
Vol 223 (1) ◽  
pp. 205-209 ◽  
Author(s):  
D I Vernon ◽  
S B Brown
Keyword(s):  
Protoporphyrin Ix ◽  
Bile Pigments ◽  
Cobalt Protoporphyrin ◽  
Cobalt Protoporphyrin Ix

Treatment of cobalt-substituted haemoglobin and myoglobin with ascorbate and molecular O2 (coupled oxidation) resulted in biliverdin formation from the cobalt(II) derivatives but not from the cobalt(III) derivatives. This was apparently due to the inability of ascorbate to reduce cobalt(III) haemoproteins. Isomer analysis of the biliverdins produced from coupled oxidation of cobalt(II) oxyhaemoglobin suggested that the orientation of the cobalt protoporphyrin IX in the haem pocket differed slightly from that of the haem in native haemoglobin.

Protein secondary-shell interactions enhance the photoinduced hydrogen production of cobalt protoporphyrin IX

2014 ◽  
Vol 50 (100) ◽  
pp. 15852-15855 ◽  
Author(s):  
Dayn Joseph Sommer ◽  
Michael David Vaughn ◽  
Giovanna Ghirlanda
Keyword(s):  
Hydrogen Production ◽  
Protoporphyrin Ix ◽  
Molecular Catalyst ◽  
Cobalt Protoporphyrin ◽  
Photoinduced Hydrogen Production ◽  
Cobalt Protoporphyrin Ix

An efficient molecular catalyst for hydrogen production is generated by incorporating Co-protoporphyrin IX into myoglobin. The activity is modulated by engineered mutations.

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