scholarly journals Relation between virulence of Vibrio anguillarum strains and response to the host factors mucin, bile salts and cholesterol

2015 ◽  
Vol 119 (1) ◽  
pp. 25-32 ◽  
Author(s):  
X. Li ◽  
T. Defoirdt ◽  
P. Bossier
Keyword(s):  
Bile Salts ◽  
Vibrio Anguillarum ◽  
Host Factors

scholarly journals Bile Facilitates Human Norovirus Interactions with Diverse Histoblood Group Antigens, Compensating for Capsid Microvariation Observed in 2016–2017 GII.2 Strains

Viruses ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 989
Author(s):  
Michael L. Mallory ◽  
Lisa C. Lindesmith ◽  
Paul D. Brewer-Jensen ◽  
Rachel L. Graham ◽  
Ralph S. Baric
Keyword(s):  
Mucosal Immunity ◽  
Bile Salts ◽  
Rapid Evolution ◽  
Blood Group Antigen ◽  
Host Factors ◽  
Viral Capsid ◽  
Human Populations ◽  
Human Norovirus ◽  
Sudden Rise ◽  
Limited Sequence

Human norovirus (HuNoV) is the leading cause of global infectious acute gastroenteritis, causing ~20% of reported diarrheal episodes. Typically, GII.4 strains cause 50–70% of yearly outbreaks, and pandemic waves of disease approximately every 2–7 years due to rapid evolution. Importantly, GII.4 dominance is occasionally challenged by the sudden emergence of other GII strains, most recently by GII.2 strains which peaked in 2016–2017, dramatically increasing from 1% to 20% of total HuNoV outbreaks. To determine if viral capsid evolution may account for the sudden rise in GII.2 outbreaks, Virus Like Particles (VLPs) of two 2016–2017 GII.2 strains were compared by antigenic and histo blood group antigen (HBGA) binding profiles to the prototypic 1976 GII.2 Snow Mountain Virus (SMV) strain. Despite >50 years of GII.2 strain persistence in human populations, limited sequence diversity and antigenic differences were identified between strains. However, capsid microvariation did affect HBGA binding patterns, with contemporary strains demonstrating decreased avidity for type A saliva. Furthermore, bile salts increased GII.2 VLP avidity for HBGAs, but did not alter antigenicity. These data indicate that large changes in antigenicity or receptor binding are unlikely to explain GII.2 emergence, in contrast to the pandemic GII.4 strains, and indicate that host factors such as waning or remodeling of serum or mucosal immunity likely contributed to the surge in GII.2 prevalence.

scholarly journals Iron Shortage and Bile Salts Play a Major Role in the Expression of ompK Gene in Vibrio anguillarum

2014 ◽  
Vol 63 (1) ◽  
pp. 27-31 ◽  
Author(s):  
MOHAMMED A. HAMOD ◽  
PATIT P. BHOWMICK ◽  
YASSAMIN N. SHUKUR ◽  
IDDYA KARUNASAGAR ◽  
INDRANI KARUNASAGAR
Keyword(s):  
Vibrio Parahaemolyticus ◽  
Bile Salts ◽  
Iron Acquisition ◽  
Vibrio Anguillarum ◽  
Chelating Agent ◽  
Culture Conditions ◽  
Iron Limitation ◽  
Broad Host Range ◽  
Blot Technique ◽  
Bile Resistance

The outer membrane protein K, OmpK first identified in Vibrio parahaemolyticus has been shown to be a receptor for a broad host range vibriophage KVP40 infecting members of the Vibrionaceae. In the study, the effect of culture conditions on the expression of ompK in V. anguillarum was studied using real-time PCR. The expression increased significantly in the presence of bile salts and iron chelating agent 2, 2' bipyridine, suggesting a role for this protein in bile resistance and also in iron acquisition by V. anguillarum. OmpK induction by iron limitation and the presence of bile salts was reconfirmed by western blot technique after growing the cells in trypticase soy broth supplemented with bile salts, blood and 2, 2' bipyridine. We surmise that the expression of OmpK protein of V. anguillarum is bile salt and iron chelating agent-dependent.

The Biological Importance of Bile Salts

1979 ◽  
Vol 7 (6) ◽  
pp. 1323-1323
Author(s):  
H. DANIELSSON
Keyword(s):  
Bile Salts ◽  
Biological Importance

Functional intravital two-photon based imaging of bile salts transport in cholestasis: mechanisms and consequences of bile infarcts formation

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
A Ghallab ◽  
U Hofmann ◽  
N Vartak ◽  
R Hassan ◽  
P Godoy ◽  
...  
Keyword(s):  
Bile Salts ◽  
Two Photon

Host factors in bacteremic CAP

Pneumologie ◽  
2004 ◽  
Vol 58 (S 1) ◽  
Author(s):  
R Erzen ◽  
E Music ◽  
V Tomic
Keyword(s):  
Host Factors

Coadministration of citric acid allows oxytetracycline dose reduction in yellowtail Seriola quinqueradiata infected with Vibrio anguillarum

2020 ◽  
Vol 140 ◽  
pp. 25-29
Author(s):  
K Akiyama ◽  
N Hirazawa ◽  
A Hatanaka
Keyword(s):  
Body Weight ◽  
Citric Acid ◽  
Effective Treatment ◽  
Dose Reduction ◽  
Vibrio Anguillarum ◽  
Enhancing Effect ◽  
Bacterial Diseases ◽  
Seriola Quinqueradiata ◽  
Poor Efficacy

Oxytetracycline (OTC) has been commonly used as an effective antibiotic against various fish bacterial diseases, including vibriosis. In this study, the absorption-enhancing effect of citric acid on oral OTC pharmacokinetics and treatment of artificial Vibrio anguillarum infection was evaluated in juvenile yellowtail Seriola quinqueradiata followed by serum OTC concentration analysis. When 25 mg kg-1 body weight (BW) OTC was administered in combination with 1250 mg kg-1 BW citric acid, the serum OTC concentration reached almost the same concentration as that of the group treated with 50 mg kg-1 BW OTC. This coadministration successfully suppressed mortality due to vibriosis similar to the group treated with 50 mg kg-1 BW OTC. Conversely, poor efficacy was observed when only 25 mg kg-1 BW OTC was administered. These results suggest that coadministration of citric acid can be beneficial in reducing the dose of OTC needed for effective treatment, and thus contributes to the goal of reduced use of this antibiotic in aquaculture.

Nomenclature Abstract for Vibrio anguillarum Bergeman 1909 (Approved Lists 1980).

2003 ◽  
Author(s):  
Charles Thomas Parker ◽  
Dorothea Taylor ◽  
George M Garrity
Keyword(s):  
Vibrio Anguillarum
Sign in / Sign up

Export Citation Format

Share Document