scholarly journals In vitro evaluation of the acquisition of resistance, antifungal activity and synergism of Brazilian red propolis with antifungal drugs on Candida spp.

2015 ◽  
Vol 118 (4) ◽  
pp. 839-850 ◽  
Author(s):  
B. Pippi ◽  
A.J.D. Lana ◽  
R.C. Moraes ◽  
C.M. Güez ◽  
M. Machado ◽  
...  
2008 ◽  
pp. 1-6 ◽  
Author(s):  
Ayse Nedret Koc ◽  
Sibel Silici ◽  
Baris Derya Ercal ◽  
Filiz Kasap ◽  
Hatice Tuna Hormet-Oz ◽  
...  

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 998
Author(s):  
Virgínia Barreto Lordello ◽  
Andréia Bagliotti Meneguin ◽  
Sarah Raquel de Annunzio ◽  
Maria Pía Taranto ◽  
Marlus Chorilli ◽  
...  

Background: Probiotic bacteria have been emerging as a trustworthy choice for the prevention and treatment of Candida spp. infections. This study aimed to develop and characterize an orodispersible film (ODF) for delivering the potentially probiotic Enterococcus faecium CRL 183 into the oral cavity, evaluating its in vitro antifungal activity against Candida albicans. Methods and Results: The ODF was composed by carboxymethylcellulose, gelatin, and potato starch, and its physical, chemical, and mechanical properties were studied. The probiotic resistance and viability during processing and storage were evaluated as well as its in vitro antifungal activity against C. albicans. The ODFs were thin, resistant, and flexible, with neutral pH and microbiologically safe. The probiotic resisted the ODF obtaining process, demonstrating high viability (>9 log10 CFU·g−1), up to 90 days of storage at room temperature. The Probiotic Film promoted 68.9% of reduction in fungal early biofilm and 91.2% in its mature biofilm compared to the group stimulated with the control film. Those results were confirmed through SEM images. Conclusion: The probiotic ODF developed is a promising strategy to prevent oral candidiasis, since it permits the local probiotic delivery, which in turn was able to reduce C. albicans biofilm formation.


2015 ◽  
Vol 9 (36) ◽  
pp. 2006-2012 ◽  
Author(s):  
Eug ecirc nia Nunes Luanne ◽  
Paula Porto Viana Anna ◽  
Raianny Vieira da Rocha Wilma ◽  
Dorneles de Sena Cunha Vannuty ◽  
Mayer Ramalho Cat atilde o Ra iuml ssa ◽  
...  

2018 ◽  
Vol 5 (3) ◽  
pp. 171814 ◽  
Author(s):  
Chang Shu ◽  
Tengfei Li ◽  
Wen Yang ◽  
Duo Li ◽  
Shunli Ji ◽  
...  

The present work is focused on the design and development of novel amphotericin B (AmB)-conjugated biocompatible and biodegradable polypeptide hydrogels to improve the antifungal activity. Using three kinds of promoting self-assembly groups (2-naphthalene acetic acid (Nap), naproxen (Npx) and dexamethasone (Dex)) and polypeptide sequence (Phe-Phe-Asp-Lys-Tyr, FFDKY), we successfully synthesized the Nap-FFDK(AmB)Y gels, Npx-FFDK(AmB)Y gels and Dex-FFDK(AmB)Y gels. The AmB-conjugated hydrogelators are highly soluble in different aqueous solutions. The cryo-transmission electron microscopy and scanning electron microscopy micrographs of hydrogels afford nanofibres with a width of 20–50 nm. Powder X-ray diffraction analyses demonstrate that the crystalline structures of the AmB and Dex are changed into amorphous structures after the formation of hydrogels. Circular dichroism spectra of the solution of blank carriers and the corresponding drug deliveries further help elucidate the molecular arrangement in gel phase, indicating the existence of turn features. The in vitro drug releases suggest that the AmB-conjugated hydrogels are suitable as drug-controlled release vehicles for hydrophobic drugs. The antifungal effect of AmB-conjugated hydrogels significantly exhibits the antifungal activity against Candida albicans . The results of the present study indicated that the AmB-conjugated hydrogels are suitable carriers for poorly water soluble drugs and for enhancement of therapeutic efficacy of antifungal drugs.


2005 ◽  
Vol 15 (4) ◽  
pp. 247-249 ◽  
Author(s):  
C.P. Abirami ◽  
P.V. Venugopal

2013 ◽  
Vol 7 (20) ◽  
pp. 2245-2250 ◽  
Author(s):  
Brum Cleff Marlete ◽  
Madrid Isabel ◽  
Raquel Meinerz Ana ◽  
Carlos Arauacute jo Meireles Maacute rio ◽  
Roberto Braga de Mello Joatilde o ◽  
...  

2008 ◽  
Vol 44 (4) ◽  
pp. 310-315 ◽  
Author(s):  
P.O. Santos ◽  
I.S. Santos ◽  
V.M. Gomes ◽  
O.L.T. Machado ◽  
K.V.S. Fernandes ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document